Representation learning (RL) plays an important role in extracting proper representations from complex medical data for various analyzing tasks, such as patient grouping, clinical endpoint prediction and medication recommendation. Medical data can be divided into two typical categories, outpatient and inpatient, that have different data characteristics. However, few of existing RL methods are specially designed for inpatients data, which have strong temporal relations and consistent diagnosis. In addition, for unordered medical activity set, existing medical RL methods utilize a simple pooling strategy, which would result in indistinguishable contributions among the activities for learning. In this work, weproposeInpatient2Vec, anovelmodel for learning three kinds of representations for inpatient, including medical activity, hospital day and diagnosis. A multi-layer self-attention mechanism with two training tasks is designed to capture the inpatient data characteristics and process the unordered set. Using a real-world dataset, we demonstrate that the proposed approach outperforms the competitive baselines on semantic similarity measurement and clinical events prediction tasks.

The task of predicting future stock values has always been one that is heavily desired albeit very difficult. This difficulty arises from stocks with non-stationary behavior, and without any explicit form. Hence, predictions are best made through analysis of financial stock data. To handle big data sets, current convention involves the use of the Moving Average. However, by utilizing the Wavelet Transform in place of the Moving Average to denoise stock signals, financial data can be smoothened and more accurately broken down. This newly transformed, denoised, and more stable stock data can be followed up by non-parametric statistical methods, such as Support Vector Regression (SVR) and Recurrent Neural Network (RNN) based Long Short-Term Memory (LSTM) networks to predict future stock prices. Through the implementation of these methods, one is left with a more accurate stock forecast, and in turn, increased profits.

Accurate prediction of drug-target interaction (DTI) is essential for in silico drug design. For the purpose, we propose a novel approach for predicting DTI using a GNN that directly incorporates the 3D structure of a protein-ligand complex. We also apply a distance-aware graph attention algorithm with gate augmentation to increase the performance of our model. As a result, our model shows better performance than docking and other deep learning methods for both virtual screening and pose prediction. In addition, our model can reproduce the natural population distribution of active molecules and inactive molecules.

We develop ensemble Convolutional Neural Networks (CNNs) to classify the transportation mode of trip data collected as part of a large-scale smartphone travel survey in Montreal, Canada. Our proposed ensemble library is composed of a series of CNN models with different hyper-parameter values and CNN architectures. In our final model, we combine the output of CNN models using "average voting", "majority voting" and "optimal weights" methods. Furthermore, we exploit the ensemble library by deploying a Random Forest model as a meta-learner. The ensemble method with random forest as meta-learner shows an accuracy of 91.8% which surpasses the other three ensemble combination methods, as well as other comparable models reported in the literature. The "majority voting" and "optimal weights" combination methods result in prediction accuracy rates around 89%, while "average voting" is able to achieve an accuracy of only 85%.

Computational models that forecast the progression of Alzheimer's disease at the patient level are extremely useful tools for identifying high risk cohorts for early intervention and treatment planning. The state-of-the-art work in this area proposes models that forecast by using latent representations extracted from the longitudinal data across multiple modalities, including volumetric information extracted from medical scans and demographic info. These models incorporate the time horizon, which is the amount of time between the last recorded visit and the future visit, by directly concatenating a representation of it to the data latent representation. In this paper, we present a model which generates a sequence of latent representations of the patient status across the time horizon, providing more informative modeling of the temporal relationships between the patient's history and future visits. Our proposed model outperforms the baseline in terms of forecasting accuracy and F1 score with the added benefit of robustly handling mis sing visits.

This article reports on an investigation of the use of convolutional neural networks to predict the visual attention of chess players. The visual attention model described in this article has been created to generate saliency maps that capture hierarchical and spatial features of chessboard, in order to predict the probability fixation for individual pixels Using a skip-layer architecture of an autoencoder, with a unified decoder, we are able to use multiscale features to predict saliency of part of the board at different scales, showing multiple relations between pieces. We have used scan path and fixation data from players engaged in solving chess problems, to compute 6600 saliency maps associated to the corresponding chess piece configurations. This corpus is completed with synthetically generated data from actual games gathered from an online chess platform. Experiments realized using both scan-paths from chess players and the CAT2000 saliency dataset of natural images, highlights several results. Deep features, pretrained on natural images, were found to be helpful in training visual attention prediction for chess. The proposed neural network architecture is able to generate meaningful saliency maps on unseen chess configurations with good scores on standard metrics. This work provides a baseline for future work on visual attention prediction in similar contexts.

