So you know the Bayes rule. How does it relate to machine learning? It can be quite difficult to grasp how the puzzle pieces fit together - we know it took us a while. This article is an introduction we wish we had back then. While we have some grasp on the matter, we're not experts, so the following might contain inaccuracies or even outright errors. Feel free to point them out, either in the comments or privately.

Coregulation of the expression of groups of genes has been extensively demonstrated empirically in bacterial and eukaryotic systems. Such coregulation can arise through the use of shared regulatory motifs, which allow the coordinated expression of modules (and module groups) of functionally related genes across the genome. Coregulation can also arise through the physical association of multi-gene complexes through chromosomal looping, which are then transcribed together. We present a general formalism for modeling coregulation rules in the framework of Random Boolean Networks (RBN), and develop specific models for transcription factor networks with modular structure (including module groups, and multi-input modules (MIM) with autoregulation) and multi-gene complexes (including hierarchical differentiation between multi-gene complex members). We develop a mean-field approach to analyse the stability of large networks incorporating coregulation, and show that autoregulated MIM and hierarchical gene-complex models can achieve greater stability than networks without coregulation whose rules have matching activation frequency. We provide further analysis of the stability of small networks of both kinds through simulations. We also characterize several general properties of the transients and attractors in the hierarchical coregulation model, and show using simulations that the steady-state distribution factorizes hierarchically as a Bayesian network in a Markov Jump Process analogue of the RBN model.

Its a constant that you use to normalize, right? And what comes after the normalizing constant in the equation is a vector, right? The authors are using Z' so that you know that the vector always gets normalized, you don't just calculate a constant at the start of training and reuse the same constant each time you calculate as the vector moves off normal.

We revisit the development of grid based recursive approximate filtering of general Markov processes in discrete time, partially observed in conditionally Gaussian noise. The grid based filters considered rely on two types of state quantization: The \textit{Markovian} type and the \textit{marginal} type. We propose a set of novel, relaxed sufficient conditions, ensuring strong and fully characterized pathwise convergence of these filters to the respective MMSE state estimator. In particular, for marginal state quantizations, we introduce the notion of \textit{conditional regularity of stochastic kernels}, which, to the best of our knowledge, constitutes the most relaxed condition proposed, under which asymptotic optimality of the respective grid based filters is guaranteed. Further, we extend our convergence results, including filtering of bounded and continuous functionals of the state, as well as recursive approximate state prediction. For both Markovian and marginal quantizations, the whole development of the respective grid based filters relies more on linear-algebraic techniques and less on measure theoretic arguments, making the presentation considerably shorter and technically simpler.

We study the problem of learning sparse structure changes between two Markov networks $P$ and $Q$. Rather than fitting two Markov networks separately to two sets of data and figuring out their differences, a recent work proposed to learn changes \emph{directly} via estimating the ratio between two Markov network models. In this paper, we give sufficient conditions for \emph{successful change detection} with respect to the sample size $n_p, n_q$, the dimension of data $m$, and the number of changed edges $d$. When using an unbounded density ratio model we prove that the true sparse changes can be consistently identified for $n_p = \Omega(d^2 \log \frac{m^2+m}{2})$ and $n_q = \Omega({n_p^2})$, with an exponentially decaying upper-bound on learning error. Such sample complexity can be improved to $\min(n_p, n_q) = \Omega(d^2 \log \frac{m^2+m}{2})$ when the boundedness of the density ratio model is assumed. Our theoretical guarantee can be applied to a wide range of discrete/continuous Markov networks.

Covariance Is 0 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

KNN can easily be mapped to our real lives. If you want to learn about a person, of whom you have no information, you might like to find out about his close friends and the circles he moves in and gain access to his/her information! It is a type of unsupervised algorithm which solves the clustering problem. Its procedure follows a simple and easy way to classify a given data set through a certain number of clusters (assume k clusters). Data points inside a cluster are homogeneous and heterogeneous to peer groups. Remember figuring out shapes from ink blots?

Welcome to the natural language processing (NLP) edition of my "under-the-hood" series on AI (artificial intelligence) technology. Most major tech companies are announcing initiatives, introducing products (e.g., Amazon (NASDAQ:AMZN) with its Echo device and platform) or experiments in public (e.g., Microsoft's (NASDAQ:MSFT) Tay debacle). On Seeking Alpha (and I am sure in many other places as well), the topic of natural language processing seems to be confusing many people because they are not clear on what new technologies here can do and what they should expect from them in the immediate future. Even though I have touched on the subject before - e.g. on my explanation of IBM's (NYSE:IBM) Watson - I feel like I have not explained the specific topic of natural language processing comprehensively. There is a specific reason why the topic is getting so much attention and it has to do with the convergence of various subfields of computer science and statistics.

This work is motivated by the needs of predictive analytics on healthcare data as represented by Electronic Medical Records. Such data is invariably problematic: noisy, with missing entries, with imbalance in classes of interests, leading to serious bias in predictive modeling. Since standard data mining methods often produce poor performance measures, we argue for development of specialized techniques of data-preprocessing and classification. In this paper, we propose a new method to simultaneously classify large datasets and reduce the effects of missing values. It is based on a multilevel framework of the cost-sensitive SVM and the expected maximization imputation method for missing values, which relies on iterated regression analyses. We compare classification results of multilevel SVM-based algorithms on public benchmark datasets with imbalanced classes and missing values as well as real data in health applications, and show that our multilevel SVM-based method produces fast, and more accurate and robust classification results.

While perception tasks such as visual object recognition and text understanding play an important role in human intelligence, the subsequent tasks that involve inference, reasoning and planning require an even higher level of intelligence. The past few years have seen major advances in many perception tasks using deep learning models. For higher-level inference, however, probabilistic graphical models with their Bayesian nature are still more powerful and flexible. To achieve integrated intelligence that involves both perception and inference, it is naturally desirable to tightly integrate deep learning and Bayesian models within a principled probabilistic framework, which we call Bayesian deep learning. In this unified framework, the perception of text or images using deep learning can boost the performance of higher-level inference and in return, the feedback from the inference process is able to enhance the perception of text or images. This survey provides a general introduction to Bayesian deep learning and reviews its recent applications on recommender systems, topic models, and control. In this survey, we also discuss the relationship and differences between Bayesian deep learning and other related topics like Bayesian treatment of neural networks.