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Multiparameter Uncertainty Mapping in Quantitative Molecular MRI using a Physics-Structured Variational Autoencoder (PS-VAE)

arXiv.org Machine Learning

Quantitative imaging methods, such as magnetic resonance fingerprinting (MRF), aim to extract interpretable pathology biomarkers by estimating biophysical tissue parameters from signal evolutions. However, the pattern-matching algorithms or neural networks used in such inverse problems often lack principled uncertainty quantification, which limits the trustworthiness and transparency, required for clinical acceptance. Here, we describe a physics-structured variational autoencoder (PS-VAE) designed for rapid extraction of voxelwise multi-parameter posterior distributions. Our approach integrates a differentiable spin physics simulator with self-supervised learning, and provides a full covariance that captures the inter-parameter correlations of the latent biophysical space. The method was validated in a multi-proton pool chemical exchange saturation transfer (CEST) and semisolid magnetization transfer (MT) molecular MRF study, across in-vitro phantoms, tumor-bearing mice, healthy human volunteers, and a subject with glioblastoma. The resulting multi-parametric posteriors are in good agreement with those calculated using a brute-force Bayesian analysis, while providing an orders-of-magnitude acceleration in whole brain quantification. In addition, we demonstrate how monitoring the multi-parameter posterior dynamics across progressively acquired signals provides practical insights for protocol optimization and may facilitate real-time adaptive acquisition.


Learning Better Certified Models from Empirically-Robust Teachers

arXiv.org Machine Learning

Adversarial training attains strong empirical robustness to specific adversarial attacks by training on concrete adversarial perturbations, but it produces neural networks that are not amenable to strong robustness certificates through neural network verification. On the other hand, earlier certified training schemes directly train on bounds from network relaxations to obtain models that are certifiably robust, but display sub-par standard performance. Recent work has shown that state-of-the-art trade-offs between certified robustness and standard performance can be obtained through a family of losses combining adversarial outputs and neural network bounds. Nevertheless, differently from empirical robustness, verifiability still comes at a significant cost in standard performance. In this work, we propose to leverage empirically-robust teachers to improve the performance of certifiably-robust models through knowledge distillation. Using a versatile feature-space distillation objective, we show that distillation from adversarially-trained teachers consistently improves on the state-of-the-art in certified training for ReLU networks across a series of robust computer vision benchmarks.


Evaluating LLMs When They Do Not Know the Answer: Statistical Evaluation of Mathematical Reasoning via Comparative Signals

arXiv.org Machine Learning

Evaluating mathematical reasoning in LLMs is constrained by limited benchmark sizes and inherent model stochasticity, yielding high-variance accuracy estimates and unstable rankings across platforms. On difficult problems, an LLM may fail to produce a correct final answer, yet still provide reliable pairwise comparison signals indicating which of two candidate solutions is better. We leverage this observation to design a statistically efficient evaluation framework that combines standard labeled outcomes with pairwise comparison signals obtained by having models judge auxiliary reasoning chains. Treating these comparison signals as control variates, we develop a semiparametric estimator based on the efficient influence function (EIF) for the setting where auxiliary reasoning chains are observed. This yields a one-step estimator that achieves the semiparametric efficiency bound, guarantees strict variance reduction over naive sample averaging, and admits asymptotic normality for principled uncertainty quantification. Across simulations, our one-step estimator substantially improves ranking accuracy, with gains increasing as model output noise grows. Experiments on GPQA Diamond, AIME 2025, and GSM8K further demonstrate more precise performance estimation and more reliable model rankings, especially in small-sample regimes where conventional evaluation is pretty unstable.


Score-based diffusion models for diffuse optical tomography with uncertainty quantification

arXiv.org Machine Learning

Score-based diffusion models are a recently developed framework for posterior sampling in Bayesian inverse problems with a state-of-the-art performance for severely ill-posed problems by leveraging a powerful prior distribution learned from empirical data. Despite generating significant interest especially in the machine-learning community, a thorough study of realistic inverse problems in the presence of modelling error and utilization of physical measurement data is still outstanding. In this work, the framework of unconditional representation for the conditional score function (UCoS) is evaluated for linearized difference imaging in diffuse optical tomography (DOT). DOT uses boundary measurements of near-infrared light to estimate the spatial distribution of absorption and scattering parameters in biological tissues. The problem is highly ill-posed and thus sensitive to noise and modelling errors. We introduce a novel regularization approach that prevents overfitting of the score function by constructing a mixed score composed of a learned and a model-based component. Validation of this approach is done using both simulated and experimental measurement data. The experiments demonstrate that a data-driven prior distribution results in posterior samples with low variance, compared to classical model-based estimation, and centred around the ground truth, even in the context of a highly ill-posed problem and in the presence of modelling errors.


