This work presents the development and evaluation of an NLP-enabled probabilistic classifier designed to estimate the probability of technical and regulatory success (pTRS) for clinical trials in the field of neuroscience. While pharmaceutical R&D is plagued by high attrition rates and enormous costs, particularly within neuroscience, where success rates are below 10%, timely identification of promising programs can streamline resource allocation and reduce financial risk. Leveraging data from the ClinicalTrials.gov database and success labels from the recently developed Clinical Trial Outcome dataset, the classifier extracts text-based clinical trial features using statistical NLP techniques. These features were integrated into several non-LLM frameworks (logistic regression, gradient boosting, and random forest) to generate calibrated probability scores. Model performance was assessed on a retrospective dataset of 101,145 completed clinical trials spanning 1976-2024, achieving an overall ROC-AUC of 0.64. An LLM-based predictive model was then built using BioBERT, a domain-specific language representation encoder. The BioBERT-based model achieved an overall ROC-AUC of 0.74 and a Brier Score of 0.185, indicating its predictions had, on average, 40% less squared error than would be observed using industry benchmarks. The BioBERT-based model also made trial outcome predictions that were superior to benchmark values 70% of the time overall. By integrating NLP-driven insights into drug development decision-making, this work aims to enhance strategic planning and optimize investment allocation in neuroscience programs.

Brain-Computer Interfaces (BCIs) based on Motor Execution (ME) and Motor Imagery (MI) electroencephalogram (EEG) signals offer a direct pathway for human-machine interaction. However, developing robust decoding models remains challenging due to the complex spatio-temporal dynamics of EEG, its low signal-to-noise ratio, and the limited generalizability of many existing approaches across subjects and paradigms. To address these issues, this paper proposes Graph-guided Clustering Mixture-of-Experts CNN-GRU (GCMCG), a novel unified framework for MI-ME EEG decoding. Our approach integrates a robust preprocessing stage using Independent Component Analysis and Wavelet Transform (ICA-WT) for effective denoising. We further introduce a pre-trainable graph tokenization module that dynamically models electrode relationships via a Graph Attention Network (GAT), followed by unsupervised spectral clustering to decompose signals into interpretable functional brain regions. Each region is processed by a dedicated CNN-GRU expert network, and a gated fusion mechanism with L1 regularization adaptively combines these local features with a global expert. This Mixture-of-Experts (MoE) design enables deep spatio-temporal fusion and enhances representational capacity. A three-stage training strategy incorporating focal loss and progressive sampling is employed to improve cross-subject generalization and handle class imbalance. Evaluated on three public datasets of varying complexity (EEGmmidb-BCI2000, BCI-IV 2a, and M3CV), GCMCG achieves overall accuracies of 86.60%, 98.57%, and 99.61%, respectively, which demonstrates its superior effectiveness and strong generalization capability for practical BCI applications.

Respiratory diseases remain major global health challenges, and traditional auscultation is often limited by subjectivity, environmental noise, and inter-clinician variability. This study presents an explainable multimodal deep learning framework for automatic lung-disease detection using respiratory audio signals. The proposed system integrates two complementary representations: a spectral-temporal encoder based on a CNN-BiLSTM Attention architecture, and a handcrafted acoustic-feature encoder capturing physiologically meaningful descriptors such as MFCCs, spectral centroid, spectral bandwidth, and zero-crossing rate. These branches are combined through late-stage fusion to leverage both data-driven learning and domain-informed acoustic cues. The model is trained and evaluated on the Asthma Detection Dataset Version 2 using rigorous preprocessing, including resampling, normalization, noise filtering, data augmentation, and patient-level stratified partitioning. The study achieved strong generalization with 91.21% accuracy, 0.899 macro F1-score, and 0.9866 macro ROC-AUC, outperforming all ablated variants. An ablation study confirms the importance of temporal modeling, attention mechanisms, and multimodal fusion. The framework incorporates Grad-CAM, Integrated Gradients, and SHAP, generating interpretable spectral, temporal, and feature-level explanations aligned with known acoustic biomarkers to build clinical transparency. The findings demonstrate the framework's potential for telemedicine, point-of-care diagnostics, and real-world respiratory screening.

