Fairness and accountability are two essential pillars for trustworthy Artificial Intelligence (AI) in healthcare. However, the existing AI model may be biased in its decision marking. To tackle this issue, we propose an adversarial multi-task training strategy to simultaneously mitigate and detect bias in the deep learning-based medical image analysis system. Specifically, we propose to add a discrimination module against bias and a critical module that predicts unfairness within the base classification model. We further impose an orthogonality regularization to force the two modules to be independent during training. Hence, we can keep these deep learning tasks distinct from one another, and avoid collapsing them into a singular point on the manifold. Through this adversarial training method, the data from the underprivileged group, which is vulnerable to bias because of attributes such as sex and skin tone, are transferred into a domain that is neutral relative to these attributes. Furthermore, the critical module can predict fairness scores for the data with unknown sensitive attributes. We evaluate our framework on a large-scale public-available skin lesion dataset under various fairness evaluation metrics. The experiments demonstrate the effectiveness of our proposed method for estimating and improving fairness in the deep learning-based medical image analysis system.

We study low-rank parameterizations of weight matrices with embedded spectral properties in the Deep Learning context. The low-rank property leads to parameter efficiency and permits taking computational shortcuts when computing mappings. Spectral properties are often subject to constraints in optimization problems, leading to better models and stability of optimization. We start by looking at the compact SVD parameterization of weight matrices and identifying redundancy sources in the parameterization. We further apply the Tensor Train (TT) decomposition to the compact SVD components, and propose a non-redundant differentiable parameterization of fixed TT-rank tensor manifolds, termed the Spectral Tensor Train Parameterization (STTP). We demonstrate the effects of neural network compression in the image classification setting and both compression and improved training stability in the generative adversarial training setting.

We present a continual learning approach for generative adversarial networks (GANs), by designing and leveraging parameter-efficient feature map transformations. Our approach is based on learning a set of global and task-specific parameters. The global parameters are fixed across tasks whereas the task specific parameters act as local adapters for each task, and help in efficiently transforming the previous task's feature map to the new task's feature map. Moreover, we propose an element-wise residual bias in the transformed feature space which highly stabilizes GAN training. In contrast to the recent approaches for continual GANs, we do not rely on memory replay, regularization towards previous tasks' parameters, or expensive weight transformations. Through extensive experiments on challenging and diverse datasets, we show that the feature-map transformation based approach outperforms state-of-the-art continual GANs methods, with substantially fewer parameters, and also generates high-quality samples that can be used in generative replay based continual learning of discriminative tasks.

This work proposes a semi-parametric approach to estimate Covid-19 (SARS-CoV-2) evolution in Spain. Considering the sequences of 14 days cumulative incidence of all Spanish regions, it combines modern Deep Learning (DL) techniques for analyzing sequences with the usual Bayesian Poisson-Gamma model for counts. DL model provides a suitable description of observed sequences but no reliable uncertainty quantification around it can be obtained. To overcome this we use the prediction from DL as an expert elicitation of the expected number of counts along with their uncertainty and thus obtaining the posterior predictive distribution of counts in an orthodox Bayesian analysis using the well known Poisson-Gamma model. The overall resulting model allows us to either predict the future evolution of the sequences on all regions, as well as, estimating the consequences of eventual scenarios.

Video deblurring models exploit consecutive frames to remove blurs from camera shakes and object motions. In order to utilize neighboring sharp patches, typical methods rely mainly on homography or optical flows to spatially align neighboring blurry frames. However, such explicit approaches are less effective in the presence of fast motions with large pixel displacements. In this work, we propose a novel implicit method to learn spatial correspondence among blurry frames in the feature space. To construct distant pixel correspondences, our model builds a correlation volume pyramid among all the pixel-pairs between neighboring frames. To enhance the features of the reference frame, we design a correlative aggregation module that maximizes the pixel-pair correlations with its neighbors based on the volume pyramid. Finally, we feed the aggregated features into a reconstruction module to obtain the restored frame. We design a generative adversarial paradigm to optimize the model progressively. Our proposed method is evaluated on the widely-adopted DVD dataset, along with a newly collected High-Frame-Rate (1000 fps) Dataset for Video Deblurring (HFR-DVD). Quantitative and qualitative experiments show that our model performs favorably on both datasets against previous state-of-the-art methods, confirming the benefit of modeling all-range spatial correspondence for video deblurring.