NeuralFLoC: Neural Flow-Based Joint Registration and Clustering of Functional Data

arXiv.org Machine Learning

Clustering functional data in the presence of phase variation is challenging, as temporal misalignment can obscure intrinsic shape differences and degrade clustering performance. Most existing approaches treat registration and clustering as separate tasks or rely on restrictive parametric assumptions. We present \textbf{NeuralFLoC}, a fully unsupervised, end-to-end deep learning framework for joint functional registration and clustering based on Neural ODE-driven diffeomorphic flows and spectral clustering. The proposed model learns smooth, invertible warping functions and cluster-specific templates simultaneously, effectively disentangling phase and amplitude variation. We establish universal approximation guarantees and asymptotic consistency for the proposed framework. Experiments on functional benchmarks show state-of-the-art performance in both registration and clustering, with robustness to missing data, irregular sampling, and noise, while maintaining scalability. Code is available at https://anonymous.4open.science/r/NeuralFLoC-FEC8.


Improving the Linearized Laplace Approximation via Quadratic Approximations

arXiv.org Machine Learning

Deep neural networks (DNNs) often produce overconfident out-of-distribution predictions, motivating Bayesian uncertainty quantification. The Linearized Laplace Approximation (LLA) achieves this by lin-earizing the DNN and applying Laplace inference to the resulting model. Importantly, the linear model is also used for prediction. We argue this linearization in the posterior may degrade fidelity to the true Laplace approximation. To alleviate this problem, without increasing significantly the computational cost, we propose the Quadratic Laplace Approximation (QLA). QLA approximates each second order factor in the approximate Laplace log-posterior using a rank-one factor obtained via efficient power iterations. QLA is expected to yield a posterior precision closer to that of the full Laplace without forming the full Hessian, which is typically intractable. For prediction, QLA also uses the linearized model.


Self-Hinting Language Models Enhance Reinforcement Learning

arXiv.org Machine Learning

Group Relative Policy Optimization (GRPO) has recently emerged as a practical recipe for aligning large language models with verifiable objectives. However, under sparse terminal rewards, GRPO often stalls because rollouts within a group frequently receive identical rewards, causing relative advantages to collapse and updates to vanish. We propose self-hint aligned GRPO with privileged supervision (SAGE), an on-policy reinforcement learning framework that injects privileged hints during training to reshape the rollout distribution under the same terminal verifier reward. For each prompt $x$, the model samples a compact hint $h$ (e.g., a plan or decomposition) and then generates a solution $τ$ conditioned on $(x,h)$. Crucially, the task reward $R(x,τ)$ is unchanged; hints only increase within-group outcome diversity under finite sampling, preventing GRPO advantages from collapsing under sparse rewards. At test time, we set $h=\varnothing$ and deploy the no-hint policy without any privileged information. Moreover, sampling diverse self-hints serves as an adaptive curriculum that tracks the learner's bottlenecks more effectively than fixed hints from an initial policy or a stronger external model. Experiments over 6 benchmarks with 3 LLMs show that SAGE consistently outperforms GRPO, on average +2.0 on Llama-3.2-3B-Instruct, +1.2 on Qwen2.5-7B-Instruct and +1.3 on Qwen3-4B-Instruct. The code is available at https://github.com/BaohaoLiao/SAGE.


ChatGPT is back up after an outage disrupted use this afternoon

Engadget

Claude also went down for many users earlier today. If you had trouble using ChatGPT today, you aren't alone. The AI chatbot experienced a partial outage for many users this afternoon, with Down Detector saw reports reaching more than 12,000 reports around the peak point of the issue today.. OpenAI issued a status update shortly after noting that elevated error rates were occurring for ChatGPT and Platform users. That problem was marked as resolved at 5:14PM ET. While the initial outage may be repaired, OpenAI does still have an active status alert up. But the end may also be in sight for that final issue, because the current statement from the company is We have applied the mitigation and are monitoring the recovering.


ChatGPT is down for many users this afternoon

Engadget

We are working on implementing a mitigation, OpenAI said in a status update. If you've had trouble using ChatGPT today, you aren't alone. The AI chatbot is experiencing a partial outage for many users this afternoon. Down Detector reports of issues with the service leapt from almost nothing to more than 12,000 around 3PM ET. OpenAI issued a status update noting that elevated error rates are occurring for ChatGPT and Platform users.


Apple just made Xcode better for vibe coding

Engadget

Xcode 26.3 brings more robust support for programming agents like Claude. Apple has just released Xcode 26.3, and it's a big step forward in terms of the company's support of coding agents. The new release expands on the AI features the company introduced with Xcode 26 at WWDC 2025 to give systems like Claude and ChatGPT more robust access to its in-house IDE. With the update, Apple says Claude and OpenAI's Codex can search documentation, explore file structures, update project settings, and verify their work visually by capturing Xcode Previews and iterating through builds and fixes. This is in contrast to earlier releases of Xcode 26 where those same agents were limited in what they could see of a developer's Xcode environment, restricting their utility.