Immunotherapy emerges as promising approach for treating cancer. Encouraging findings have validated the efficacy of immunotherapy medications in addressing tumors, resulting in prolonged survival rates and notable reductions in toxicity compared to conventional chemotherapy methods. However, the pool of eligible patients for immunotherapy remains relatively small, indicating a lack of comprehensive understanding regarding the physiological mechanisms responsible for favorable treatment response in certain individuals while others experience limited benefits. To tackle this issue, the authors present an innovative strategy that harnesses a non-linear cellular architecture in conjunction with a deep downstream classifier. This approach aims to carefully select and enhance 2D features extracted from chest-abdomen CT images, thereby improving the prediction of treatment outcomes. The proposed pipeline has been meticulously designed to seamlessly integrate with an advanced embedded Point of Care system. In this context, the authors present a compelling case study focused on Metastatic Urothelial Carcinoma (mUC), a particularly aggressive form of cancer. Performance evaluation of the proposed approach underscores its effectiveness, with an impressive overall accuracy of approximately 93%

When faced with a large number of product reviews, it is not clear that a human can remember all of them and weight opinions representatively to write a good reference summary. We propose an automatic metric to test the prevalence of the opinions that a summary expresses, based on counting the number of reviews that are consistent with each statement in the summary, while discrediting trivial or redundant statements. To formulate this opinion prevalence metric, we consider several existing methods to score the factual consistency of a summary statement with respect to each individual source review. On a corpus of Amazon product reviews, we gather multiple human judgments of the opinion consistency, to determine which automatic metric best expresses consistency in product reviews. Using the resulting opinion prevalence metric, we show that a human authored summary has only slightly better opinion prevalence than randomly selected extracts from the source reviews, and previous extractive and abstractive unsupervised opinion summarization methods perform worse than humans. We demonstrate room for improvement with a greedy construction of extractive summaries with twice the opinion prevalence achieved by humans. Finally, we show that preprocessing source reviews by simplification can raise the opinion prevalence achieved by existing abstractive opinion summarization systems to the level of human performance.

Transformer-based pretrained language models (PLMs) have achieved great success in modern NLP. An important advantage of PLMs is good out-of-distribution (OOD) robustness. Recently, diffusion models have attracted a lot of work to apply diffusion to PLMs. It remains under-explored how diffusion influences PLMs on OOD data. The core of diffusion models is a forward diffusion process which gradually applies Gaussian noise to inputs, and a reverse denoising process which removes noise. The noised input reconstruction is a fundamental ability of diffusion models. We directly analyze OOD robustness by measuring the reconstruction loss, including testing the abilities to reconstruct OOD data, and to detect OOD samples. Experiments are conducted by analyzing different training parameters and data statistical features on eight datasets. It shows that finetuning PLMs with diffusion degrades the reconstruction ability on OOD data. The comparison also shows that diffusion models can effectively detect OOD samples, achieving state-of-the-art performance in most of the datasets with an absolute accuracy improvement up to 18%. These results indicate that diffusion reduces OOD robustness of PLMs.

We consider the vulnerability of fairness-constrained learning to small amounts of malicious noise in the training data. Konstantinov and Lampert (2021) initiated the study of this question and presented negative results showing there exist data distributions where for several fairness constraints, any proper learner will exhibit high vulnerability when group sizes are imbalanced. Here, we present a more optimistic view, showing that if we allow randomized classifiers, then the landscape is much more nuanced. For example, for Demographic Parity we show we can incur only a $\Theta(\alpha)$ loss in accuracy, where $\alpha$ is the malicious noise rate, matching the best possible even without fairness constraints. For Equal Opportunity, we show we can incur an $O(\sqrt{\alpha})$ loss, and give a matching $\Omega(\sqrt{\alpha})$lower bound. In contrast, Konstantinov and Lampert (2021) showed for proper learners the loss in accuracy for both notions is $\Omega(1)$. The key technical novelty of our work is how randomization can bypass simple "tricks" an adversary can use to amplify his power. We also consider additional fairness notions including Equalized Odds and Calibration. For these fairness notions, the excess accuracy clusters into three natural regimes $O(\alpha)$,$O(\sqrt{\alpha})$ and $O(1)$. These results provide a more fine-grained view of the sensitivity of fairness-constrained learning to adversarial noise in training data.

Generative image modeling enables a wide range of applications but raises ethical concerns about responsible deployment. This paper introduces an active strategy combining image watermarking and Latent Diffusion Models. The goal is for all generated images to conceal an invisible watermark allowing for future detection and/or identification. The method quickly fine-tunes the latent decoder of the image generator, conditioned on a binary signature. A pre-trained watermark extractor recovers the hidden signature from any generated image and a statistical test then determines whether it comes from the generative model. We evaluate the invisibility and robustness of the watermarks on a variety of generation tasks, showing that Stable Signature works even after the images are modified. For instance, it detects the origin of an image generated from a text prompt, then cropped to keep $10\%$ of the content, with $90$+$\%$ accuracy at a false positive rate below 10$^{-6}$.

