Background: Pharmacokinetic evaluation is one of the key processes in drug discovery and development. However, current absorption, distribution, metabolism, excretion prediction models still have limited accuracy. Aim: This study aims to construct an integrated transfer learning and multitask learning approach for developing quantitative structure-activity relationship models to predict four human pharmacokinetic parameters. Methods: A pharmacokinetic dataset included 1104 U.S. FDA approved small molecule drugs. The dataset included four human pharmacokinetic parameter subsets (oral bioavailability, plasma protein binding rate, apparent volume of distribution at steady-state and elimination half-life). The pre-trained model was trained on over 30 million bioactivity data. An integrated transfer learning and multitask learning approach was established to enhance the model generalization. Results: The pharmacokinetic dataset was split into three parts (60:20:20) for training, validation and test by the improved Maximum Dissimilarity algorithm with the representative initial set selection algorithm and the weighted distance function. The multitask learning techniques enhanced the model predictive ability. The integrated transfer learning and multitask learning model demonstrated the best accuracies, because deep neural networks have the general feature extraction ability, transfer learning and multitask learning improved the model generalization. Conclusions: The integrated transfer learning and multitask learning approach with the improved dataset splitting algorithm was firstly introduced to predict the pharmacokinetic parameters. This method can be further employed in drug discovery and development.

Emotional content is a crucial ingredient in user-generated videos. However, the sparsely expressed emotions in the user-generated video cause difficulties to emotions analysis in videos. In this paper, we propose a new neural approach---Bi-stream Emotion Attribution-Classification Network (BEAC-Net) to solve three related emotion analysis tasks: emotion recognition, emotion attribution and emotion-oriented summarization, in an integrated framework. BEAC-Net has two major constituents, an attribution network and a classification network. The attribution network extracts the main emotional segment that classification should focus on in order to mitigate the sparsity problem. The classification network utilizes both the extracted segment and the original video in a bi-stream architecture. We contribute a new dataset for the emotion attribution task with human-annotated ground-truth labels for emotion segments. Experiments on two video datasets demonstrate superior performance of the proposed framework and the complementary nature of the dual classification streams.

Unconditional image generation has recently been dominated by generative adversarial networks (GANs). GAN methods train a generator which regresses images from random noise vectors, as well as a discriminator that attempts to differentiate between the generated images and a training set of real images. GANs have shown amazing results at generating realistic looking images. Despite their success, GANs suffer from critical drawbacks including: unstable training and mode-dropping. The weaknesses in GANs have motivated research into alternatives including: variational auto-encoders (VAEs), latent embedding learning methods (e.g. GLO) and nearest-neighbor based implicit maximum likelihood estimation (IMLE). Unfortunately at the moment, GANs still significantly outperform the alternative methods for image generation. In this work, we present a novel method - Generative Latent Nearest Neighbors (GLANN) - for training generative models without adversarial training. GLANN combines the strengths of IMLE and GLO in a way that overcomes the main drawbacks of each method. Consequently, GLANN generates images that are far better than GLO and IMLE. Our method does not suffer from mode collapse which plagues GAN training and is much more stable. Qualitative results show that GLANN outperforms a baseline consisting of 800 GANs and VAEs on commonly used datasets. Our models are also shown to be effective for training truly non-adversarial unsupervised image translation.

We study the phenomenon of bias amplification in classifiers, wherein a machine learning model learns to predict classes with a greater disparity than the underlying ground truth. We demonstrate that bias amplification can arise via an inductive bias in gradient descent methods that results in the overestimation of the importance of moderately-predictive "weak" features if insufficient training data is available. This overestimation gives rise to feature-wise bias amplification -- a previously unreported form of bias that can be traced back to the features of a trained model. Through analysis and experiments, we show that while some bias cannot be mitigated without sacrificing accuracy, feature-wise bias amplification can be mitigated through targeted feature selection. We present two new feature selection algorithms for mitigating bias amplification in linear models, and show how they can be adapted to convolutional neural networks efficiently. Our experiments on synthetic and real data demonstrate that these algorithms consistently lead to reduced bias without harming accuracy, in some cases eliminating predictive bias altogether while providing modest gains in accuracy.

