Large language models (LLMs) have recently been proposed as general-purpose agents for experimental design, with claims that they can perform in-context experimental design. We evaluate this hypothesis using both open- and closed-source instruction-tuned LLMs applied to genetic perturbation and molecular property discovery tasks. We find that LLM-based agents show no sensitivity to experimental feedback: replacing true outcomes with randomly permuted labels has no impact on performance. Across benchmarks, classical methods such as linear bandits and Gaussian process optimization consistently outperform LLM agents. We further propose a simple hybrid method, LLM-guided Nearest Neighbour (LLMNN) sampling, that combines LLM prior knowledge with nearest-neighbor sampling to guide the design of experiments. LLMNN achieves competitive or superior performance across domains without requiring significant in-context adaptation. These results suggest that current open- and closed-source LLMs do not perform in-context experimental design in practice and highlight the need for hybrid frameworks that decouple prior-based reasoning from batch acquisition with updated posteriors.

Abstract--This article presents mmHSense, a set of open labeled mmWave datasets to support human sensing research within Integrated Sensing and Communication (ISAC) systems. The datasets can be used to explore mmWave ISAC for various end applications such as gesture recognition, person identification, pose estimation, and localization. Moreover, the datasets can be used to develop and advance signal processing and deep learning research on mmWave ISAC. This article describes the testbed, experimental settings, and signal features for each dataset. Furthermore, the utility of the datasets is demonstrated through validation on a specific downstream task. In addition, we demonstrate the use of parameter-efficient fine-tuning to adapt ISAC models to different tasks, significantly reducing computational complexity while maintaining performance on prior tasks. Integrated Sensing and Communication (ISAC) [1] enables communication networks to double as intelligent sensing systems, enabling advance human sensing applications. For instance, ISAC can enable Wi-Fi routers to recognize human gestures in smart-home applications [2].

Abstract--The rapid development of generative artificial intelligence (AI) has introduced significant opportunities for enhancing the efficiency and accuracy of image transmission within semantic communication systems. T o address this issue, we introduce an innovative generative semantic communication system that refines semantic granularity by segmenting images into key and non-key regions. Key regions, which contain essential visual information, are processed using an image oriented semantic encoder, while non-key regions are efficiently compressed through an image-to-text modeling approach. Additionally, to mitigate the substantial storage and computational demands posed by large AI models, the proposed system employs a lightweight deployment strategy incorporating model quantization and low-rank adaptation fine-tuning techniques, significantly boosting resource utilization without sacrificing performance. Simulation results demonstrate that the proposed system outperforms traditional methods in terms of both semantic fidelity and visual quality, thereby affirming its effectiveness for image transmission tasks.

Large Language Models (LLMs) have achieved impressive performance across a wide range of applications. However, they often suffer from hallucinations in knowledge-intensive domains due to their reliance on static pretraining corpora. To address this limitation, Retrieval-Augmented Generation (RAG) enhances LLMs by incorporating external knowledge sources during inference. Among these sources, textual graphs provide structured and semantically rich information that supports more precise and interpretable reasoning. This has led to growing interest in graph-based RAG systems. Despite their potential, most existing approaches rely on a single retriever to identify relevant subgraphs, which limits their ability to capture the diverse aspects of complex queries. Moreover, these systems often struggle to accurately judge the relevance of retrieved content, making them prone to distraction by irrelevant noise. To address these challenges, in this paper, we propose MIXRAG, a Mixture-of-Experts Graph-RAG framework that introduces multiple specialized graph retrievers and a dynamic routing controller to better handle diverse query intents. Each retriever is trained to focus on a specific aspect of graph semantics, such as entities, relations, or subgraph topology. A Mixture-of-Experts module adaptively selects and fuses relevant retrievers based on the input query. To reduce noise in the retrieved information, we introduce a query-aware GraphEncoder that carefully analyzes relationships within the retrieved subgraphs, highlighting the most relevant parts while down-weighting unnecessary noise. Empirical results demonstrate that our method achieves state-of-the-art performance and consistently outperforms various baselines. MIXRAG is effective across a wide range of graph-based tasks in different domains. The code will be released upon paper acceptance.

Concept Bottleneck Models (CBMs) use a set of human-interpretable concepts to predict the final task label, enabling domain experts to not only validate the CBM's predictions, but also intervene on incorrect concepts at test time. However, these interventions fail to address systemic misalignment between the CBM and the expert's reasoning, such as when the model learns shortcuts from biased data. To address this, we present a general interpretable debugging framework for CBMs that follows a two-step process of Removal and Retraining. In the Removal step, experts use concept explanations to identify and remove any undesired concepts. In the Retraining step, we introduce CBDebug, a novel method that leverages the interpretability of CBMs as a bridge for converting concept-level user feedback into sample-level auxiliary labels. These labels are then used to apply supervised bias mitigation and targeted augmentation, reducing the model's reliance on undesired concepts. We evaluate our framework with both real and automated expert feedback, and find that CBDebug significantly outperforms prior retraining methods across multiple CBM architectures (PIP-Net, Post-hoc CBM) and benchmarks with known spurious correlations.

