Deep generative models, such as generative adversarial networks (GANs), have been employed for $de~novo$ molecular generation in drug discovery. Most prior studies have utilized reinforcement learning (RL) algorithms, particularly Monte Carlo tree search (MCTS), to handle the discrete nature of molecular representations in GANs. However, due to the inherent instability in training GANs and RL models, along with the high computational cost associated with MCTS sampling, MCTS RL-based GANs struggle to scale to large chemical databases. To tackle these challenges, this study introduces a novel GAN based on actor-critic RL with instant and global rewards, called InstGAN, to generate molecules at the token-level with multi-property optimization. Furthermore, maximized information entropy is leveraged to alleviate the mode collapse. The experimental results demonstrate that InstGAN outperforms other baselines, achieves comparable performance to state-of-the-art models, and efficiently generates molecules with multi-property optimization. The source code will be released upon acceptance of the paper.

The burgeoning development of generative artificial intelligence (GenAI) and the widespread adoption of large language models (LLMs) in educational settings have sparked considerable debate regarding their efficacy and acceptability.Despite the potential benefits, the assimilation of these cutting-edge technologies among educators exhibits a broad spectrum of attitudes, from enthusiastic advocacy to profound skepticism.This study aims to dissect the underlying factors influencing educators' perceptions and acceptance of GenAI and LLMs.We conducted a survey among educators and analyzed the data through the frameworks of the Technology Acceptance Model (TAM) and Innovation Diffusion Theory (IDT). Our investigation reveals a strong positive correlation between the perceived usefulness of GenAI tools and their acceptance, underscoring the importance of demonstrating tangible benefits to educators. Additionally, the perceived ease of use emerged as a significant factor, though to a lesser extent, influencing acceptance. Our findings also show that the knowledge and acceptance of these tools is not uniform, suggesting that targeted strategies are required to address the specific needs and concerns of each adopter category to facilitate broader integration of AI tools.in education.

In an era where the Internet of Things (IoT) intersects increasingly with generative Artificial Intelligence (AI), this article scrutinizes the emergent security risks inherent in this integration. We explore how generative AI drives innovation in IoT and we analyze the potential for data breaches when using generative AI and the misuse of generative AI technologies in IoT ecosystems. These risks not only threaten the privacy and efficiency of IoT systems but also pose broader implications for trust and safety in AI-driven environments. The discussion in this article extends to strategic approaches for mitigating these risks, including the development of robust security protocols, the multi-layered security approaches, and the adoption of AI technological solutions. Through a comprehensive analysis, this article aims to shed light on the critical balance between embracing AI advancements and ensuring stringent security in IoT, providing insights into the future direction of these intertwined technologies.

History has a lesson for the development of artificial intelligence (AI): when in doubt, make it bigger. In "The Bitter Lesson," he argued that over its 70-year history, AI has succeeded when it has exploited available computing power. A series of papers published during the past decade that analyzed deep learning performance have confirmed the powerful effects of scaling up model size. This process accelerated in the wake of Google's development of the Transformer architecture for the BERT large language models (LLMs). Model size, measured by the number of stored neural weights, ballooned in just five years. From BERT's 340 million parameters, today's largest implementations, known as frontier models, such as OpenAI's GPT-4 have pushed beyond a trillion.

This study investigates the efficacy of six major Generative AI (GenAI) text detectors when confronted with machine-generated content that has been modified using techniques designed to evade detection by these tools (n=805). The results demonstrate that the detectors' already low accuracy rates (39.5%) show major reductions in accuracy (17.4%) when faced with manipulated content, with some techniques proving more effective than others in evading detection. The accuracy limitations and the potential for false accusations demonstrate that these tools cannot currently be recommended for determining whether violations of academic integrity have occurred, underscoring the challenges educators face in maintaining inclusive and fair assessment practices. However, they may have a role in supporting student learning and maintaining academic integrity when used in a non-punitive manner. These results underscore the need for a combined approach to addressing the challenges posed by GenAI in academia to promote the responsible and equitable use of these emerging technologies. The study concludes that the current limitations of AI text detectors require a critical approach for any possible implementation in HE and highlight possible alternatives to AI assessment strategies.