A single gene can encode for different protein versions through a process called alternative splicing. Since proteins play major roles in cellular functions, aberrant splicing profiles can result in a variety of diseases, including cancers. Alternative splicing is determined by the gene's primary sequence and other regulatory factors such as RNA-binding protein levels. With these as input, we formulate the prediction of RNA splicing as a regression task and build a new training dataset (CAPD) to benchmark learned models. We propose discrete compositional energy network (DCEN) which leverages the hierarchical relationships between splice sites, junctions and transcripts to approach this task. In the case of alternative splicing prediction, DCEN models mRNA transcript probabilities through its constituent splice junctions' energy values. These transcript probabilities are subsequently mapped to relative abundance values of key nucleotides and trained with ground-truth experimental measurements. Through our experiments on CAPD, we show that DCEN outperforms baselines and ablation variants.

There has been a growing interest in model-agnostic methods that can make deep learning models more transparent and explainable to a user. Some researchers recently argued that for a machine to achieve a certain degree of human-level explainability, this machine needs to provide human causally understandable explanations, also known as causability. A specific class of algorithms that have the potential to provide causability are counterfactuals. This paper presents an in-depth systematic review of the diverse existing body of literature on counterfactuals and causability for explainable artificial intelligence. We performed an LDA topic modelling analysis under a PRISMA framework to find the most relevant literature articles. This analysis resulted in a novel taxonomy that considers the grounding theories of the surveyed algorithms, together with their underlying properties and applications in real-world data. This research suggests that current model-agnostic counterfactual algorithms for explainable AI are not grounded on a causal theoretical formalism and, consequently, cannot promote causability to a human decision-maker. Our findings suggest that the explanations derived from major algorithms in the literature provide spurious correlations rather than cause/effects relationships, leading to sub-optimal, erroneous or even biased explanations. This paper also advances the literature with new directions and challenges on promoting causability in model-agnostic approaches for explainable artificial intelligence.

We introduce the task of changing the narrative point of view, where characters are assigned a narrative perspective that is different from the one originally used by the writer. The resulting shift in the narrative point of view alters the reading experience and can be used as a tool in fiction writing or to generate types of text ranging from educational to self-help and self-diagnosis. We introduce a benchmark dataset containing a wide range of types of narratives annotated with changes in point of view from deictic (first or second person) to anaphoric (third person) and describe a pipeline for processing raw text that relies on a neural architecture for mention selection. Evaluations on the new benchmark dataset show that the proposed architecture substantially outperforms the baselines by generating mentions that are less ambiguous and more natural.

A video prediction model that generalizes to diverse scenes would enable intelligent agents such as robots to perform a variety of tasks via planning with the model. However, while existing video prediction models have produced promising results on small datasets, they suffer from severe underfitting when trained on large and diverse datasets. To address this underfitting challenge, we first observe that the ability to train larger video prediction models is often bottlenecked by the memory constraints of GPUs or TPUs. In parallel, deep hierarchical latent variable models can produce higher quality predictions by capturing the multi-level stochasticity of future observations, but end-to-end optimization of such models is notably difficult. Our key insight is that greedy and modular optimization of hierarchical autoencoders can simultaneously address both the memory constraints and the optimization challenges of large-scale video prediction. We introduce Greedy Hierarchical Variational Autoencoders (GHVAEs), a method that learns high-fidelity video predictions by greedily training each level of a hierarchical autoencoder. In comparison to state-of-the-art models, GHVAEs provide 17-55% gains in prediction performance on four video datasets, a 35-40% higher success rate on real robot tasks, and can improve performance monotonically by simply adding more modules.

Radiomic representations can quantify properties of regions of interest in medical image data. Classically, they account for pre-defined statistics of shape, texture, and other low-level image features. Alternatively, deep learning-based representations are derived from supervised learning but require expensive annotations from experts and often suffer from overfitting and data imbalance issues. In this work, we address the challenge of learning representations of 3D medical images for an effective quantification under data imbalance. We propose a \emph{self-supervised} representation learning framework to learn high-level features of 3D volumes as a complement to existing radiomics features. Specifically, we demonstrate how to learn image representations in a self-supervised fashion using a 3D Siamese network. More importantly, we deal with data imbalance by exploiting two unsupervised strategies: a) sample re-weighting, and b) balancing the composition of training batches. When combining our learned self-supervised feature with traditional radiomics, we show significant improvement in brain tumor classification and lung cancer staging tasks covering MRI and CT imaging modalities.