One of the main tasks of actuaries and data scientists is to build good predictive models for certain phenomena such as the claim size or the number of claims in insurance. These models ideally exploit given feature information to enhance the accuracy of prediction. This user guide revisits and clarifies statistical techniques to assess the calibration or adequacy of a model on the one hand, and to compare and rank different models on the other hand. In doing so, it emphasises the importance of specifying the prediction target functional at hand a priori (e.g. the mean or a quantile) and of choosing the scoring function in model comparison in line with this target functional. Guidance for the practical choice of the scoring function is provided. Striving to bridge the gap between science and daily practice in application, it focuses mainly on the pedagogical presentation of existing results and of best practice. The results are accompanied and illustrated by two real data case studies on workers' compensation and customer churn.

This paper study provides a novel contribution to the field of signal processing and DL for ECG signal analysis by introducing a new feature representation method for ECG signals. The proposed method is based on transforming time frequency 1D vectors into 2D images using Gramian Angular Field transform. Moving on, the classification of the transformed ECG signals is performed using Convolutional Neural Networks (CNN). The obtained results show a classification accuracy of 97.47% and 98.65% for anomaly detection. Accordingly, in addition to improving the classification performance compared to the state-of-the-art, the feature representation helps identify and visualize temporal patterns in the ECG signal, such as changes in heart rate, rhythm, and morphology, which may not be apparent in the original signal. This has significant implications in the diagnosis and treatment of cardiovascular diseases and detection of anomalies.

Social coding platforms have revolutionized collaboration in software development, leading to using software bots for streamlining operations. However, The presence of open-source software (OSS) bots gives rise to problems including impersonation, spamming, bias, and security risks. Identifying bot accounts and behavior is a challenging task in the OSS project. This research aims to investigate bots' behavior in open-source software projects and identify bot accounts with maximum possible accuracy. Our team gathered a dataset of 19,779 accounts that meet standardized criteria to enable future research on bots in open-source projects. We follow a rigorous workflow to ensure that the data we collect is accurate, generalizable, scalable, and up-to-date. We've identified four types of bot accounts in open-source software projects by analyzing their behavior across 17 features in 5 dimensions. Our team created BotHawk, a highly effective model for detecting bots in open-source software projects. It outperforms other models, achieving an AUC of 0.947 and an F1-score of 0.89. BotHawk can detect a wider variety of bots, including CI/CD and scanning bots. Furthermore, we find that the number of followers, number of repositories, and tags contain the most relevant features to identify the account type.

Supervised classification algorithms are used to solve a growing number of real-life problems around the globe. Their performance is strictly connected with the quality of labels used in training. Unfortunately, acquiring good-quality annotations for many tasks is infeasible or too expensive to be done in practice. To tackle this challenge, active learning algorithms are commonly employed to select only the most relevant data for labeling. However, this is possible only when the quality and quantity of labels acquired from experts are sufficient. Unfortunately, in many applications, a trade-off between annotating individual samples by multiple annotators to increase label quality vs. annotating new samples to increase the total number of labeled instances is necessary. In this paper, we address the issue of faulty data annotations in the context of active learning. In particular, we propose two novel annotation unification algorithms that utilize unlabeled parts of the sample space. The proposed methods require little to no intersection between samples annotated by different experts. Our experiments on four public datasets indicate the robustness and superiority of the proposed methods in both, the estimation of the annotator's reliability, and the assignment of actual labels, against the state-of-the-art algorithms and the simple majority voting.

Machine learning methods to aid defence systems in detecting malicious activity typically rely on labelled data. In some domains, such labelled data is unavailable or incomplete. In practice this can lead to low detection rates and high false positive rates, which characterise for example anti-money laundering systems. In fact, it is estimated that 1.7--4 trillion euros are laundered annually and go undetected. We propose The GANfather, a method to generate samples with properties of malicious activity, without label requirements. We propose to reward the generation of malicious samples by introducing an extra objective to the typical Generative Adversarial Networks (GANs) loss. Ultimately, our goal is to enhance the detection of illicit activity using the discriminator network as a novel and robust defence system. Optionally, we may encourage the generator to bypass pre-existing detection systems. This setup then reveals defensive weaknesses for the discriminator to correct. We evaluate our method in two real-world use cases, money laundering and recommendation systems. In the former, our method moves cumulative amounts close to 350 thousand dollars through a network of accounts without being detected by an existing system. In the latter, we recommend the target item to a broad user base with as few as 30 synthetic attackers. In both cases, we train a new defence system to capture the synthetic attacks.