Risk-adapted breast cancer screening requires robust models that leverage longitudinal imaging data. Most current deep learning models use single or limited prior mammograms and lack adaptation for real-world settings marked by imbalanced outcome distribution and heterogeneous follow-up. We developed LongiMam, an end-to-end deep learning model that integrates both current and up to four prior mammograms. LongiMam combines a convolutional and a recurrent neural network to capture spatial and temporal patterns predictive of breast cancer. The model was trained and evaluated using a large, population-based screening dataset with disproportionate case-to-control ratio typical of clinical screening. Across several scenarios that varied in the number and composition of prior exams, LongiMam consistently improved prediction when prior mammograms were included. The addition of prior and current visits outperformed single-visit models, while priors alone performed less well, highlighting the importance of combining historical and recent information. Subgroup analyses confirmed the model's efficacy across key risk groups, including women with dense breasts and those aged 55 years or older. Moreover, the model performed best in women with observed changes in mammographic density over time. These findings demonstrate that longitudinal modeling enhances breast cancer prediction and support the use of repeated mammograms to refine risk stratification in screening programs. LongiMam is publicly available as open-source software.

Deep Learning models have transformed various domains, including the healthcare sector, particularly biomedical image classification by learning intricate features and enabling accurate diagnostics pertaining to complex diseases. Recent studies have adopted two different approaches to train DL models: training from scratch and transfer learning. Both approaches demand substantial computational time and resources due to the involvement of massive datasets in model training. These computational demands are further increased due to the design-space exploration required for selecting optimal hyperparameters, which typically necessitates several training rounds. With the growing sizes of datasets, exploring solutions to this problem has recently gained the research community's attention. A plausible solution is to select a subset of the dataset for training and hyperparameter search. This subset, referred to as the corset, must be a representative set of the original dataset. A straightforward approach to selecting the coreset could be employing random sampling, albeit at the cost of compromising the representativeness of the original dataset. A critical limitation of random sampling is the bias towards the dominant classes in an imbalanced dataset. Even if the dataset has inter-class balance, this random sampling will not capture intra-class diversity. This study addresses this issue by introducing an intelligent, lightweight mechanism for coreset selection. Specifically, it proposes a method to extract intra-class diversity, forming per-class clusters that are utilized for the final sampling. We demonstrate the efficacy of the proposed methodology by conducting extensive classification experiments on a well-known biomedical imaging dataset. Results demonstrate that the proposed scheme outperforms the random sampling approach on several performance metrics for uniform conditions.

Audiovisual embodied navigation enables robots to locate audio sources by dynamically integrating visual observations from onboard sensors with the auditory signals emitted by the target. The core challenge lies in effectively leveraging multimodal cues to guide navigation. While prior works have explored basic fusion of visual and audio data, they often overlook deeper perceptual context. To address this, we propose the Dynamic Multi-Target Fusion for Efficient Audio-Visual Navigation (DMTF-A VN). Our approach uses a multi-target architecture coupled with a refined Transformer mechanism to filter and selectively fuse cross-modal information. Extensive experiments on the Replica and Matterport3D datasets demonstrate that DMTF-A VN achieves state-of-the-art performance, outperforming existing methods in success rate (SR), path efficiency (SPL), and scene adaptation (SNA). Furthermore, the model exhibits strong scalability and generalizability, paving the way for advanced multimodal fusion strategies in robotic navigation.

The field of optical microscopy spans across numerous industries and research domains, ranging from education to healthcare, quality inspection and analysis. Nonetheless, a key limitation often cited by optical microscopists refers to the limit of its lateral resolution (typically defined as ~200nm), with potential circumventions involving either costly external modules (e.g. confocal scan heads, etc) and/or specialized techniques [e.g. super-resolution (SR) fluorescent microscopy]. Addressing these challenges in a normal (non-specialist) context thus remains an aspect outside the scope of most microscope users & facilities. This study thus seeks to evaluate an alternative & economical approach to achieving SR optical microscopy, involving non-fluorescent phase-modulated microscopical modalities such as Zernike phase contrast (PCM) and differential interference contrast (DIC) microscopy. Two in silico deep neural network (DNN) architectures which we developed previously (termed O-Net and Theta-Net) are assessed on their abilities to resolve a custom-fabricated test target containing nanoscale features calibrated via atomic force microscopy (AFM). The results of our study demonstrate that although both O-Net and Theta-Net seemingly performed well when super-resolving these images, they were complementary (rather than competing) approaches to be considered for image SR, particularly under different image signal-to-noise ratios (SNRs). High image SNRs favoured the application of O-Net models, while low SNRs inclined preferentially towards Theta-Net models. These findings demonstrate the importance of model architectures (in conjunction with the source image SNR) on model performance and the SR quality of the generated images where DNN models are utilized for non-fluorescent optical nanoscopy, even where the same training dataset & number of epochs are being used.

Text-to-image generation has advanced rapidly with large-scale multimodal training, yet fine-grained controllability remains a critical challenge. Counterfactual controllability, defined as the capacity to deliberately generate images that contradict common-sense patterns, remains a major challenge but plays a crucial role in enabling creativity and exploratory applications. In this work, we address this gap with a focus on counterfactual size (e.g., generating a tiny walrus beside a giant button) and propose an automatic prompt engineering framework that adapts base prompts into revised prompts for counterfactual images. The framework comprises three components: an image evaluator that guides dataset construction by identifying successful image generations, a supervised prompt rewriter that produces revised prompts, and a DPO-trained ranker that selects the optimal revised prompt. We construct the first counterfactual size text-image dataset and enhance the image evaluator by extending Grounded SAM with refinements, achieving a 114 percent improvement over its backbone. Experiments demonstrate that our method outperforms state-of-the-art baselines and ChatGPT-4o, establishing a foundation for future research on counterfactual controllability.