While synthetic data hold great promise for privacy protection, their statistical analysis poses significant challenges that necessitate innovative solutions. The use of deep generative models (DGMs) for synthetic data generation is known to induce considerable bias and imprecision into synthetic data analyses, compromising their inferential utility as opposed to original data analyses. This bias and uncertainty can be substantial enough to impede statistical convergence rates, even in seemingly straightforward analyses like mean calculation.

A major challenge of the long measurement times in magnetic resonance imaging (MRI), an important medical imaging technology, is that patients may move during data acquisition. This leads to severe motion artifacts in the reconstructed images and volumes. In this paper, we propose MotionTTT a deep learning-based test-time-training (TTT) method for accurate motion estimation. The key idea is that a neural network trained for motion-free reconstruction has a small loss if there is no motion, thus optimizing over motion parameters passed through the reconstruction network enables accurate estimation of motion. The estimated motion parameters enable to correct for the motion and to reconstruct accurate motion-corrected images. Our method uses 2D reconstruction networks to estimate rigid motion in 3D, and constitutes the first deep learning based method for 3D rigid motion estimation towards 3D-motion-corrected MRI. We show that our method can provably reconstruct motion parameters for a simple signal and neural network model. We demonstrate the effectiveness of our method for both retrospectively simulated motion and prospectively collected real motion-corrupted data.

Molecular dynamics (MD) is a powerful technique for studying microscopic phenomena, but its computational cost has driven significant interest in the development of deep learning-based surrogate models. We introduce generative modeling of molecular trajectories as a paradigm for learning flexible multi-task surrogate models of MD from data. By conditioning on appropriately chosen frames of the trajectory, we show such generative models can be adapted to diverse tasks such as forward simulation, transition path sampling, and trajectory upsampling. By alternatively conditioning on part of the molecular system and inpainting the rest, we also demonstrate the first steps towards dynamics-conditioned molecular design. We validate the full set of these capabilities on tetrapeptide simulations and show preliminary results on scaling to protein monomers. Altogether, our work illustrates how generative modeling can unlock value from MD data towards diverse downstream tasks that are not straightforward to address with existing methods or even MD itself. Code is available at https://github.com/bjing2016/mdgen.

Despite advances in AI alignment, large language models (LLMs) remain vulnerable to adversarial attacks or jailbreaking, in which adversaries can modify prompts to induce unwanted behavior. While some defenses have been proposed, they have not been adapted to newly proposed attacks and more challenging threat models. To address this, we propose an optimization-based objective for defending LLMs against jailbreaking attacks and an algorithm, Robust Prompt Optimization (RPO), to create robust system-level defenses. Our approach directly incorporates the adversary into the defensive objective and optimizes a lightweight and transferable suffix, enabling RPO to adapt to worst-case adaptive attacks. Our theoretical and experimental results show improved robustness to both jailbreaks seen during optimization and unknown jailbreaks, reducing the attack success rate (ASR) on GPT-4 to 6% and Llama-2 to 0% on JailbreakBench, setting the state-of-the-art.

The company is reportedly making a unified app to streamline the user experience. OpenAI is developing a "super app" for desktop that unifies ChatGPT, its browser and its Codex app, according to the and . A company spokesperson told the publications that OpenAI Chief of Applications Fidji Simo will lead the application revamp with assistance from OpenAI President Greg Brockman. Simo will also help the marketing team advertise the app when it comes out. OpenAI's leadership is apparently hoping that combining several products can help it streamline user experience and dedicate its resources to one project.

Deep learning models can exhibit what appears to be a sudden ability to solve a new problem as training time, training data, or model size increases, a phenomenon known as emergence. In this paper, we present a framework where each new ability (a skill) is represented as a basis function. We solve a simple multi-linear model in this skill-basis, finding analytic expressions for the emergence of new skills, as well as for scaling laws of the loss with training time, data size, model size, and optimal compute. We compare our detailed calculations to direct simulations of a two-layer neural network trained on multitask sparse parity, where the tasks in the dataset are distributed according to a power-law. Our simple model captures, using a single fit parameter, the sigmoidal emergence of multiple new skills as training time, data size or model size increases in the neural network.

Test-time adaptation (TTA) is the most realistic methodology for adapting deep learning models to the real world using only unlabeled data from the target domain. Numerous TTA studies in deep learning have aimed at minimizing entropy. However, this necessitates forward/backward processes across the entire model and is limited by the incapability to fully leverage data based solely on entropy. This study presents a groundbreaking TTA solution that involves a departure from the conventional focus on minimizing entropy. Our innovative approach uniquely remodels the stem layer (i.e., the first layer) to emphasize minimizing a new learning criterion, namely, uncertainty.

High-dimensional data commonly lies on low-dimensional submanifolds, and estimating the local intrinsic dimension (LID) of a datum -- i.e. the dimension of the submanifold it belongs to -- is a longstanding problem. LID can be understood as the number of local factors of variation: the more factors of variation a datum has, the more complex it tends to be. Estimating this quantity has proven useful in contexts ranging from generalization in neural networks to detection of out-of-distribution data, adversarial examples, and AI-generated text. The recent successes of deep generative models present an opportunity to leverage them for LID estimation, but current methods based on generative models produce inaccurate estimates, require more than a single pre-trained model, are computationally intensive, or do not exploit the best available deep generative models: diffusion models (DMs). In this work, we show that the Fokker-Planck equation associated with a DM can provide an LID estimator which addresses the aforementioned deficiencies.

Deep learning models have become the dominant approach for multivariate time series anomaly detection (MTSAD), often reporting substantial performance improvements over classical statistical methods. However, these gains are frequently evaluated under heterogeneous thresholding strategies and evaluation protocols, making fair comparisons difficult. This work revisits OmniAnomaly, a widely used stochastic recurrent model for MTSAD, and systematically compares it with a simple linear baseline based on Principal Component Analysis (PCA) on the Server Machine Dataset (SMD). Both methods are evaluated under identical thresholding and evaluation procedures, with experiments repeated across 100 runs for each of the 28 machines in the dataset. Performance is evaluated using Precision, Recall and F1-score at point-level, with and without point-adjustment, and under different aggregation strategies across machines and runs, with the corresponding standard deviations also reported. The results show large variability across machines and show that PCA can achieve performance comparable to OmniAnomaly, and even outperform it when point-adjustment is not applied. These findings question the added value of more complex architectures under current benchmarking practices and highlight the critical role of evaluation methodology in MTSAD research.

Standard decoding strategies for text generation, including top-k, nucleus sampling, and contrastive search, select tokens based on likelihood, restricting selection to high-probability regions. Human language production operates differently: tokens are chosen for communicative appropriateness rather than statistical frequency. This mismatch creates a truncation blind spot: contextually appropriate but statistically rare tokens remain accessible to humans yet unreachable by likelihood-based decoding. We hypothesize this contributes to the detectability of machine-generated text. Analyzing over 1.8 million texts across eight language models, five decoding strategies, and 53 hyperparameter configurations, we find that 8-18% of human-selected tokens fall outside typical truncation boundaries. Simple classifiers trained on predictability and lexical diversity achieve remarkable detection rates. Crucially, neither model scale nor architecture correlates strongly with detectability; truncation parameters account for most variance. Configurations achieving low detectability often produce incoherent text, indicating that evading detection and producing natural text are distinct objectives. These findings suggest detectability is enhanced by likelihood-based token selection, not merely a matter of model capability.