Modeling & Simulation (M&S) approaches such as agent-based models hold significant potential to support decision-making activities in health, with recent examples including the adoption of vaccines, and a vast literature on healthy eating behaviors and physical activity behaviors. These models are potentially usable by different stakeholder groups, as they support policy-makers to estimate the consequences of potential interventions and they can guide individuals in making healthy choices in complex environments. However, this potential may not be fully realized because of the models' complexity, which makes them inaccessible to the stakeholders who could benefit the most. While Large Language Models (LLMs) can translate simulation outputs and the design of models into text, current approaches typically rely on one-size-fits-all summaries that fail to reflect the varied informational needs and stylistic preferences of clinicians, policy-makers, patients, caregivers, and health advocates. This limitation stems from a fundamental gap: we lack a systematic understanding of what these stakeholders need from explanations and how to tailor them accordingly. To address this gap, we present a step-by-step framework to identify stakeholder needs and guide LLMs in generating tailored explanations of health simulations. Our procedure uses a mixed-methods design by first eliciting the explanation needs and stylistic preferences of diverse health stakeholders, then optimizing the ability of LLMs to generate tailored outputs (e.g., via controllable attribute tuning), and then evaluating through a comprehensive range of metrics to further improve the tailored generation of summaries.

Traffic congestion and violations pose significant challenges for urban mobility and road safety. Traditional traffic monitoring systems, such as fixed cameras and sensor-based methods, are often constrained by limited coverage, low adaptability, and poor scalability. To address these challenges, this paper introduces an advanced unmanned aerial vehicle (UAV)-based traffic surveillance system capable of accurate vehicle detection, classification, tracking, and behavioral analysis in real-world, unconstrained urban environments. The system leverages multi-scale and multi-angle template matching, Kalman filtering, and homography-based calibration to process aerial video data collected from altitudes of approximately 200 meters. A case study in urban area demonstrates robust performance, achieving a detection precision of 91.8%, an F1-score of 90.5%, and tracking metrics (MOTA/MOTP) of 92.1% and 93.7%, respectively. Beyond precise detection, the system classifies five vehicle types and automatically detects critical traffic violations, including unsafe lane changes, illegal double parking, and crosswalk obstructions, through the fusion of geofencing, motion filtering, and trajectory deviation analysis. The integrated analytics module supports origin-destination tracking, vehicle count visualization, inter-class correlation analysis, and heatmap-based congestion modeling. Additionally, the system enables entry-exit trajectory profiling, vehicle density estimation across road segments, and movement direction logging, supporting comprehensive multi-scale urban mobility analytics. Experimental results confirms the system's scalability, accuracy, and practical relevance, highlighting its potential as an enforcement-aware, infrastructure-independent traffic monitoring solution for next-generation smart cities.

Multimodal foundation models can process several modalities. However, since the space of possible modalities is large and evolving over time, training a model from scratch to encompass all modalities is unfeasible. Moreover, integrating a modality into a pre-existing foundation model currently requires a significant amount of paired data, which is often not available for low-resource modalities. In this paper, we introduce a method for sample-efficient modality integration (SEMI) into Large Language Models (LLMs). To this end, we devise a hypernetwork that can adapt a shared projector -- placed between modality-specific encoders and an LLM -- to any modality. The hypernetwork, trained on high-resource modalities (i.e., text, speech, audio, video), is conditioned on a few samples from any arbitrary modality at inference time to generate a suitable adapter. To increase the diversity of training modalities, we artificially multiply the number of encoders through isometric transformations. We find that SEMI achieves a significant boost in sample efficiency during few-shot integration of new modalities (i.e., satellite images, astronomical images, inertial measurements, and molecules) with encoders of arbitrary embedding dimensionality. For instance, to reach the same accuracy as 32-shot SEMI, training the projector from scratch needs 64$\times$ more data. As a result, SEMI holds promise to extend the modality coverage of foundation models.

Sarcasm, a common feature of human communication, poses challenges in interpersonal interactions and human-machine interactions. Linguistic research has highlighted the importance of prosodic cues, such as variations in pitch, speaking rate, and intonation, in conveying sarcastic intent. Although previous work has focused on text-based sarcasm detection, the role of speech data in recognizing sarcasm has been underexplored. Recent advancements in speech technology emphasize the growing importance of leveraging speech data for automatic sarcasm recognition, which can enhance social interactions for individuals with neurodegenerative conditions and improve machine understanding of complex human language use, leading to more nuanced interactions. This systematic review is the first to focus on speech-based sarcasm recognition, charting the evolution from unimodal to multimodal approaches. It covers datasets, feature extraction, and classification methods, and aims to bridge gaps across diverse research domains. The findings include limitations in datasets for sarcasm recognition in speech, the evolution of feature extraction techniques from traditional acoustic features to deep learning-based representations, and the progression of classification methods from unimodal approaches to multimodal fusion techniques. In so doing, we identify the need for greater emphasis on cross-cultural and multilingual sarcasm recognition, as well as the importance of addressing sarcasm as a multimodal phenomenon, rather than a text-based challenge.

