We train an enhanced deep convolutional neural network in order to identify eight cardiac abnormalities from the standard 12-lead electrocardiograms (ECGs) using the dataset of 14000 ECGs. Instead of straightforwardly applying an end-to-end deep learning approach, we find that deep convolutional neural networks enhanced with sophisticated hand crafted features show advantages in reducing generalization errors. Additionally, data preprocessing and augmentation are essential since the distribution of eight cardiac abnormalities are highly biased in the given dataset. Our approach achieves promising generalization performance in the First China ECG Intelligent Competition; an empirical evaluation is also provided to validate the efficacy of our design on the competition ECG dataset. Keywords: Electrocardiogram · Deep Convolutional Neural Network · Heart Disease Diagnosis. 1 Introduction The electrocardiogram (ECG) is a diagnostic tool widely utilized for noninvasive diagnosis of various cardiovascular abnormalities in practice of clinical medicine worldwide. For example, there are approximately 250 million ECG recordings being processed by technicians for the diagnosis and treatment of patients with cardiovascular disease in China. The standard 12-lead electrocardiograms are the records of the heart's electrical activity collected from electrodes on arms/legs (known as limb leads) and torso (known as precordial leads). ECG interpretation plays an central role in the assessment of cardiovascular disease based on either a cardiologist's experience or computer-aided diagnosis systems. In practice, compute-aided interpretation has become increasingly important, since such technique improves the accuracy of diagnosis, facilitates health care decision making and reduces costs [17].

Predicting drug-target interactions (DTI) is an essential part of the drug discovery process, which is an expensive process in terms of time and cost. Therefore, reducing DTI cost could lead to reduced healthcare costs for a patient. In addition, a precisely learned molecule representation in a DTI model could contribute to developing personalized medicine, which will help many patient cohorts. In this paper, we propose a new molecule representation based on the self-attention mechanism, and a new DTI model using our molecule representation. The experiments show that our DTI model outperforms the state of the art by up to 4.9% points in terms of area under the precision-recall curve. Moreover, a study using the DrugBank database proves that our model effectively lists all known drugs targeting a specific cancer biomarker in the top-30 candidate list.

Multimodal language analysis is an emerging research area in natural language processing that models language in a multimodal manner. It aims to understand language from the modalities of text, visual, and acoustic by modeling both intra-modal and cross-modal interactions. BERT (Bidirectional Encoder Representations from Transformers) provides strong contextual language representations after training on large-scale unlabeled corpora. Fine-tuning the vanilla BERT model has shown promising results in building state-of-the-art models for diverse NLP tasks like question answering and language inference. However, fine-tuning BERT in the presence of information from other modalities remains an open research problem. In this paper, we inject multimodal information within the input space of BERT network for modeling multimodal language. The proposed injection method allows BERT to reach a new state of the art of $84.38\%$ binary accuracy on CMU-MOSI dataset (multimodal sentiment analysis) with a gap of 5.98 percent to the previous state of the art and 1.02 percent to the text-only BERT.

PREPRINT 1 MimickNet, Matching Clinical Post-Processing Under Realistic Black-Box Constraints Ouwen Huang, Student Member, IEEE, Will Long, Student Member, IEEE, Nick Bottenus, Gregg E. Trahey, Senior Member, IEEE, Sina Farsiu, Senior Member, IEEE, and Mark L. Palmeri, Senior Member, IEEE Abstract --Image post-processing is used in clinical-grade ultrasound scanners to improve image quality (e.g., reduce speckle noise and enhance contrast). These post-processing techniques vary across manufacturers and are generally kept proprietary, which presents a challenge for researchers looking to match current clinical-grade workflows. We introduce a deep learning framework, MimickNet, that transforms raw conventional delay-and-summed (DAS) beams into the approximate post-processed images found on clinical-grade scanners. Training MimickNet only requires post-processed image samples from a scanner of interest without the need for explicit pairing to raw DAS data. This flexibility allows it to hypothetically approximate any manufacturer's post-processing without access to the pre-processed data. MimickNet generates images with an average similarity index measurement (SSIM) of 0.930 0.0892 on a 300 cineloop test set, and it generalizes to cardiac cineloops outside of our train-test distribution achieving an SSIM of 0.967 0.002. We also explore the theoretical SSIM achievable by evaluating MimickNet performance when trained under gray-box constraints (i.e., when both pre-processed and post-processed images are available). T o our knowledge, this is the first work to establish deep learning models that closely approximate current clinical-grade ultrasound post-processing under realistic black-box constraints where before and after post-processing data is unavailable. MimickNet serves as a clinical post-processing baseline for future works in ultrasound image formation to compare against.

Automatic segmentation methods based on deep learning have recently demonstrated state-of-the-art performance, outperforming the ordinary methods. Nevertheless, these methods are inapplicable for small datasets, which are very common in medical problems. To this end, we propose a knowledge transfer method between diseases via the Generative Bayesian Prior network. Our approach is compared to a pre-train approach and random initialization and obtains the best results in terms of Dice Similarity Coefficient metric for the small subsets of the Brain Tumor Segmentation 2018 database (BRATS2018).

