Polarization of the mammalian embryo at the right developmental time is critical for its development to term and would be valuable in assessing the potential of human embryos. However, tracking polarization requires invasive fluorescence staining, impermissible in the in vitro fertilization clinic. Here, we report the use of artificial intelligence to detect polarization from unstained time-lapse movies of mouse embryos. We assembled a dataset of bright-field movie frames from 8-cell-stage embryos, side-by-side with corresponding images of fluorescent markers of cell polarization. We then used an ensemble learning model to detect whether any bright-field frame showed an embryo before or after onset of polarization.

Graph Neural Networks have become one of the indispensable tools to learn from graph-structured data, and their usefulness has been shown in wide variety of tasks. In recent years, there have been tremendous improvements in architecture design, resulting in better performance on various prediction tasks. In general, these neural architectures combine node feature aggregation and feature transformation using learnable weight matrix in the same layer. This makes it challenging to analyze the importance of node features aggregated from various hops and the expressiveness of the neural network layers. As different graph datasets show varying levels of homophily and heterophily in features and class label distribution, it becomes essential to understand which features are important for the prediction tasks without any prior information. In this work, we decouple the node feature aggregation step and depth of graph neural network, and empirically analyze how different aggregated features play a role in prediction performance. We show that not all features generated via aggregation steps are useful, and often using these less informative features can be detrimental to the performance of the GNN model. Through our experiments, we show that learning certain subsets of these features can lead to better performance on wide variety of datasets. We propose to use softmax as a regularizer and "soft-selector" of features aggregated from neighbors at different hop distances; and L2-Normalization over GNN layers. Combining these techniques, we present a simple and shallow model, Feature Selection Graph Neural Network (FSGNN), and show empirically that the proposed model achieves comparable or even higher accuracy than state-of-the-art GNN models in nine benchmark datasets for the node classification task, with remarkable improvements up to 51.1%.

Attention mechanisms take an expectation of a data representation with respect to probability weights. This creates summary statistics that focus on important features. Recently, Martins et al. (2020; 2021) proposed continuous attention mechanisms, focusing on unimodal attention densities from the exponential and deformed exponential families: the latter has sparse support. Farinhas et al. (2021) extended this to use Gaussian mixture attention densities, which are a flexible class with dense support. In this paper, we extend this to two general flexible classes: kernel exponential families (Canu & Smola, 2006) and our new sparse counterpart kernel deformed exponential families. Theoretically, we show new existence results for both kernel exponential and deformed exponential families, and that the deformed case has similar approximation capabilities to kernel exponential families. Experiments show that kernel deformed exponential families can attend to multiple compact regions of the data domain. Attention mechanisms take weighted averages of data representations (Bahdanau et al., 2015), where the weights are a function of input objects. These are then used as inputs for prediction. Discrete attention 1) cannot easily handle data where observations are irregularly spaced 2) attention maps may be scattered, lacking focus.

Medical AI algorithms can often experience degraded performance when evaluated on previously unseen sites. Addressing cross-site performance disparities is key to ensuring that AI is equitable and effective when deployed on diverse patient populations. Multi-site evaluations are key to diagnosing such disparities as they can test algorithms across a broader range of potential biases such as patient demographics, equipment types, and technical parameters. However, such tests do not explain why the model performs worse. Our framework provides a method for quantifying the marginal and cumulative effect of each type of bias on the overall performance difference when a model is evaluated on external data. We demonstrate its usefulness in a case study of a deep learning model trained to detect the presence of pneumothorax, where our framework can help explain up to 60% of the discrepancy in performance across different sites with known biases like disease comorbidities and imaging parameters.

Obstacle avoidance for small unmanned aircraft is vital for the safety of future urban air mobility (UAM) and Unmanned Aircraft System (UAS) Traffic Management (UTM). There are many techniques for real-time robust drone guidance, but many of them solve in discretized airspace and control, which would require an additional path smoothing step to provide flexible commands for UAS. To provide a safe and efficient computational guidance of operations for unmanned aircraft, we explore the use of a deep reinforcement learning algorithm based on Proximal Policy Optimization (PPO) to guide autonomous UAS to their destinations while avoiding obstacles through continuous control. The proposed scenario state representation and reward function can map the continuous state space to continuous control for both heading angle and speed. To verify the performance of the proposed learning framework, we conducted numerical experiments with static and moving obstacles. Uncertainties associated with the environments and safety operation bounds are investigated in detail. Results show that the proposed model can provide accurate and robust guidance and resolve conflict with a success rate of over 99%.

