Modeling the dynamics from sparsely time-resolved snapshot data is crucial for understanding complex cellular processes and behavior.

Traditional Chinese Medicine (TCM), as an effective alternative medicine, has been receiving increasing attention. In recent years, the rapid development of large language models (LLMs) tailored for TCM has highlighted the urgent need for an objective and comprehensive evaluation framework to assess their performance on real-world tasks. However, existing evaluation datasets are limited in scope and primarily text-based, lacking a unified and standardized multimodal questionanswering (QA) benchmark. To address this issue, we introduced TCM-Ladder, the first comprehensive multimodal QA dataset specifically designed for evaluating large TCM language models. The dataset covers multiple core disciplines of TCM, including fundamental theory, diagnostics, herbal formulas, internal medicine, surgery, pharmacognosy, and pediatrics.

Large Language Models have demonstrated impressive fluency across diverse tasks, yet their tendency to produce toxic content remains a critical challenge for AI safety and public trust. Existing toxicity mitigation approaches primarily manipulate individual neuron activations, but these methods suffer from instability, context dependence, and often compromise the model's core language abilities. To address these shortcomings, we investigate three key questions: the stability of neuron-level toxicity indicators, the advantages of structural (layer-wise) representations, and the interpretability of mechanisms driving toxic generation. Through extensive experiments on Jigsawand ToxiCNdatasets, we show that aggregated layer-wise features provide more robust signals than single neurons. Moreover, we observe conceptual limitations in prior works that conflate toxicity detection experts and generation experts within neuron-based interventions. To mitigate this, we propose a novel principled intervention technique, EigenShift, based on eigen-decomposition of the language model's final output layer. This method selectively targets generation-aligned components, enabling precise toxicity suppression without impairing linguistic competence. Our method requires no additional training or fine-tuning, incurs minimal computational cost, and is grounded in rigorous theoretical analysis.

Large Reasoning Models (LRMs) have significantly enhanced their capabilities in complex problem-solving by introducing a thinking draft that enables multipath Chain-of-Thought explorations before producing final answers. Ensuring the faithfulness of these intermediate reasoning processes is crucial for reliable monitoring, interpretation, and effective control. In this paper, we propose a systematic counterfactual intervention framework to rigorously evaluate thinking draft faithfulness. Our approach focuses on two complementary dimensions: (1) IntraDraft Faithfulness, which assesses whether individual reasoning steps causally influence subsequent steps and the final draft conclusion through counterfactual step insertions; and (2) Draft-to-Answer Faithfulness, which evaluates whether final answers are logically consistent with and dependent on the thinking draft, by perturbing the draft's concluding logic. We conduct extensive experiments across six state-of-the-art LRMs. Our findings show that current LRMs demonstrate selective faithfulness to intermediate reasoning steps and frequently fail to faithfully align with the draft conclusions. These results underscore the need for more faithful and interpretable reasoning in advanced LRMs.

This position paper challenges the "scaling fundamentalism" dominating AI research, where unbounded growth in model size and computation has led to unsustainable environmental impacts and widening resource inequality. We argue that LLM development should be fundamentally reoriented toward capability-perresource rather than capability alone. We present a theoretical framework demonstrating that resource-allocation decisions guided by gradient influence patterns can dramatically improve efficiency throughout the AI lifecycle. Our analysis shows that in transformer-based models, where a small fraction of parameters exert outsized influence (following heavy-tailed distributions), three critical insights emerge: (1) updating only high-influence parameters strictly outperforms full-parameter tuning on a performance-per-resource basis; (2) simple gradient norms provide computationally efficient proxies for identifying these high-influence components; and (3) coordinated parameter and data selection yields multiplicative efficiency gains, potentially reducing resource requirements by orders of magnitude. Building on these theoretical foundations, we propose a two-stage paradigm--marginalreturn pretraining for foundation developers and influence-guided adaptation for downstream users--bridged by gradient blueprints, metadata describing which parameters matter most for various tasks. This capability-per-resource perspective transforms what were once considered pragmatic hardware workarounds into theoretically optimal strategies, democratizing access to cutting-edge AI capabilities while significantly reducing environmental impact. By embedding resource consciousness into how we develop, adapt, and evaluate models, we can reshape AI progress toward a more sustainable and equitable future.

