Multimodal large language models (MLLMs) are essential for building generalpurpose AI assistants; however, they pose increasing safety risks. How can we ensure safety alignment of MLLMs to prevent undesired behaviors? Going further, it is critical to explore how to fine-tune MLLMs to preserve capabilities while meeting safety constraints. Fundamentally, this challenge can be formulated as a min-max optimization problem. However, existing datasets have not yet disentangled single preference signals into explicit safety constraints, hindering systematic investigation in this direction. Moreover, it remains an open question whether such constraints can be effectively incorporated into the optimization process for multimodal models. In this work, we present the first exploration of the Safe RLHF-V - the first multimodal safety alignment framework. The framework consists of: (I) BeaverTails-V, the first open-source dataset featuring dual preference annotations for helpfulness and safety, supplemented with multi-level safety labels (minor, moderate, severe); (II) Beaver-Guard-V, a multi-level guardrail system to proactively defend against unsafe queries and adversarial attacks. Applying the guard model over five rounds of filtering and regeneration significantly enhances the precursor model's overall safety by an average of 40.9%.

Time series data in real-world applications such as healthcare, climate modeling, and finance are often irregular, multimodal, and messy, with varying sampling rates, asynchronous modalities, and pervasive missingness. However, existing benchmarks typically assume clean, regularly sampled, unimodal data, creating a significant gap between research and real-world deployment. We introduce TIME-IMM, a dataset specifically designed to capture cause-driven irregularity in multimodal multivariate time series. TIME-IMM represents nine distinct types of time series irregularity, categorized into trigger-based, constraint-based, and artifact-based mechanisms. Complementing the dataset, we introduce IMM-TSF, a benchmark library for forecasting on irregular multimodal time series, enabling asynchronous integration and realistic evaluation. IMM-TSF includes specialized fusion modules, including a timestamp-to-text fusion module and a multimodality fusion module, which support both recency-aware averaging and attention-based integration strategies. Empirical results demonstrate that explicitly modeling multimodality on irregular time series data leads to substantial gains in forecasting performance. TIME-IMM and IMM-TSF provide a foundation for advancing time series analysis under real-world conditions.

Scaling visual generation models is essential for real-world content creation, yet requires substantial training and computational expenses. Alternatively, test-time scaling has garnered growing attention due to resource efficiency and promising performance.

Flow matching is an emerging generative modeling framework that learns continuous-time dynamics to map noise into data. To enhance expressiveness and sampling efficiency, recent works have explored incorporating high-order trajectory information. Despite the empirical success, a holistic theoretical foundation is still lacking. We present a unified framework for standard and high-order flow matching that incorporates trajectory derivatives up to an arbitrary order K. Our key innovation is establishing the marginalization technique that converts the intractable K-order loss into a simple conditional regression with exact gradients and identifying the consistency constraint. We establish sharp statistical rates of the K-order flow matching implemented with transformer networks. With nsamples, flow matching estimates nonparametric distributions at a rate eO(n Θ(1/d)), matching minimax lower bounds up to logarithmic factors.

Prefix caching is a key technique for reducing Large Language Model (LLM) inference costs. However, the prevalent least-recently-used (LRU) eviction algorithm has a large gap to the optimal algorithm. This paper introduces LPC, the first learned method to perform LLM prefix cache eviction. LPC leverages conversational content analysis to provide predictive guidance for eviction, determining which conversations are likely to continue. These insights, combined with last access timestamps, inform more effective cache management. Extensive evaluations across three real-world datasets demonstrate that LPC achieves 18-47% reductions in required cache sizes for equivalent hit ratios and has an 11% improvement in LLM prefilling throughput in an emulated environment.

Retrieval-Augmented Generation (RAG) enhances Large Language Models by grounding their outputs in external documents. These systems, however, remain vulnerable to attacks on the retrieval corpus, such as prompt injection. RAG-based search systems (e.g., Google's Search AIOverview) present an interesting setting for studying and protecting against such threats, as defense algorithms can benefit from built-in reliability signals--like document ranking--and represent a non-LLM challenge for the adversary due to decades of work to thwart SEO. Motivated by, but not limited to, this scenario, this work introduces ReliabilityRAG, a framework for adversarial robustness that explicitly leverages reliability information of retrieved documents. Our first contribution adopts a graph-theoretic perspective to identify a "consistent majority" among retrieved documents to filter out malicious ones. We introduce a novel algorithm based on finding a Maximum Independent Set (MIS) on a document graph where edges encode contradiction. Our MIS variant explicitly prioritizes higher-reliability documents and provides provable robustness guarantees against bounded adversarial corruption under natural assumptions. Recognizing the computational cost of exact MIS for large retrieval sets, our second contribution is a scalable weighted sample and aggregate framework.