Deep neural networks are vulnerable to adversarial attacks. Numerous efforts have focused on defenses that either try to patch `holes' in trained models or try to make it difficult or costly to compute adversarial examples exploiting these holes. In our work, we explore a counter-intuitive approach of constructing "adversarial trapdoors. Unlike prior works that try to patch or disguise vulnerable points in the manifold, we intentionally inject `trapdoors,' artificial weaknesses in the manifold that attract optimized perturbation into certain pre-embedded local optima. As a result, the adversarial generation functions naturally gravitate towards our trapdoors, producing adversarial examples that the model owner can recognize through a known neuron activation signature. In this paper, we introduce trapdoors and describe an implementation of trapdoors using similar strategies to backdoor/Trojan attacks. We show that by proactively injecting trapdoors into the models (and extracting their neuron activation signature), we can detect adversarial examples generated by the state of the art attacks (Projected Gradient Descent, Optimization based CW, and Elastic Net) with high detection success rate and negligible impact on normal inputs. These results also generalize across multiple classification domains (image recognition, face recognition and traffic sign recognition). We explore different properties of trapdoors, and discuss potential countermeasures (adaptive attacks) and mitigations.

Social network analysis is an important problem in data mining. A fundamental step for analyzing social networks is to encode network data into low-dimensional representations, i.e., network embeddings, so that the network topology structure and other attribute information can be effectively preserved. Network representation leaning facilitates further applications such as classification, link prediction, anomaly detection and clustering. In addition, techniques based on deep neural networks have attracted great interests over the past a few years. In this survey, we conduct a comprehensive review of current literature in network representation learning utilizing neural network models. First, we introduce the basic models for learning node representations in homogeneous networks. Meanwhile, we will also introduce some extensions of the base models in tackling more complex scenarios, such as analyzing attributed networks, heterogeneous networks and dynamic networks. Then, we introduce the techniques for embedding subgraphs. After that, we present the applications of network representation learning. At the end, we discuss some promising research directions for future work.

We present a probabilistic model for Sketch-Based Image Retrieval (SBIR) where, at retrieval time, we are given sketches from novel classes, that were not present at training time. Existing SBIR methods, most of which rely on learning class-wise correspondences between sketches and images, typically work well only for previously seen sketch classes, and result in poor retrieval performance on novel classes. To address this, we propose a generative model that learns to generate images, conditioned on a given novel class sketch. This enables us to reduce the SBIR problem to a standard image-to-image search problem. Our model is based on an inverse auto-regressive flow based variational autoencoder, with a feedback mechanism to ensure robust image generation. We evaluate our model on two very challenging datasets, Sketchy, and TU Berlin, with novel train-test split. The proposed approach significantly outperforms various baselines on both the datasets.

Neural Network classifiers have been used successfully in a wide range of applications. However, their underlying assumption of attack free environment has been defied by adversarial examples. Researchers tried to develop defenses; however, existing approaches are still far from providing effective solutions to this evolving problem. In this paper, we design a generative adversarial net (GAN) based zero knowledge adversarial training defense, dubbed ZK-GanDef, which does not consume adversarial examples during training. Therefore, ZK-GanDef is not only efficient in training but also adaptive to new adversarial examples. This advantage comes at the cost of small degradation in test accuracy compared to full knowledge approaches. Our experiments show that ZK-GanDef enhances test accuracy on adversarial examples by up-to 49.17% compared to zero knowledge approaches. More importantly, its test accuracy is close to that of the state-of-the-art full knowledge approaches (maximum degradation of 8.46%), while taking much less training time.