The widespread deployment of Large Language Models (LLMs) has intensified concerns about subtle social biases embedded in their outputs. Existing guardrails often fail when faced with indirect or contextually complex bias-inducing prompts. To address these limitations, we propose a unified framework for both systematic bias evaluation and targeted mitigation. Our approach introduces six novel Metamorphic Relations (MRs) that, based on metamorphic testing principles, transform direct bias-inducing inputs into semantically equivalent yet adversarially challenging variants. These transformations enable an automated method for exposing hidden model biases: when an LLM responds inconsistently or unfairly across MR-generated variants, the underlying bias becomes detectable. We further show that the same MRs can be used to generate diverse bias-inducing samples for fine-tuning, directly linking the testing process to mitigation. Using six state-of-the-art LLMs - spanning open-source and proprietary models - and a representative subset of 385 questions from the 8,978-item BiasAsker benchmark covering seven protected groups, our MRs reveal up to 14% more hidden biases compared to existing tools. Moreover, fine-tuning with both original and MR-mutated samples significantly enhances bias resiliency, increasing safe response rates from 54.7% to over 88.9% across models. These results highlight metamorphic relations as a practical mechanism for improving fairness in conversational AI.

Generating realistic robotic manipulation videos is an important step toward unifying perception, planning, and action in embodied agents. While existing video diffusion models require large domain-specific datasets and struggle to generalize, recent image generation models trained on language-image corpora exhibit strong compositionality, including the ability to synthesize temporally coherent grid images. This suggests a latent capacity for video-like generation even without explicit temporal modeling. We explore whether such models can serve as visual planners for robots when lightly adapted using LoRA finetuning. We propose a two-part framework that includes: (1) text-conditioned generation, which uses a language instruction and the first frame, and (2) trajectory-conditioned generation, which uses a 2D trajectory overlay and the same initial frame. Experiments on the Jaco Play dataset, Bridge V2, and the RT1 dataset show that both modes produce smooth, coherent robot videos aligned with their respective conditions. Our findings indicate that pretrained image generators encode transferable temporal priors and can function as video-like robotic planners under minimal supervision. Code is released at \href{https://github.com/pangye202264690373/Image-Generation-as-a-Visual-Planner-for-Robotic-Manipulation}{https://github.com/pangye202264690373/Image-Generation-as-a-Visual-Planner-for-Robotic-Manipulation}.

Background: Autonomous agents powered by Large Language Models (LLMs) are driving a paradigm shift toward an "Internet of Agents" (IoA). While offering immense potential, this vision also introduces novel and systemic risks to safety and security. Objectives: Unlike common threat-centric taxonomies, our survey provides a principled, architectural framework for engineering safe and reliable agentic systems. We aim to identify the architectural sources of vulnerabilities to establish a foundation for secure design. Methods: We perform a bottom-up deconstruction of agentic systems, treating each component as a dual-use interface. The analysis spans three levels of complexity: the foundational Single Agent, the collaborative Multi-Agent System (MAS), and the visionary Interoperable Multi-Agent System (IMAS). At each level, we identify core architectural components and their inherent security risks. Results & Conclusions: Our central finding is that agentic safety is an architectural principle, not an add-on. By identifying specific vulnerabilities and deriving mitigation principles at each level of the agentic stack, this survey serves as a foundational guide for building the capable, safe, and trustworthy AI needed to realize a secure Internet of Agents.

In this thesis, we developed a comprehensive framework for sentiment analysis that takes its many aspects into account mainly for Turkish. We have also proposed several approaches specific to sentiment analysis in English only. We have accordingly made five major and three minor contributions. We generated a novel and effective feature set by combining unsupervised, semi-supervised, and supervised metrics. We then fed them as input into classical machine learning methods, and outperformed neural network models for datasets of different genres in both Turkish and English. We created a polarity lexicon with a semi-supervised domain-specific method, which has been the first approach applied for corpora in Turkish. We performed a fine morphological analysis for the sentiment classification task in Turkish by determining the polarities of morphemes. This can be adapted to other morphologically-rich or agglutinative languages as well. We have built a novel neural network architecture, which combines recurrent and recursive neural network models for English. We built novel word embeddings that exploit sentiment, syntactic, semantic, and lexical characteristics for both Turkish and English. We also redefined context windows as subclauses in modelling word representations in English. This can also be applied to other linguistic fields and natural language processing tasks. We have achieved state-of-the-art and significant results for all these original approaches. Our minor contributions include methods related to aspect-based sentiment in Turkish, parameter redefinition in the semi-supervised approach, and aspect term extraction techniques for English. This thesis can be considered the most detailed and comprehensive study made on sentiment analysis in Turkish as of July, 2020. Our work has also contributed to the opinion classification problem in English.

