Predicting the risk of potential diseases from Electronic Health Records (EHR) has attracted considerable attention in recent years, especially with the development of deep learning techniques. Compared with traditional machine learning models, deep learning based approaches achieve superior performance on risk prediction task. However, none of existing work explicitly takes prior medical knowledge (such as the relationships between diseases and corresponding risk factors) into account. In medical domain, knowledge is usually represented by discrete and arbitrary rules. Thus, how to integrate such medical rules into existing risk prediction models to improve the performance is a challenge.

One of the most crucial tasks in seismic reflection imaging is to identify the salt bodies with high precision. Traditionally, this is accomplished by visually picking the salt/sediment boundaries, which requires a great amount of manual work and may introduce systematic bias. With recent progress of deep learning algorithm and growing computational power, a great deal of efforts have been made to replace human effort with machine power in salt body interpretation. Currently, the method of Convolutional neural networks (CNN) is revolutionizing the computer vision field and has been a hot topic in the image analysis. In this paper, the benefits of CNN-based classification are demonstrated by using a state-of-art network structure U-Net, along with the residual learning framework ResNet, to delineate salt body with high precision. Network adjustments, including the Exponential Linear Units (ELU) activation function, the Lov\'{a}sz-Softmax loss function, and stratified $K$-fold cross-validation, have been deployed to further improve the prediction accuracy. The preliminary result using SEG Advanced Modeling (SEAM) data shows good agreement between the predicted salt body and manually interpreted salt body, especially in areas with weak reflections. This indicates the great potential of applying CNN for salt-related interpretations.

Generating novel molecules with optimal properties is a crucial step in many industries such as drug discovery. Recently, deep generative models have shown a promising way of performing de-novo molecular design. Although graph generative models are currently available they either have a graph size dependency in their number of parameters, limiting their use to only very small graphs or are formulated as a sequence of discrete actions needed to construct a graph, making the output graph non-differentiable w.r.t the model parameters, therefore preventing them to be used in scenarios such as conditional graph generation. In this work we propose a model for conditional graph generation that is computationally efficient and enables direct optimisation of the graph. We demonstrate favourable performance of our model on prototype-based molecular graph conditional generation tasks.

This project demonstrated a methodology to estimating cooperate credibility with a Natural Language Processing approach. As cooperate transparency impacts both the credibility and possible future earnings of the firm, it is an important factor to be considered by banks and investors on risk assessments of listed firms. This approach of estimating cooperate credibility can bypass human bias and inconsistency in the risk assessment, the use of large quantitative data and neural network models provides more accurate estimation in a more efficient manner compare to manual assessment. At the beginning, the model will employs Latent Dirichlet Allocation and THU Open Chinese Lexicon from Tsinghua University to classify topics in articles which are potentially related to corporate credibility. Then with the keywords related to each topics, we trained a residual convolutional neural network with data labeled according to surveys of fund manager and accountant's opinion on corporate credibility. After the training, we run the model with preprocessed news reports regarding to all of the 3065 listed companies, the model is supposed to give back companies ranking based on the level of their transparency.

Recent character and phoneme-based parametric TTS systems using deep learning have shown strong performance in natural speech generation. However, the choice between character or phoneme input can create serious limitations for practical deployment, as direct control of pronunciation is crucial in certain cases. We demonstrate a simple method for combining multiple types of linguistic information in a single encoder, named representation mixing, enabling flexible choice between character, phoneme, or mixed representations during inference. Experiments and user studies on a public audiobook corpus show the efficacy of our approach.

In this paper we are interested in the prediction of preterm birth based on diagnosis codes from longitudinal EHR. We formulate the prediction problem as a supervised classification with noisy labels. Our base classifier is a Recurrent Neural Network with an attention mechanism. We assume the availability of a data subset with both noisy and clean labels. For the cohort definition, most of the diagnosis codes on mothers' records related to pregnancy are ambiguous for the definition of full-term and preterm classes. On the other hand, diagnosis codes on babies' records provide fine-grained information on prematurity. Due to data de-identification, the links between mothers and babies are not available. We developed a heuristic based on admission and discharge times to match babies to their mothers and hence enrich mothers' records with additional information on delivery status. The obtained additional dataset from the matching heuristic has noisy labels and was used to leverage the training of the deep learning model. We propose an Alternating Loss Correction (ALC) method to train deep models with both clean and noisy labels. First, the label corruption matrix is estimated using the data subset with both noisy and clean labels. Then it is used in the model as a dense output layer to correct for the label noise. The network is alternately trained on epochs with the clean dataset with a simple cross-entropy loss and on next epoch with the noisy dataset and a loss corrected with the estimated corruption matrix. The experiments for the prediction of preterm birth at 90 days before delivery showed an improvement in performance compared with baseline and state of-the-art methods.