Prediction for ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) plays a crucial role in drug discovery and development, accelerating the screening and optimization of new drugs. Existing methods primarily rely on single-task learning (STL), which often fails to fully exploit the complementarities between tasks. Besides, it requires more computational resources while training and inference of each task independently. To address these issues, we propose a new unified Q uantum-enhanced and task-W eighted Multi-Task L earning ( QW-MTL) framework, specifically designed for ADMET classification tasks. Built upon the Chemprop-RDKit backbone, QW-MTL adopts quantum chemical descriptors to enrich molecular representations with additional information about the electronic structure and interactions. Meanwhile, it introduces a novel exponential task weighting scheme that combines dataset-scale priors with learnable parameters to achieve dynamic loss balancing across tasks. To the best of our knowledge, this is the first work to systematically conduct joint multi-task training across all 13 Therapeutics Data Commons (TDC) classification benchmarks, using leaderboard-style data splits to ensure a standardized and realistic evaluation setting. Extensive experimental results show that QW-MTL significantly outperforms single-task baselines on 12 out of 13 tasks, achieving high predictive performance with minimal model complexity and fast inference, demonstrating the effectiveness and efficiency of multi-task molecular learning enhanced by quantum-informed features and adaptive task weighting.

We propose an instance-wise adaptive sampling framework for constructing compact and informative training datasets for supervised learning of inverse problem solutions. Typical learning-based approaches aim to learn a general-purpose inverse map from datasets drawn from a prior distribution, with the training process independent of the specific test instance. When the prior has a high intrinsic dimension or when high accuracy of the learned solution is required, a large number of training samples may be needed, resulting in substantial data collection costs. In contrast, our method dynamically allocates sampling effort based on the specific test instance, enabling significant gains in sample efficiency. By iteratively refining the training dataset conditioned on the latest prediction, the proposed strategy tailors the dataset to the geometry of the inverse map around each test instance. We demonstrate the effectiveness of our approach in the inverse scattering problem under two types of structured priors. Our results show that the advantage of the adaptive method becomes more pronounced in settings with more complex priors or higher accuracy requirements. While our experiments focus on a particular inverse problem, the adaptive sampling strategy is broadly applicable and readily extends to other inverse problems, offering a scalable and practical alternative to conventional fixed-dataset training regimes.

Transformer-based language models excel in NLP tasks, but fine-grained control remains challenging. This paper explores methods for manipulating transformer models through principled interventions at three levels: prompts, activations, and weights. We formalize controllable text generation as an optimization problem addressable via prompt engineering, parameter-efficient fine-tuning, model editing, and reinforcement learning. We introduce a unified framework encompassing prompt-level steering, activation interventions, and weight-space edits. We analyze robustness and safety implications, including adversarial attacks and alignment mitigations. Theoretically, we show minimal weight updates can achieve targeted behavior changes with limited side-effects. Empirically, we demonstrate >90% success in sentiment control and factual edits while preserving base performance, though generalization-specificity trade-offs exist. We discuss ethical dual-use risks and the need for rigorous evaluation. This work lays groundwork for designing controllable and robust language models.

Large language models have demonstrated remarkable capabilities in biomedical natural language processing, yet their rapid growth in size and computational requirements present a major barrier to adoption in healthcare settings where data privacy precludes cloud deployment and resources are limited. In this study, we systematically evaluated the impact of quantization on 12 state-of-the-art large language models, including both general-purpose and biomedical-specific models, across eight benchmark datasets covering four key tasks: named entity recognition, relation extraction, multi-label classification, and question answering. We show that quantization substantially reduces GPU memory requirements-by up to 75%-while preserving model performance across diverse tasks, enabling the deployment of 70B-parameter models on 40GB consumer-grade GPUs. In addition, domain-specific knowledge and responsiveness to advanced prompting methods are largely maintained. These findings provide significant practical and guiding value, highlighting quantization as a practical and effective strategy for enabling the secure, local deployment of large yet high-capacity language models in biomedical contexts, bridging the gap between technical advances in AI and real-world clinical translation.

Colombia has been submerged in decades of armed conflict, yet until recently, the systematic documentation of violence was not a priority for the Colombian government. This has resulted in a lack of publicly available conflict information and, consequently, a lack of historical accounts. This study contributes to Colombia's historical memory by utilizing GPT, a large language model (LLM), to read and answer questions about over 200,000 violence-related newspaper articles in Spanish. We use the resulting dataset to conduct both descriptive analysis and a study of the relationship between violence and the eradication of coca crops, offering an example of policy analyses that such data can support. Our study demonstrates how LLMs have opened new research opportunities by enabling examinations of large text corpora at a previously infeasible depth.

Extracting structured clinical information from radiology reports is challenging, especially in low-resource languages. This is pronounced in Crohn's disease, with sparsely represented multi-organ findings. We developed Hierarchical Structured Matching Prediction BERT (HSMP-BERT), a prompt-based model for extraction from Hebrew radiology text. In an administrative database study, we analyzed 9,683 reports from Crohn's patients imaged 2010-2023 across Israeli providers. A subset of 512 reports was radiologist-annotated for findings across six gastrointestinal organs and 15 pathologies, yielding 90 structured labels per subject. Multilabel-stratified split (66% train+validation; 33% test), preserving label prevalence. Performance was evaluated with accuracy, F1, Cohen's $κ$, AUC, PPV, NPV, and recall. On 24 organ-finding combinations with $>$15 positives, HSMP-BERT achieved mean F1 0.83$\pm$0.08 and $κ$ 0.65$\pm$0.17, outperforming the SMP zero-shot baseline (F1 0.49$\pm$0.07, $κ$ 0.06$\pm$0.07) and standard fine-tuning (F1 0.30$\pm$0.27, $κ$ 0.27$\pm$0.34; paired t-test $p < 10^{-7}$). Hierarchical inference cuts runtime 5.1$\times$ vs. traditional inference. Applied to all reports, it revealed associations among ileal wall thickening, stenosis, and pre-stenotic dilatation, plus age- and sex-specific trends in inflammatory findings. HSMP-BERT offers a scalable solution for structured extraction in radiology, enabling population-level analysis of Crohn's disease and demonstrating AI's potential in low-resource settings.