We also acknowledge L. Trani for performing manual review and for valuable discussion on the project. The authors also thank the patients and their families for their selfless contribution to the advancement of science. Part of this work was performed as part of the Washington University School of Medicine Genomics Tumor Board, which was funded with private research support from the Division of Oncology and the McDonnell Genome Institute. E.K.B. was supported by the National Cancer Institute (T32GM007200 and U01CA209936). T.E.R. received support from the National Institutes of Health/National Cancer Institute (NIH/NCI) (R01CA142942) and the Breast Cancer Research Foundation.

NVIDIA has launched an open source project called Real-time Acceleration Platform for Integrated Data Science (RAPIDS) that aims to deliver end-to-end data science infrastructure based on GPUs. GPU-backed machines play an essential role in generating machine learning models. Data scientists run training jobs that are computationally intensive on GPUs. Massive datasets that are converted into complex matrices of numbers are used as an input for machine learning and deep learning models. During the training process, these matrices are added, multiplied and subtracted from other complex matrices.

You've probably heard that we're in the midst of an A.I. revolution. We're told that machine intelligence is progressing at an astounding rate, powered by "deep learning" algorithms that use huge amounts of data to train complicated programs knows as "neural networks." Today's A.I. programs can recognize faces and transcribe spoken sentences. We have programs that can spot subtle financial fraud, find relevant web pages in response to ambiguous queries, map the best driving route to almost any destination, beat human grandmasters at chess and Go, and translate between hundreds of languages. What's more, we've been promised that self-driving cars, automated cancer diagnoses, housecleaning robots and even automated scientific discovery are on the verge of becoming mainstream.

To date, the bulk of research on single-channel speech separation has been conducted using clean, near-field, read speech, which is not representative of many modern applications. In this work, we develop a procedure for constructing high-quality synthetic overlap datasets, necessary for most deep learning-based separation frameworks. We produced datasets that are more representative of realistic applications using the CHiME-5 and Mixer 6 corpora and evaluate standard methods on this data to demonstrate the shortcomings of current source-separation performance. We also demonstrate the value of a wide variety of data in training robust models that generalize well to multiple conditions.

In this paper, we introduce Deep Probabilistic Ensembles (DPEs), a scalable technique that uses a regularized ensemble to approximate a deep Bayesian Neural Network (BNN). We do so by incorporating a KL divergence penalty term into the training objective of an ensemble, derived from the evidence lower bound used in variational inference. We evaluate the uncertainty estimates obtained from our models for active learning on visual classification, consistently outperforming baselines and existing approaches.

Graphs are essential representations of many real-world data such as social networks. Recent years have witnessed the increasing efforts made to extend the neural network models to graph-structured data. These methods, which are usually known as the graph neural networks, have been applied to advance many graphs related tasks such as reasoning dynamics of the physical system, graph classification, and node classification. Most of the existing graph neural network models have been designed for static graphs, while many real-world graphs are inherently dynamic. For example, social networks are naturally evolving as new users joining and new relations being created. Current graph neural network models cannot utilize the dynamic information in dynamic graphs. However, the dynamic information has been proven to enhance the performance of many graph analytic tasks such as community detection and link prediction. Hence, it is necessary to design dedicated graph neural networks for dynamic graphs. In this paper, we propose DGNN, a new {\bf D}ynamic {\bf G}raph {\bf N}eural {\bf N}etwork model, which can model the dynamic information as the graph evolving. In particular, the proposed framework can keep updating node information by capturing the sequential information of edges (interactions), the time intervals between edges and information propagation coherently. Experimental results on various dynamic graphs demonstrate the effectiveness of the proposed framework.

In this paper, we propose an actor ensemble algorithm, named ACE, for continuous control with a deterministic policy in reinforcement learning. In ACE, we use actor ensemble (i.e., multiple actors) to search the global maxima of the critic. Besides the ensemble perspective, we also formulate ACE in the option framework by extending the option-critic architecture with deterministic intra-option policies, revealing a relationship between ensemble and options. Furthermore, we perform a look-ahead tree search with those actors and a learned value prediction model, resulting in a refined value estimation. We demonstrate a significant performance boost of ACE over DDPG and its variants in challenging physical robot simulators.

There is an arms race to defend neural networks against adversarial examples. Notably, adversarially robust training and verifiably robust training are the most promising defenses. The adversarially robust training scales well but cannot provide provable robustness guarantee for the absence of attacks. We present an Interval Attack that reveals fundamental problems about the threat model used by adversarially robust training. On the contrary, verifiably robust training achieves sound guarantee, but it is computationally expensive and sacrifices accuracy, which prevents it being applied in practice. In this paper, we propose two novel techniques for verifiably robust training, stochastic output approximation and dynamic mixed training, to solve the aforementioned challenges. They are based on two critical insights: (1) soundness is only needed in a subset of training data; and (2) verifiable robustness and test accuracy are conflicting to achieve after a certain point of verifiably robust training. On both MNIST and CIFAR datasets, we are able to achieve similar test accuracy and estimated robust accuracy against PGD attacks within $14\times$ less training time compared to state-of-the-art adversarially robust training techniques. In addition, we have up to 95.2% verified robust accuracy as a bonus. Also, to achieve similar verified robust accuracy, we are able to save up to $5\times$ computation time and offer 9.2% test accuracy improvement compared to current state-of-the-art verifiably robust training techniques.

Recent advances in deep learning have achieved impressive gains in classification accuracy on a variety of types of data, including images and text. Despite these gains, however, concerns have been raised about the interpretability of these models, as well as issues related to calibration and robustness. In this paper we propose a simple way to modify any conventional deep architecture to automatically provide more transparent explanations for classification decisions, as well as an intuitive notion of the credibility of each prediction. Specifically, we draw on ideas from nonparametric kernel regression, and propose to predict labels based on a weighted sum of training instances, where the weights are determined by distance in a learned instance-embedding space. Working within the framework of conformal methods, we propose a new measure of nonconformity suggested by our model, and experimentally validate the accompanying theoretical expectations, demonstrating improved transparency, controlled error rates, and robustness to out-of-domain data, without compromising on accuracy or calibration.

Recurrent neural networks (RNN) are at the core of modern automatic speech recognition (ASR) systems. In particular, long-short term memory (LSTM) recurrent neural networks have achieved state-of-the-art results in many speech recognition tasks, due to their efficient representation of long and short term dependencies in sequences of inter-dependent features. Nonetheless, internal dependencies within the element composing multidimensional features are weakly considered by traditional real-valued representations. We propose a novel quaternion long-short term memory (QLSTM) recurrent neural network that takes into account both the external relations between the features composing a sequence, and these internal latent structural dependencies with the quaternion algebra. QLSTMs are compared to LSTMs during a memory copy-task and a realistic application of speech recognition on the Wall Street Journal (WSJ) dataset. QLSTM reaches better performances during the two experiments with up to $2.8$ times less learning parameters, leading to a more expressive representation of the information.