Recurrent neural networks (RNNs) such as long short-term memory and gated recurrent units are pivotal building blocks across a broad spectrum of sequence modeling problems. This paper proposes a recurrently controlled recurrent network (RCRN) for expressive and powerful sequence encoding. More concretely, the key idea behind our approach is to learn the recurrent gating functions using recurrent networks. Our architecture is split into two components - a controller cell and a listener cell whereby the recurrent controller actively influences the compositionality of the listener cell. We conduct extensive experiments on a myriad of tasks in the NLP domain such as sentiment analysis (SST, IMDb, Amazon reviews, etc.), question classification (TREC), entailment classification (SNLI, SciTail), answer selection (WikiQA, TrecQA) and reading comprehension (NarrativeQA). Across all 26 datasets, our results demonstrate that RCRN not only consistently outperforms BiLSTMs but also stacked BiLSTMs, suggesting that our controller architecture might be a suitable replacement for the widely adopted stacked architecture.

We construct a complexity-based morphospace to study systems-level properties of conscious & intelligent systems. The axes of this space label 3 complexity types: autonomous, cognitive & social. Given recent proposals to synthesize consciousness, a generic complexity-based conceptualization provides a useful framework for identifying defining features of conscious & synthetic systems. Based on current clinical scales of consciousness that measure cognitive awareness and wakefulness, we take a perspective on how contemporary artificially intelligent machines & synthetically engineered life forms measure on these scales. It turns out that awareness & wakefulness can be associated to computational & autonomous complexity respectively. Subsequently, building on insights from cognitive robotics, we examine the function that consciousness serves, & argue the role of consciousness as an evolutionary game-theoretic strategy. This makes the case for a third type of complexity for describing consciousness: social complexity. Having identified these complexity types, allows for a representation of both, biological & synthetic systems in a common morphospace. A consequence of this classification is a taxonomy of possible conscious machines. We identify four types of consciousness, based on embodiment: (i) biological consciousness, (ii) synthetic consciousness, (iii) group consciousness (resulting from group interactions), & (iv) simulated consciousness (embodied by virtual agents within a simulated reality). This taxonomy helps in the investigation of comparative signatures of consciousness across domains, in order to highlight design principles necessary to engineer conscious machines. This is particularly relevant in the light of recent developments at the crossroads of cognitive neuroscience, biomedical engineering, artificial intelligence & biomimetics.

An important field in robotics is the optimization of controllers. Currently, robots are often treated as a black box in this optimization process, which is the reason why derivative-free optimization methods such as evolutionary algorithms or reinforcement learning are omnipresent. When gradient-based methods are used, models are kept small or rely on finite difference approximations for the Jacobian. This method quickly grows expensive with increasing numbers of parameters, such as found in deep learning. We propose the implementation of a modern physics engine, which can differentiate control parameters. This engine is implemented for both CPU and GPU. Firstly, this paper shows how such an engine speeds up the optimization process, even for small problems. Furthermore, it explains why this is an alternative approach to deep Q-learning, for using deep learning in robotics. Finally, we argue that this is a big step for deep learning in robotics, as it opens up new possibilities to optimize robots, both in hardware and software.

Cryptocurrencies have come a long way since Bitcoin was first announced in late 2008. In just a decade the market has skyrocketed from zero to an estimated $400bn, and a further 3,000 cryptocurrencies have since launched. But this success has not been without its ups and downs. Bitcoin alone has fluctuated from almost $20,000 to less than a cent during this time. There's a lot of money to be made in cryptocurrency, and a lot of money to be lost.