Recently, a variety of regularization techniques have been widely applied in deep neural networks, such as dropout, batch normalization, data augmentation, and so on. These methods mainly focus on the regularization of weight parameters to prevent overfitting effectively. In addition, label regularization techniques such as label smoothing and label disturbance have also been proposed with the motivation of adding a stochastic perturbation to labels. In this paper, we propose a novel adaptive label regularization method, which enables the neural network to learn from the erroneous experience and update the optimal label representation online. On the other hand, compared with knowledge distillation, which learns the correlation of categories using teacher network, our proposed method requires only a minuscule increase in parameters without cumbersome teacher network. Furthermore, we evaluate our method on CIFAR-10/CIFAR-100/ImageNet datasets for image recognition tasks and AGNews/Yahoo/Yelp-Full datasets for text classification tasks. The empirical results show significant improvement under all experimental settings.

An agent that has well understood the environment should be able to apply its skills for any given goals, leading to the fundamental problem of learning the Universal Value Function Approximator (UVFA). A UVFA learns to predict the cumulative rewards between all state-goal pairs. However, empirically, the value function for long-range goals is always hard to estimate and may consequently result in failed policy. This has presented challenges to the learning process and the capability of neural networks. We propose a method to address this issue in large MDPs with sparse rewards, in which exploration and routing across remote states are both extremely challenging. Our method explicitly models the environment in a hierarchical manner, with a high-level dynamic landmark-based map abstracting the visited state space, and a low-level value network to derive precise local decisions. We use farthest point sampling to select landmark states from past experience, which has improved exploration compared with simple uniform sampling. Experimentally we showed that our method enables the agent to reach long-range goals at the early training stage, and achieve better performance than standard RL algorithms for a number of challenging tasks.

The collaborative ranking problem has been an important open research question as most recommendation problems can be naturally formulated as ranking problems. While much of collaborative ranking methodology assumes static ranking data, the importance of temporal information to improving ranking performance is increasingly apparent. Recent advances in deep learning, especially the discovery of various attention mechanisms and newer architectures in addition to widely used RNN and CNN in natural language processing, have allowed us to make better use of the temporal ordering of items that each user has engaged with. In particular, the SASRec model, inspired by the popular Transformer model in natural languages processing, has achieved state-of-art results in the temporal collaborative ranking problem and enjoyed more than 10x speed-up when compared to earlier CNN/RNN-based methods. However, SASRec is inherently an un-personalized model and does not include personalized user embeddings. To overcome this limitation, we propose a Personalized Transformer (SSE-PT) model, outperforming SASRec by almost 5% in terms of NDCG@10 on 5 real-world datasets. Furthermore, after examining some random users' engagement history and corresponding attention heat maps used during the inference stage, we find our model is not only more interpretable but also able to focus on recent engagement patterns for each user. Moreover, our SSE-PT model with a slight modification, which we call SSE-PT++, can handle extremely long sequences and outperform SASRec in ranking results with comparable training speed, striking a balance between performance and speed requirements. Code and data are open sourced at https://github.com/wuliwei9278/SSE-PT.

Sex trafficking is a global epidemic. Escort websites are a primary vehicle for selling the services of such trafficking victims and thus a major driver of trafficker revenue. Many law enforcement agencies do not have the resources to manually identify leads from the millions of escort ads posted across dozens of public websites. We propose an ordinal regression neural network to identify escort ads that are likely linked to sex trafficking. Our model uses a modified cost function to mitigate inconsistencies in predictions often associated with nonparametric ordinal regression and leverages recent advancements in deep learning to improve prediction accuracy. The proposed method significantly improves on the previous state-of-the-art on Trafficking-10K, an expert-annotated dataset of escort ads. Additionally, because traffickers use acronyms, deliberate typographical errors, and emojis to replace explicit keywords, we demonstrate how to expand the lexicon of trafficking flags through word embeddings and t-SNE.

Network alignment is a critical task to a wide variety of fields. Many existing works leverage on representation learning to accomplish this task without eliminating domain representation bias induced by domain-dependent features, which yield inferior alignment performance. This paper proposes a unified deep architecture (DANA) to obtain a domain-invariant representation for network alignment via an adversarial domain classifier. Specifically, we employ the graph convolutional networks to perform network embedding under the domain adversarial principle, given a small set of observed anchors. Then, the semi-supervised learning framework is optimized by maximizing a posterior probability distribution of observed anchors and the loss of a domain classifier simultaneously. We also develop a few variants of our model, such as, direction-aware network alignment, weight-sharing for directed networks and simplification of parameter space. Experiments on three real-world social network datasets demonstrate that our proposed approaches achieve state-of-the-art alignment results.