State Space models (SSMs) like PointMamba provide efficient feature extraction for point cloud self-supervised learning with linear complexity, surpassing Transformers in computational efficiency. However, existing PointMamba-based methods rely on complex token ordering and random masking, disrupting spatial continuity and local semantic correlations. We propose ZigzagPointMamba to address these challenges. The key to our approach is a simple zigzag scan path that globally sequences point cloud tokens, enhancing spatial continuity by preserving the proximity of spatially adjacent point tokens.

Evaluating the step-by-step reliability of large language model (LLM) reasoning, such as Chain-of-Thought, remains challenging due to the difficulty and cost of obtaining high-quality step-level supervision. In this paper, we introduce SelfPlay Critic (SPC), a novel approach where a critic model evolves its ability to assess reasoning steps through adversarial self-play games, eliminating the need for manual step-level annotation. SPC involves fine-tuning two copies of a base model to play two roles, namely a "sneaky generator" that deliberately produces erroneous steps designed to be difficult to detect, and a "critic" that analyzes the correctness of reasoning steps. These two models engage in an adversarial game in which the generator aims to fool the critic, while the critic model seeks to identify the generator's errors. Using reinforcement learning based on the game outcomes, the models iteratively improve; the winner of each confrontation receives a positive reward and the loser receives a negative reward, driving continuous self-evolution. Experiments on three reasoning process benchmarks (ProcessBench, PRM800K, DeltaBench) demonstrate that our SPC progressively enhances its error detection capabilities (e.g., accuracy increases from 70.8% to 77.7% on ProcessBench) and surpasses strong baselines, including distilled R1 model. Furthermore, SPC can guide the test-time search of diverse LLMs and significantly improve their mathematical reasoning performance on MATH500 and AIME2024, surpassing those guided by state-of-the-art process reward models.

Instruction-based image editing enables precise modifications via natural language prompts, but existing methods face a precision-efficiency tradeoff: fine-tuning demands massive datasets (>10M) and computational resources, while trainingfree approaches suffer from weak instruction comprehension.

A.1 Behavioral Task A male nonhuman primate (NHP, Macaca mulatta), Monkey N (age 7 at the beginning of the dataset, age 11 at the end), was trained to perform a trial-based, two degree-of-freedom (DOF) dexterous finger movement task, shown in Figure 1. During all sessions, Monkey N sat in a primate chair (Crist Instruments, Hagerstown, MA) in a shielded chamber, with his arms fixed at his sides and flexed 90 degrees at the elbow, resting on a table. The left hand was positioned securely in a manipulandum, which used bend sensors (FS-L-0073-103-ST, Spectra Symbol, Salt Lake City, UT) to measure the flexion of two finger groups, index (IDX) and middle-ring-small (MRS). At the beginning of each experimental session (and as needed throughout a session), these flexion sensors were calibrated such that a reading of 1 indicated full flexion of a finger group and a reading of 0 indicated full extension. These readings were used to update the positions of the corresponding finger groups of a virtual hand presented on a screen in front of Monkey N. Bend sensor values were sampled at 1000 Hz. Updates to the virtual hand were limited to the refresh rate of the monitor (120 Hz). The task itself involved trial-based target acquisitions. At the beginning of each trial, two color-coded spherical targets, one for each DOF, were placed on the screen, covering 15% of the full arc of motion (see Figure 1A). Monkey N then acquired the targets by moving his fingers to the correct positions and holding his position for 750 ms.

Modern multimodal large language models (MLLMs) can reason over hour-long video, yet their key-value (KV) cache grows linearly with time--quickly exceeding the fixed memory of phones, AR glasses, and edge robots. Prior compression schemes either assume the whole video and user query are available offline or must first build the full cache, so memory still scales with stream length. InfiniPot-V is the first training-free, query-agnostic framework that enforces a hard, lengthindependent memory cap for streaming video understanding. During video encoding it monitors the cache and, once a user-set threshold is reached, runs a lightweight compression pass that (i) removes temporally redundant tokens via Temporal-axis Redundancy (TaR) metric and (ii) keeps semantically significant tokens via Value-Norm (VaN) ranking. Across four open-source MLLMs and four long-video and streaming-video benchmarks, InfiniPot-V cuts peak GPU memory by up to 94%, sustains real-time generation, and matches or surpasses full-cache accuracy--even in multi-turn dialogues. By dissolving the KV cache bottleneck without retraining or query knowledge, InfiniPot-V closes the gap for on-device streaming video assistants.