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Analysis of Brain States from Multi-Region LFP Time-Series

Neural Information Processing Systems

The local field potential (LFP) is a source of information about the broad patterns of brain activity, and the frequencies present in these time-series measurements are often highly correlated between regions. It is believed that these regions may jointly constitute a "brain state," relating to cognition and behavior. An infinite hidden Markov model (iHMM) is proposed to model the evolution of brain states, based on electrophysiological LFP data measured at multiple brain regions. A brain state influences the spectral content of each region in the measured LFP . A new state-dependent tensor factorization is employed across brain regions, and the spectral properties of the LFPs are characterized in terms of Gaussian processes (GPs). The LFPs are modeled as a mixture of GPs, with state-and region-dependent mixture weights, and with the spectral content of the data encoded in GP spectral mixture covariance kernels. The model is able to estimate the number of brain states and the number of mixture components in the mixture of GPs. A new variational Bayesian split-merge algorithm is employed for inference. The model infers state changes as a function of external covariates in two novel elec-trophysiological datasets, using LFP data recorded simultaneously from multiple brain regions in mice; the results are validated and interpreted by subject-matter experts.


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Neural Information Processing Systems

First provide a summary of the paper, and then address the following criteria: Quality, clarity, originality and significance. In this paper, authors analyze sparsity of the posterior parameters in LDA using a variational Bayesian algorithm. They derive an expression for the VB free energy which shows its asymptotic behaviour with respect to number of words (N), number of documents (M), vocabulary size (L) etc. Their results suggest that, for certain settings of L,M,N, the sparsity behaviour changes drastically at a particular hyper-parameter setting. These changes differ from those of MAP and partial-Bayes algorithms. The problem discussed in this paper is original, interesting, and is perhaps useful too.


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Neural Information Processing Systems

First provide a summary of the paper, and then address the following criteria: Quality, clarity, originality and significance. This paper combines evidence-based clustering with an importance sampling approach. It further optimizes the weight function calculation of importance sampling, by using a second sampler to estimate the number of true groundings. I recommend to accept this paper because of the importance of the evidence problem, and the fact that the proposed solution is very general and scalable. The paper is well-written and clear, except for Figure 1 (b) and Equations 5,6, and 7, which are poorly explained.




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Neural Information Processing Systems

First provide a summary of the paper, and then address the following criteria: Quality, clarity, originality and significance. This paper proposes the Latent Case Model (LCM), a Bayesian approach to clustering in which clusters are represented by a prototype (a specific sample from the data) and feature subspaces (a binary subset of the variables signifying those features that are relevant to the class). The approach is presented as being a Bayesian, trainable version of the Case-Based Reasoning approach popular in AI, and is motivated by the ways such models have proved highly effective in explaining human decision making. The generative model (Figure 1) represents each item as coming from a mixture of S clusters, where each cluster is represented by a prototype and subspace (as above) and a function \phi which generates features matching those of the prototype with high probability for features in the subspace, and uniform features outside it. The model is thus similar in functionality to LDA but quite different in terms of its representation.




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Neural Information Processing Systems

First provide a summary of the paper, and then address the following criteria: Quality, clarity, originality and significance. This paper considers weighted majority algorithm and establishes consistency (error rate of the aggregator tending to zero) results under two settings: (1) when the competence level (risk of each expert) is known in advance and (2) when it is estimated. For case (2), frequentist and Bayesian methods for estimating the competence level are provided. For case (1), consistency is established in terms of providing upper and lower bounds on the error rate of the aggregator, which involve standard calculations ( apart from the fact that upper bound is established by invoking a result by Kearns and Saul, instead of Hoeffding's inequality). For case (2) under the frequentist setting, an independent set of labeled inputs is used to estimate the competence level of each expert.