Deep neural networks (DNNs) can enable precise control while maintaining low computational costs by circumventing the need for dynamic modeling. However, the deployment of such black-box approaches remains challenging for heavy-duty wheeled mobile robots (WMRs), which are subject to strict international standards and prone to faults and disturbances. We designed a hierarchical control policy for heavy-duty WMRs, monitored by two safety layers with differing levels of authority. To this end, a DNN policy was trained and deployed as the primary control strategy, providing high-precision performance under nominal operating conditions. When external disturbances arise and reach a level of intensity such that the system performance falls below a predefined threshold, a low-level safety layer intervenes by deactivating the primary control policy and activating a model-free robust adaptive control (RAC) policy. This transition enables the system to continue operating while ensuring stability by effectively managing the inherent trade-off between system robustness and responsiveness. Regardless of the control policy in use, a high-level safety layer continuously monitors system performance during operation. It initiates a shutdown only when disturbances become sufficiently severe such that compensation is no longer viable and continued operation would jeopardize the system or its environment. The proposed synthesis of DNN and RAC policy guarantees uniform exponential stability of the entire WMR system while adhering to safety standards to some extent. The effectiveness of the proposed approach was further validated through real-time experiments using a 6,000 kg WMR.

Predicting changes in binding free energy ($ΔΔG$) is a vital task in protein engineering and protein-protein interaction (PPI) engineering for drug discovery. Previous works have observed a high correlation between $ΔΔG$ and entropy, using probabilities of biologically important objects such as side chain angles and residue identities to estimate $ΔΔG$. However, estimating the full conformational distribution of a protein complex is generally considered intractable. In this work, we propose a new approach to $ΔΔG$ prediction that avoids this issue by instead leveraging energy-based models for estimating the probability of a complex's conformation. Specifically, we novelly decompose $ΔΔG$ into a sequence-based component estimated by an inverse folding model and a structure-based component estimated by an energy model. This decomposition is made tractable by assuming equilibrium between the bound and unbound states, allowing us to simplify the estimation of degeneracies associated with each state. Unlike previous deep learning-based methods, our method incorporates an energy-based physical inductive bias by connecting the often-used sequence log-odds ratio-based approach to $ΔΔG$ prediction with a new $ΔΔE$ term grounded in statistical mechanics. We demonstrate superiority over existing state-of-the-art structure and sequence-based deep learning methods in $ΔΔG$ prediction and antibody optimization against SARS-CoV-2.

Split Learning (SL) is a collaborative learning approach that improves privacy by keeping data on the client-side while sharing only the intermediate output with a server. However, the distributed nature of SL introduces new security challenges, necessitating a comprehensive exploration of potential attacks. This paper systematically reviews various attacks on SL, classifying them based on factors such as the attacker's role, the type of privacy risks, when data leaks occur, and where vulnerabilities exist. We also analyze existing defense methods, including cryptographic methods, data modification approaches, distributed techniques, and hybrid solutions. Our findings reveal security gaps, highlighting the effectiveness and limitations of existing defenses. By identifying open challenges and future directions, this work provides valuable information to improve SL privacy issues and guide further research.

Deep learning models often struggle to maintain generalizability in medical imaging, particularly under domain-fracture scenarios where distribution shifts arise from varying imaging techniques, acquisition protocols, patient populations, demographics, and equipment. In practice, each hospital may need to train distinct models - differing in learning task, width, and depth - to match local data. For example, one hospital may use Euclidean architectures such as MLPs and CNNs for tabular or grid-like image data, while another may require non-Euclidean architectures such as graph neural networks (GNNs) for irregular data like brain connectomes. How to train such heterogeneous models coherently across datasets, while enhancing each model's generalizability, remains an open problem. We propose unified learning, a new paradigm that encodes each model into a graph representation, enabling unification in a shared graph learning space. A GNN then guides optimization of these unified models. By decoupling parameters of individual models and controlling them through a unified GNN (uGNN), our method supports parameter sharing and knowledge transfer across varying architectures (MLPs, CNNs, GNNs) and distributions, improving generalizability. Evaluations on MorphoMNIST and two MedMNIST benchmarks - PneumoniaMNIST and BreastMNIST - show that unified learning boosts performance when models are trained on unique distributions and tested on mixed ones, demonstrating strong robustness to unseen data with large distribution shifts. Code and benchmarks: https://github.com/basiralab/uGNN

This paper presents a feasibility study on the deployment of a European Deep Inference Fabric (eDIF), an NDIF-compatible infrastructure designed to support mechanistic interpretability research on large language models. The need for widespread accessibility of LLM interpretability infrastructure in Europe drives this initiative to democratize advanced model analysis capabilities for the research community. The project introduces a GPU-based cluster hosted at Ansbach University of Applied Sciences and interconnected with partner institutions, enabling remote model inspection via the NNsight API. A structured pilot study involving 16 researchers from across Europe evaluated the platform's technical performance, usability, and scientific utility. Users conducted interventions such as activation patching, causal tracing, and representation analysis on models including GPT-2 and DeepSeek-R1-70B. The study revealed a gradual increase in user engagement, stable platform performance throughout, and a positive reception of the remote experimentation capabilities. It also marked the starting point for building a user community around the platform. Identified limitations such as prolonged download durations for activation data as well as intermittent execution interruptions are addressed in the roadmap for future development. This initiative marks a significant step towards widespread accessibility of LLM interpretability infrastructure in Europe and lays the groundwork for broader deployment, expanded tooling, and sustained community collaboration in mechanistic interpretability research.

