Playtesting is an essential step in the game design process. Game designers use the feedback from playtests to refine their design. Game designers may employ procedural personas to automate the playtesting process. In this paper, we present two approaches to improve automated playtesting. First, we propose a goal-based persona model, which we call developing persona -- developing persona proposes a dynamic persona model, whereas the current persona models are static. Game designers can use the developing persona to model the changes that a player undergoes while playing a game. Additionally, a human playtester knows which paths she has tested before, and during the consequent tests, she may test different paths. However, RL agents disregard the previously generated trajectories. We propose a novel methodology that helps Reinforcement Learning (RL) agents to generate distinct trajectories than the previous trajectories. We refer to this methodology as Alternative Path Finder (APF). We present a generic APF framework that can be applied to all RL agents. APF is trained with the previous trajectories, and APF distinguishes the novel states from similar states. We use the General Video Game Artificial Intelligence (GVG-AI) and VizDoom frameworks to test our proposed methodologies. We use Proximal Policy Optimization (PPO) RL agent during experiments. First, we show that the playtest data generated by the developing persona cannot be generated using the procedural personas. Second, we present the alternative paths found using APF. We show that the APF penalizes the previous paths and rewards the distinct paths.

Glaucoma is a leading cause of irreversible blindness worldwide. A recent global meta-analysis of 50 population-based studies reported the pooled glaucoma prevalence (age range, 40-80 years) to be 3.5%, corresponding to an estimated 64.3 million individuals worldwide. Li, Zhixi et al. used deep learning system to detect referable GON (glaucomatous optic neuropathy) with high sensitivity and specificity. The study recruited 21 trained ophthalmologists to classify the photographs. Referable GON was defined as vertical cup-to-disc ratio of 0.7 or more and other typical changes of GON.

The 3.0 version has state of the art transformer-based pipelines and pre-trained models in seventeen languages. The first version of spaCy was a preliminary version with little support for deep-learning workflows. The second version, however, introduced convoluted neural network models in seven different languages. The third version is a massive improvement over both of these versions. The 3.0 version has completed dropped support for Python 2 and only works on Python 3.6.

All the sessions from Transform 2021 are available on-demand now. As the IBM Watson experience shows, the path to AI success is fraught with challenges. Yet overall, it has been a very good year for AI and the companies developing it. So much so that Alphabet CEO Sundar Pichai, in a recent podcast recorded by BBC, says: "I view [AI] as a very profound enabling technology. If you think about fire or electricity or the internet, it is like that, but I think even more profound."

Technology and Technological developments in this decade have led to some of the most awe-inspiring discoveries. With rapidly changing technology and systems to support them and provide back-end processing power, the world seems to be becoming a better place to live day by day. Technology has reached such new heights that nothing our ingenious mind today thinks about looks impossible to accomplish. The driving factor of such advancements in this new era of technological and computational superiority seems to be wrapped around two of the most highly debated domains and topics, namely Machine Learning & Artificial Intelligence. The canvas and ideal space that these two domains provide are unfathomable.

Protein-ligand binding prediction has extensive biological significance. Binding affinity helps in understanding the degree of protein-ligand interactions and is a useful measure in drug design. Protein-ligand docking using virtual screening and molecular dynamic simulations are required to predict the binding affinity of a ligand to its cognate receptor. Performing such analyses to cover the entire chemical space of small molecules requires intense computational power. Recent developments using deep learning have enabled us to make sense of massive amounts of complex data sets where the ability of the model to "learn" intrinsic patterns in a complex plane of data is the strength of the approach.

In the nine years since AlexNet spawned the age of deep learning, artificial intelligence (AI) has made significant technological progress in medical imaging, with more than 80 deep-learning algorithms approved by the U.S. FDA since 2012 for clinical applications in image detection and measurement. A 2020 survey found that more than 82% of imaging providers believe AI will improve diagnostic imaging over the next 10 years and the market for AI in medical imaging is expected to grow 10-fold in the same period. Despite this optimistic outlook, AI still falls short of widespread clinical adoption in radiology. A 2020 survey by the American College of Radiology (ACR) revealed that only about a third of radiologists use AI, mostly to enhance image detection and interpretation; of the two thirds who did not use AI, the majority said they saw no benefit to it. In fact, most radiologists would say that AI has not transformed image reading or improved their practices.

One of the main challenges in autonomous robotic exploration and navigation in unknown and unstructured environments is determining where the robot can or cannot safely move. A significant source of difficulty in this determination arises from stochasticity and uncertainty, coming from localization error, sensor sparsity and noise, difficult-to-model robot-ground interactions, and disturbances to the motion of the vehicle. Classical approaches to this problem rely on geometric analysis of the surrounding terrain, which can be prone to modeling errors and can be computationally expensive. Moreover, modeling the distribution of uncertain traversability costs is a difficult task, compounded by the various error sources mentioned above. In this work, we take a principled learning approach to this problem. We introduce a neural network architecture for robustly learning the distribution of traversability costs. Because we are motivated by preserving the life of the robot, we tackle this learning problem from the perspective of learning tail-risks, i.e. the Conditional Value-at-Risk (CVaR). We show that this approach reliably learns the expected tail risk given a desired probability risk threshold between 0 and 1, producing a traversability costmap which is more robust to outliers, more accurately captures tail risks, and is more computationally efficient, when compared against baselines. We validate our method on data collected a legged robot navigating challenging, unstructured environments including an abandoned subway, limestone caves, and lava tube caves.

Reinforcement Learning (RL) requires a large amount of exploration especially in sparse-reward settings. Imitation Learning (IL) can learn from expert demonstrations without exploration, but it never exceeds the expert's performance and is also vulnerable to distributional shift between demonstration and execution. In this paper, we radically unify RL and IL based on Free Energy Principle (FEP). FEP is a unified Bayesian theory of the brain that explains perception, action and model learning by a common fundamental principle. We present a theoretical extension of FEP and derive an algorithm in which an agent learns the world model that internalizes expert demonstrations and at the same time uses the model to infer the current and future states and actions that maximize rewards. The algorithm thus reduces exploration costs by partially imitating experts as well as maximizing its return in a seamless way, resulting in a higher performance than the suboptimal expert. Our experimental results show that this approach is promising in visual control tasks especially in sparse-reward environments.