Recent reasoning large language models (LLMs) excel in complex tasks but encounter significant computational and memory challenges due to long sequence lengths. KV cache compression has emerged as an effective approach to greatly enhance the efficiency of reasoning. However, existing methods often focus on prompt compression or token eviction with local attention score, overlooking the long-term importance of tokens. We propose G-KV, a KV cache eviction method that employs a global scoring mechanism, combining local and historical attention scores to more accurately assess token importance. Additionally, we introduce post-training techniques, including reinforcement learning and distillation, to optimize models for compressed KV cache settings. The code of this paper is available on: https://github.com/microsoft/G-KV. Large language models (LLMs) have garnered widespread attention and applications. Recently released reasoning models have demonstrated remarkable performance (Guo et al., 2025; Team et al., 2025; Y ang et al., 2025), even in addressing complex tasks such as mathematics and coding. These reasoning models achieve significant improvements across various problems through long chain-of-thought (CoT) (Wei et al., 2022), enabling iterative reflection and verification. However, the long CoT of reasoning models typically consists of thousands or even tens of thousands of tokens. This imposes a substantial increase in computational costs and KV cache memory consumption. Notably, the computation of attention becomes a critical bottleneck, as its complexity scales quadratically with the sequence length. To overcome the bottlenecks of memory and computational complexity, numerous optimization methods for KV cache or attention mechanisms have been proposed (Li et al., 2024a). Among these, some methods prune the KV cache of tokens, significantly reducing computational overhead and memory consumption.

As deep learning models evolve, new applications and challenges are rapidly emerging. Tasks that once relied on a single modality, such as text, images, or audio, are now enriched by seamless interactions between multimodal data. These connections bridge information gaps: an image can visually materialize a text, while audio can add context to an image. Researchers have developed numerous multimodal models, but most rely on resource-intensive training across multiple modalities. Similarly, extending these models to new languages often follows the same resource-heavy training strategy. In this work, we propose a multimodal and multilingual architecture, CACARA, trained through emergent alignment learning, enabling the seamless integration of new modalities into an existing bimodal/multimodal model without requiring full retraining. This work breaks new ground by demonstrating that this emergent alignment paradigm can unlock multilingual capabilities from monolingual training. By fine-tuning the newly incorporated modality only on data aligned with the English language, our model develops support for over 100 languages without explicit multilingual pretraining or tuning of the text encoder. Such emergent multimodal and multilingual properties are gained efficiently, preserving previously learned knowledge at a training cost comparable to that of a monolingual model. Our strategy achieves up to a 14.24 percentage points improvement in R@1 audio-to-text retrieval, outperforming state-of-the-art multimodal models -- all without the heavy computational cost of retraining across every modality and language.

Data collection often reflects human decisions. In healthcare, for instance, a referral for a diagnostic test is influenced by the patient's health, their preferences, available resources, and the practitioner's recommendations. Despite the extensive literature on the informativeness of missingness, its implications on the performance of Large Language Models (LLMs) have not been studied. Through a series of experiments on data from Columbia University Medical Center, a large urban academic medical center, and MIMIC-IV, we demonstrate that patterns of missingness significantly impact zero-shot predictive performance. Notably, the explicit inclusion of missingness indicators at prompting benefits some while hurting other LLMs' zero-shot predictive performance and calibration, suggesting an inconsistent impact. The proposed aggregated analysis and theoretical insights suggest that larger models benefit from these interventions, while smaller models can be negatively impacted. The LLM paradigm risks obscuring the impact of missingness, often neglected even in conventional ML, even further. We conclude that there is a need for more transparent accounting and systematic evaluation of the impact of representing (informative) missingness on downstream performance.