Reward sparsity in long-horizon reinforcement learning (RL) tasks remains a significant challenge, while existing outcome-based reward shaping struggles to define meaningful immediate rewards without introducing bias or requiring explicit task decomposition. Alternatively, verification-based reward shaping uses stepwise critics, but misalignment between immediate rewards and long-term objectives can lead to reward hacking and suboptimal policies. In this work, we address this problem in the context of software engineering (SWE) tasks, where multi-turn reasoning and rule-based verification are critical. We introduce the SWE-oriented RL Framework, a unified system supporting multi-turn interaction, docker-based execution, and customizable reward functions. Additionally, we propose Gated Reward Accumulation (G-RA), a novel method that accumulates immediate rewards only when high-level (long-term) rewards meet a predefined threshold, ensuring stable RL optimization. Experiments on SWE-bench V eri-fied and kBench demonstrate that G-RA leads to an increase in completion rates (47.6% 93.8% and 22.0% 86.0%) and modification rates (19.6% 23.8% and 12.0% 42.0%), while avoiding policy degradation caused by reward misalignment. Our findings highlight the importance of balanced reward accumulation in long-horizon RL and provide a practical solution.

Optimizing or sampling complex cost functions of combinatorial optimization problems is a longstanding challenge across disciplines and applications. When employing family of conventional algorithms based on Markov Chain Monte Carlo (MCMC) such as simulated annealing or parallel tempering, one assumes homogeneous (equilibrium) temperature profiles across input. This instance independent approach was shown to be ineffective for the hardest benchmarks near a computational phase transition when the so-called overlap-gap-property holds. In these regimes conventional MCMC struggles to unfreeze rigid variables, escape suboptimal basins of attraction, and sample high-quality and diverse solutions. In order to mitigate these challenges, Nonequilibrium Nonlocal Monte Carlo (NMC) algorithms were proposed that leverage inhomogeneous temperature profiles thereby accelerating exploration of the configuration space without compromising its exploitation. Here, we employ deep reinforcement learning (RL) to train the nonlocal transition policies of NMC which were previously designed phenomenologically. We demonstrate that the resulting solver can be trained solely by observing energy changes of the configuration space exploration as RL rewards and the local minimum energy landscape geometry as RL states. We further show that the trained policies improve upon the standard MCMC-based and nonlocal simulated annealing on hard uniform random and scale-free random 4-SAT benchmarks in terms of residual energy, time-to-solution, and diversity of solutions metrics.

Recent advances in 3D Gaussian splatting have significantly improved real-time novel view synthesis, yet insufficient geometric constraints during scene optimization often result in blurred reconstructions of fine-grained details, particularly in regions with high-frequency textures and sharp discontinuities. To address this, we propose a comprehensive optimization framework integrating multisample anti-aliasing (MSAA) with dual geometric constraints. Our system computes pixel colors through adaptive blending of quadruple subsamples, effectively reducing aliasing artifacts in high-frequency components. The framework introduces two constraints: (a) an adaptive weighting strategy that prioritizes under-reconstructed regions through dynamic gradient analysis, and (b) gradient differential constraints enforcing geometric regularization at object boundaries. This targeted optimization enables the model to allocate computational resources preferentially to critical regions requiring refinement while maintaining global consistency. Extensive experimental evaluations across multiple benchmarks demonstrate that our method achieves state-of-the-art performance in detail preservation, particularly in preserving high-frequency textures and sharp discontinuities, while maintaining real-time rendering efficiency. Quantitative metrics and perceptual studies confirm statistically significant improvements over baseline approaches in both structural similarity (SSIM) and perceptual quality (LPIPS).

Full-process clinical diagnosis in the real world encompasses the entire diagnostic workflow that begins with only an ambiguous chief complaint. While artificial intelligence (AI), particularly large language models (LLMs), is transforming clinical diagnosis, its role remains largely as an assistant to physicians. This AI-assisted working pattern makes AI can only answer specific medical questions at certain parts within the diagnostic process, but lack the ability to drive the entire diagnostic process starting from an ambiguous complaint, which still relies heavily on human physicians. This gap limits AI's ability to fully reduce physicians' workload and enhance diagnostic efficiency. To address this, we propose a paradigm shift that reverses the relationship between physicians and AI: repositioning AI as the primary director, with physicians serving as its assistants. So we present DxDirector-7B, an LLM endowed with advanced deep thinking capabilities, enabling it to drive the full-process diagnosis with minimal physician involvement. Furthermore, DxDirector-7B establishes a robust accountability framework for misdiagnoses, delineating responsibility between AI and human physicians. In evaluations across rare, complex, and real-world cases under full-process diagnosis setting, DxDirector-7B not only achieves significant superior diagnostic accuracy but also substantially reduces physician workload than state-of-the-art medical LLMs as well as general-purpose LLMs. Fine-grained analyses across multiple clinical departments and tasks validate its efficacy, with expert evaluations indicating its potential to serve as a viable substitute for medical specialists. These findings mark a new era where AI, traditionally a physicians' assistant, now drives the entire diagnostic process to drastically reduce physicians' workload, indicating an efficient and accurate diagnostic solution.

Although one-hot encoding is commonly used for multiclass classification, it is not always the most effective encoding mechanism. Error Correcting Output Codes (ECOC) address multiclass classification by mapping each class to a unique codeword used as a label. Traditional ECOC methods rely on manually designed or randomly generated codebooks, which are labor-intensive and may yield suboptimal, dataset-agnostic results. This paper introduces three models for automated codebook learning based on contrastive learning, allowing codebooks to be learned directly and adaptively from data. Across four datasets, our proposed models demonstrate superior robustness to adversarial attacks compared to two baselines. The source is available at https://github.com/YuChou20/Automated-Codebook-Learning-with-Error-Correcting-Output-Code-Technique.