According to the American Cancer Society, cancer kills more than 8 million people each year. Early detection can boost survival rates. Researchers and clinicians are feverishly exploring avenues to provide early and accurate diagnoses, as well as more targeted treatments. Blood screenings are used to detect many types of cancers, including liver, ovarian, colon and lung cancers. Current blood screening methods typically rely on affixing biochemical labels to cells or biomolecules.

Sum-Product Networks (SPN) have recently emerged as a new class of tractable probabilistic graphical models. Unlike Bayesian networks and Markov networks where inference may be exponential in the size of the network, inference in SPNs is in time linear in the size of the network. Since SPNs represent distributions over a fixed set of variables only, we propose dynamic sum product networks (DSPNs) as a generalization of SPNs for sequence data of varying length. A DSPN consists of a template network that is repeated as many times as needed to model data sequences of any length. We present a local search technique to learn the structure of the template network. In contrast to dynamic Bayesian networks for which inference is generally exponential in the number of variables per time slice, DSPNs inherit the linear inference complexity of SPNs. We demonstrate the advantages of DSPNs over DBNs and other models on several datasets of sequence data.

Causal modeling has long been an attractive topic for many researchers and in recent decades there has seen a surge in theoretical development and discovery algorithms. Generally discovery algorithms can be divided into two approaches: constraint-based and score-based. The constraint-based approach is able to detect common causes of the observed variables but the use of independence tests makes it less reliable. The score-based approach produces a result that is easier to interpret as it also measures the reliability of the inferred causal relationships, but it is unable to detect common confounders of the observed variables. A drawback of both score-based and constrained-based approaches is the inherent instability in structure estimation. With finite samples small changes in the data can lead to completely different optimal structures. The present work introduces a new hypothesis-free score-based causal discovery algorithm, called stable specification search, that is robust for finite samples based on recent advances in stability selection using subsampling and selection algorithms. Structure search is performed over Structural Equation Models. Our approach uses exploratory search but allows incorporation of prior background knowledge. We validated our approach on one simulated data set, which we compare to the known ground truth, and two real-world data sets for Chronic Fatigue Syndrome and Attention Deficit Hyperactivity Disorder, which we compare to earlier medical studies. The results on the simulated data set show significant improvement over alternative approaches and the results on the real-word data sets show consistency with the hypothesis driven models constructed by medical experts.

So you know the Bayes rule. How does it relate to machine learning? It can be quite difficult to grasp how the puzzle pieces fit together - we know it took us a while. This article is an introduction we wish we had back then. While we have some grasp on the matter, we're not experts, so the following might contain inaccuracies or even outright errors. Feel free to point them out, either in the comments or privately.

It is no doubt that the sub-field of machine learning / artificial intelligence has increasingly gained more popularity in the past couple of years. As Big Data is the hottest trend in the tech industry at the moment, machine learning is incredibly powerful to make predictions or calculated suggestions based on large amounts of data. Some of the most common examples of machine learning are Netflix's algorithms to make movie suggestions based on movies you have watched in the past or Amazon's algorithms that recommend books based on books you have bought before. So if you want to learn more about machine learning, how do you start? For me, my first introduction is when I took an Artificial Intelligence class when I was studying abroad in Copenhagen.

In a recent issue of Nature Scientific Reports, a multidisciplinary team of UCLA researchers combined a new form of microscopy called photonic time-stretch imaging with deep learning. With this powerful new technique, they were able to capture 36 million video frames per second. Not content with simply developing a new technique, the team then utilized the augmented microscope to determine which strains of algae provide the most lipids for subsequent refining into biofuels. They also were able to detect cancer cells more accurately and in less time than current techniques. Yes, one methodology that tackled both biofuels and cancer.

We describe parallel Markov chain Monte Carlo methods that propagate a collective ensemble of paths, with local covariance information calculated from neighboring replicas. The use of collective dynamics eliminates multiplicative noise and stabilizes the dynamics thus providing a practical approach to difficult anisotropic sampling problems in high dimensions. Numerical experiments with model problems demonstrate that dramatic potential speedups, compared to various alternative schemes, are attainable.

Many problems in science and engineering can be formulated as a sequential decision-making problem under uncertainty. A common scenario in such problems that occurs in many different fields, such as online marketing, inventory control, health informatics, and computational finance, is to find a good or an optimal strategy/policy, given a batch of data generated by the current strategy of the company (hospital, investor). Although there are many techniques to find a good policy given a batch of data, only a few of them guarantee that the obtained policy will perform well, when it is deployed. Since deploying an untested policy can be risky for the business, the product (hospital, investment) manager does not usually allow it to happen, unless we provide her/him with some performance guarantees of the obtained strategy, in comparison to the baseline policy (e.g., the policy that is currently in use). In this paper, we focus on the model-based approach to this fundamental problem in the context of infinite-horizon discounted Markov decision processes (MDPs). In this approach, we use the batch of data and build a model or a simulator that approximates the true behavior of the dynamical system, together with an error function that captures the accuracy of the model at each state of the system. Our goal is to compute a safe policy, i.e., a policy that is guaranteed to perform at least as well as the baseline strategy, using the simulator and error function. Most of the work on this topic has been in the model-free setting, where safe policies are computed directly from the batch of data, without building an explicit model of the system [12, 13]. Another class of model-free algorithms are those that use a batch of data generated by the current policy and return a policy that is guaranteed to perform better.

In this work, we consider a manufactory process which can be described by a multiple-instance logistic regression model. In order to compute the maximum likelihood estimation of the unknown coefficient, an expectation-maximization algorithm is proposed, and the proposed modeling approach can be extended to identify the important covariates by adding the coefficient penalty term into the likelihood function. In addition to essential technical details, we demonstrate the usefulness of the proposed method by simulations and real examples.

This paper focuses on causal structure estimation from time series data in which measurements are obtained at a coarser timescale than the causal timescale of the underlying system. Previous work has shown that such subsampling can lead to significant errors about the system's causal structure if not properly taken into account. In this paper, we first consider the search for the system timescale causal structures that correspond to a given measurement timescale structure. We provide a constraint satisfaction procedure whose computational performance is several orders of magnitude better than previous approaches. We then consider finite-sample data as input, and propose the first constraint optimization approach for recovering the system timescale causal structure. This algorithm optimally recovers from possible conflicts due to statistical errors. More generally, these advances allow for a robust and non-parametric estimation of system timescale causal structures from subsampled time series data.