Generative Adversarial Networks (GANs) have shown great success in generating high quality images and are thus used as one of the main approaches to generate art images. However, usually the image generation process involves sampling from the latent space of the learned art representations, allowing little control over the output. In this work, we first employ GANs that are trained to produce creative images using an architecture known as Creative Adversarial Networks (CANs), then, we employ an evolutionary approach to navigate within the latent space of the models to discover images. We use automatic aesthetic and collaborative interactive human evaluation metrics to assess the generated images. In the human interactive evaluation case, we propose a collaborative evaluation based on the assessments of several participants. Furthermore, we also experiment with an intelligent mutation operator that aims to improve the quality of the images through local search based on an aesthetic measure. We evaluate the effectiveness of this approach by comparing the results produced by the automatic and collaborative interactive evolution. The results show that the proposed approach can generate highly attractive art images when the evolution is guided by collaborative human feedback.

Large Language Models (LLMs) have recently emerged as a focal point of research and application, driven by their unprecedented ability to understand and generate text with human-like quality. Even more recently, LLMs have been extended into multi-modal large language models (MM-LLMs) which extends their capabilities to deal with image, video and audio information, in addition to text. This opens up applications like text-to-video generation, image captioning, text-to-speech, and more and is achieved either by retro-fitting an LLM with multi-modal capabilities, or building a MM-LLM from scratch. This paper provides an extensive review of the current state of those LLMs with multi-modal capabilities as well as the very recent MM-LLMs. It covers the historical development of LLMs especially the advances enabled by transformer-based architectures like OpenAI's GPT series and Google's BERT, as well as the role of attention mechanisms in enhancing model performance. The paper includes coverage of the major and most important of the LLMs and MM-LLMs and also covers the techniques of model tuning, including fine-tuning and prompt engineering, which tailor pre-trained models to specific tasks or domains. Ethical considerations and challenges, such as data bias and model misuse, are also analysed to underscore the importance of responsible AI development and deployment. Finally, we discuss the implications of open-source versus proprietary models in AI research. Through this review, we provide insights into the transformative potential of MM-LLMs in various applications.

Amazon said on Wednesday it will pour an additional 2.75bn into Anthropic, bringing its total investment in the artificial intelligence startup to 4bn. The technology giant will maintain a minority stake in San Francisco-based Anthropic, a rival of ChatGPT maker OpenAI. "Generative AI is poised to be the most transformational technology of our time, and we believe our strategic collaboration with Anthropic will further improve our customers' experiences, and look forward to what's next," said Swami Sivasubramanian, vice-president of data and AI at Amazon Web Services, or AWS, Amazon's cloud-computing subsidiary. The Seattle-based tech giant made an initial investment of 1.25bn in Anthropic in September, and indicated then it had plans to invest up to 4bn. Get set for the working day – we'll point you to all the business news and analysis you need every morning The two companies are collaborating to develop so-called foundation models, which underpin the generative AI systems that have captured global attention.

This past Monday, about a dozen engineers and executives at data science and AI company Databricks gathered in conference rooms connected via Zoom to learn if they had succeeded in building a top artificial intelligence language model. The team had spent months, and about 10 million, training DBRX, a large language model similar in design to the one behind OpenAI's ChatGPT. But they wouldn't know how powerful their creation was until results came back from the final tests of its abilities. "We've surpassed everything," Jonathan Frankle, chief neural network architect at Databricks and leader of the team that built DBRX, eventually told the team, which responded with whoops, cheers, and applause emojis. Frankle usually steers clear of caffeine but was taking sips of iced latte after pulling an all-nighter to write up the results.

When the board of OpenAI staged a bum mutiny last November, throwing out the company's leadership only to have the bosses return while board members were pressured to resign, something seemed rotten in the state of effective altruism. Nominally, OpenAI's mission had been to ensure that AI "benefits all of humanity." Fiduciarily, OpenAI's mission is to benefit the subset of humanity with a stake in OpenAI. And then, of course, there was Sam Bankman-Fried, the felonious altruist who argued in court last fall that his sordid crypto exchange was in fact a noble exercise in earning-to-give--making Midas money, sure, but only to funnel it to the global poor. This week he's facing a prison sentence of up to 50 years, which his legal team has complained paints him as a "depraved super-villain."