Global Forecasting Models (GFM) that are trained across a set of multiple time series have shown superior results in many forecasting competitions and real-world applications compared with univariate forecasting approaches. One aspect of the popularity of statistical forecasting models such as ETS and ARIMA is their relative simplicity and interpretability (in terms of relevant lags, trend, seasonality, and others), while GFMs typically lack interpretability, especially towards particular time series. This reduces the trust and confidence of the stakeholders when making decisions based on the forecasts without being able to understand the predictions. To mitigate this problem, in this work, we propose a novel local model-agnostic interpretability approach to explain the forecasts from GFMs. We train simpler univariate surrogate models that are considered interpretable (e.g., ETS) on the predictions of the GFM on samples within a neighbourhood that we obtain through bootstrapping or straightforwardly as the one-step-ahead global black-box model forecasts of the time series which needs to be explained. After, we evaluate the explanations for the forecasts of the global models in both qualitative and quantitative aspects such as accuracy, fidelity, stability and comprehensibility, and are able to show the benefits of our approach.

The growing availability of the data collected from smart manufacturing is changing the paradigms of production monitoring and control. The increasing complexity and content of the wafer manufacturing process in addition to the time-varying unexpected disturbances and uncertainties, make it infeasible to do the control process with model-based approaches. As a result, data-driven soft-sensing modeling has become more prevalent in wafer process diagnostics. Recently, deep learning has been utilized in soft sensing system with promising performance on highly nonlinear and dynamic time-series data. Despite its successes in soft-sensing systems, however, the underlying logic of the deep learning framework is hard to understand. In this paper, we propose a deep learning-based model for defective wafer detection using a highly imbalanced dataset. To understand how the proposed model works, the deep visualization approach is applied. Additionally, the model is then fine-tuned guided by the deep visualization. Extensive experiments are performed to validate the effectiveness of the proposed system. The results provide an interpretation of how the model works and an instructive fine-tuning method based on the interpretation.

In the era of big data, data-driven based classification has become an essential method in smart manufacturing to guide production and optimize inspection. The industrial data obtained in practice is usually time-series data collected by soft sensors, which are highly nonlinear, nonstationary, imbalanced, and noisy. Most existing soft-sensing machine learning models focus on capturing either intra-series temporal dependencies or pre-defined inter-series correlations, while ignoring the correlation between labels as each instance is associated with multiple labels simultaneously. In this paper, we propose a novel graph based soft-sensing neural network (GraSSNet) for multivariate time-series classification of noisy and highly-imbalanced soft-sensing data. The proposed GraSSNet is able to 1) capture the inter-series and intra-series dependencies jointly in the spectral domain; 2) exploit the label correlations by superimposing label graph that built from statistical co-occurrence information; 3) learn features with attention mechanism from both textual and numerical domain; and 4) leverage unlabeled data and mitigate data imbalance by semi-supervised learning. Comparative studies with other commonly used classifiers are carried out on Seagate soft sensing data, and the experimental results validate the competitive performance of our proposed method.

There is an increasing convergence between biologically plausible computational models of inference and learning with local update rules and the global gradient-based optimization of neural network models employed in machine learning. One particularly exciting connection is the correspondence between the locally informed optimization in predictive coding networks and the error backpropagation algorithm that is used to train state-of-the-art deep artificial neural networks. Here we focus on the related, but still largely under-explored connection between precision weighting in predictive coding networks and the Natural Gradient Descent algorithm for deep neural networks. Precision-weighted predictive coding is an interesting candidate for scaling up uncertainty-aware optimization -- particularly for models with large parameter spaces -- due to its distributed nature of the optimization process and the underlying local approximation of the Fisher information metric, the adaptive learning rate that is central to Natural Gradient Descent. Here, we show that hierarchical predictive coding networks with learnable precision indeed are able to solve various supervised and unsupervised learning tasks with performance comparable to global backpropagation with natural gradients and outperform their classical gradient descent counterpart on tasks where high amounts of noise are embedded in data or label inputs. When applied to unsupervised auto-encoding of image inputs, the deterministic network produces hierarchically organized and disentangled embeddings, hinting at the close connections between predictive coding and hierarchical variational inference.

Over the past decade, we have seen exponential growth in online content fueled by social media platforms. Data generation of this scale comes with the caveat of insurmountable offensive content in it. The complexity of identifying offensive content is exacerbated by the usage of multiple modalities (image, language, etc.), code mixed language and more. Moreover, even if we carefully sample and annotate offensive content, there will always exist significant class imbalance in offensive vs non offensive content. In this paper, we introduce a novel Code-Mixing Index (CMI) based focal loss which circumvents two challenges (1) code mixing in languages (2) class imbalance problem for Dravidian language offense detection. We also replace the conventional dot product-based classifier with the cosine-based classifier which results in a boost in performance. Further, we use multilingual models that help transfer characteristics learnt across languages to work effectively with low resourced languages. It is also important to note that our model handles instances of mixed script (say usage of Latin and Dravidian - Tamil script) as well. Our model can handle offensive language detection in a low-resource, class imbalanced, multilingual and code mixed setting.