Training Long-Context Large Language Models (LLMs) is challenging, as hybrid training with long-context and short-context data often leads to workload imbalances. Existing works mainly use data packing to alleviate this issue, but fail to consider imbalanced attention computation and wasted communication overhead. This paper proposes Hierarchical Balance Packing (HBP), which designs a novel batch-construction method and training recipe to address those inefficiencies.

Spatial transcriptomics technologies can be used to align transcriptomes with histopathological morphology, presenting exciting new opportunities for biomolecular discovery. Using spatial transcriptomic gene expression and corresponding histology data, we construct a novel framework, GeneFlow, to map single-and multi-cell gene expression onto paired cellular images. By combining an attentionbased RNA encoder with a conditional UNet guided by rectified flow, we generate high-resolution images with different staining methods (e.g., H&E, DAPI) to highlight various cellular/ tissue structures. Rectified flow with high-order ODE solvers creates a continuous, bijective mapping between expression and image manifolds, addressing the many-to-one relationship inherent in this problem. Our method enables the generation of realistic cellular morphology features and spatially resolved intercellular interactions under genetic or chemical perturbations. This enables minimally invasive disease diagnosis by revealing dysregulated patterns in imaging phenotypes. Our rectified flow based method outperforms diffusion methods and baselines in all experiments.

Large Vision-Language Models (LVLMs) have demonstrated impressive capabilities in tasks requiring multimodal understanding. However, recent studies indicate that LVLMs are more vulnerable than LLMs to unsafe inputs and prone to generating harmful content. Existing defense strategies primarily include fine-tuning, input sanitization, and output intervention. Although these approaches provide a certain level of protection, they tend to be resource-intensive and struggle to effectively counter sophisticated attack techniques. To tackle such issues, we propose One-head Defense (Oh Defense), a novel yet simple approach utilizing LVLMs' internal safety capabilities. Through systematic analysis of the attention mechanisms, we discover that LVLMs' safety capabilities are concentrated within specific attention heads that respond differently to safe or unsafe inputs. Further exploration reveals that a single critical attention head can effectively serve as a safety guard, providing a strong discriminative signal that amplifies the model's inherent safety capabilities. Hence, the Oh Defense requires no additional training or external modules, making it computationally efficient while effectively reactivating suppressed safety mechanisms. Extensive experiments across diverse LVLM architectures and unsafe datasets validate our approach, i.e., the Oh Defense achieves near-perfect defense success rates (> 98%) for unsafe inputs while maintaining low false positive rates (< 5%) for safe content.

Long-horizon video-audio reasoning and fine-grained pixel understanding impose conflicting requirements on omnimodal models: dense temporal coverage demands many low-resolution frames, whereas precise grounding calls for highresolution inputs. We tackle this trade-off with a two-system architecture: a Global Reasoning System selects informative keyframes and rewrites the task at low spatial cost, while a Detail Understanding System performs pixel-level grounding on the selected high-resolution snippets. Because "optimal" keyframe selection and reformulation are ambiguous and hard to supervise, we formulate them as a reinforcement-learning (RL) problem and present Omni-R1, an end-to-end RL framework built on Group Relative Policy Optimization. Omni-R1 trains the Global Reasoning System through hierarchical rewards obtained via online collaboration with the Detail Understanding System, requiring only one epoch of RL on small task splits. Experiments on two challenging benchmarks, Referring Audio-Visual Segmentation (RefAVS) and Reasoning Video Object Segmentation (REVOS), show that Omni-R1 not only surpasses strong supervised baselines but also outperforms specialized state-of-the-art models, while substantially improving out-of-domain generalization and mitigating multimodal hallucination. Our results demonstrate the first successful application of RL to large-scale omnimodal reasoning and highlight a scalable path toward universally foundation models.