This paper describes a Semantic Frame parsing System based on sequence labeling methods, precisely BiLSTM models with highway connections, for performing information extraction on a corpus of French encyclopedic history texts annotated according to the Berkeley FrameNet formalism. The approach proposed in this study relies on an integrated sequence labeling model which jointly optimizes frame identification and semantic role segmentation and identification. The purpose of this study is to analyze the task complexity, to highlight the factors that make Semantic Frame parsing a difficult task and to provide detailed evaluations of the performance on different types of frames and sentences.

This paper describes the development of the Microsoft XiaoIce system, the most popular social chatbot in the world. XiaoIce is uniquely designed as an AI companion with an emotional connection to satisfy the human need for communication, affection, and social belonging. We take into account both intelligent quotient (IQ) and emotional quotient (EQ) in system design, cast human-machine social chat as decision-making over Markov Decision Processes (MDPs), and optimize XiaoIce for long-term user engagement, measured in expected Conversation-turns Per Session (CPS). We detail the system architecture and key components including dialogue manager, core chat, skills, and an empathetic computing module. We show how XiaoIce dynamically recognizes human feelings and states, understands user intents, and responds to user needs throughout long conversations. Since the release in 2014, XiaoIce has communicated with over 660 million users and succeeded in establishing long-term relationships with many of them. Analysis of large-scale online logs shows that XiaoIce has achieved an average CPS of 23, which is significantly higher than that of other chatbots and even human conversations.

The wide spread use of online recruitment services has led to information explosion in the job market. As a result, the recruiters have to seek the intelligent ways for Person Job Fit, which is the bridge for adapting the right job seekers to the right positions. Existing studies on Person Job Fit have a focus on measuring the matching degree between the talent qualification and the job requirements mainly based on the manual inspection of human resource experts despite of the subjective, incomplete, and inefficient nature of the human judgement. To this end, in this paper, we propose a novel end to end Ability aware Person Job Fit Neural Network model, which has a goal of reducing the dependence on manual labour and can provide better interpretation about the fitting results. The key idea is to exploit the rich information available at abundant historical job application data. Specifically, we propose a word level semantic representation for both job requirements and job seekers' experiences based on Recurrent Neural Network. Along this line, four hierarchical ability aware attention strategies are designed to measure the different importance of job requirements for semantic representation, as well as measuring the different contribution of each job experience to a specific ability requirement. Finally, extensive experiments on a large scale real world data set clearly validate the effectiveness and interpretability of the APJFNN framework compared with several baselines.

It would be impractical to count the number of solar panels in the US by hand, and that makes it difficult to gauge just how far the technology has really spread. Stanford researchers have a solution: make AI do the heavy lifting. They've crafted a deep learning system, DeepSolar, that mapped every visible solar panel in the US -- about 1.47 million of them, if you're wondering. The neural network-based approach turns satellite imagery into tiles, classifies every pixel within those tiles, and combines those pixels to determine if there are solar panels in a given area, whether they're large solar farms or individual rooftop installations. This method is accurate, requires only basic oversight and (most importantly) fast.

An equivalent approach might be to use a smaller subset of the training dataset without regularization to allow faster training and some overfitting. The desire for slightly under-optimized models applies to the selection of ensemble members more generally.

Right now, I can open up Google Photos, type "beach," and see my photos from various beaches I've visited over the last decade. I never went through my photos and labeled them; instead, Google identifies beaches based on the contents of the photos themselves. This seemingly mundane feature is based on a technology called deep convolutional neural networks, which allows software to understand images in a sophisticated way that wasn't possible with prior techniques. In recent years, researchers have found that the accuracy of the software gets better and better as they build deeper networks and amass larger data sets to train them. That has created an almost insatiable appetite for computing power, boosting the fortunes of GPU makers like Nvidia and AMD.