Traditional voxel-level multiple testing procedures in neuroimaging, mostly $p$-value based, often ignore the spatial correlations among neighboring voxels and thus suffer from substantial loss of power. We extend the local-significance-index based procedure originally developed for the hidden Markov chain models, which aims to minimize the false nondiscovery rate subject to a constraint on the false discovery rate, to three-dimensional neuroimaging data using a hidden Markov random field model. A generalized expectation-maximization algorithm for maximizing the penalized likelihood is proposed for estimating the model parameters. Extensive simulations show that the proposed approach is more powerful than conventional false discovery rate procedures. We apply the method to the comparison between mild cognitive impairment, a disease status with increased risk of developing Alzheimer's or another dementia, and normal controls in the FDG-PET imaging study of the Alzheimer's Disease Neuroimaging Initiative.

We study the issue of PAC-Bayesian domain adaptation: We want to learn, from a source domain, a majority vote model dedicated to a target one. Our theoretical contribution brings a new perspective by deriving an upper-bound on the target risk where the distributions' divergence---expressed as a ratio---controls the trade-off between a source error measure and the target voters' disagreement. Our bound suggests that one has to focus on regions where the source data is informative.From this result, we derive a PAC-Bayesian generalization bound, and specialize it to linear classifiers. Then, we infer a learning algorithmand perform experiments on real data.

Mixture models with Gamma and or inverse-Gamma distributed mixture components are useful for medical image tissue segmentation or as post-hoc models for regression coefficients obtained from linear regression within a Generalised Linear Modeling framework (GLM), used in this case to separate stochastic (Gaussian) noise from some kind of positive or negative "activation" (modeled as Gamma or inverse-Gamma distributed). To date, the most common choice in this context it is Gaussian/Gamma mixture models learned through a maximum likelihood (ML) approach; we recently extended such algorithm for mixture models with inverse-Gamma components. Here, we introduce a fully analytical Variational Bayes (VB) learning framework for both Gamma and/or inverse-Gamma components. We use synthetic and resting state fMRI data to compare the performance of the ML and VB algorithms in terms of area under the curve and computational cost. We observed that the ML Gaussian/Gamma model is very expensive specially when considering high resolution images; furthermore, these solutions are highly variable and they occasionally can overestimate the activations severely. The Bayesian Gauss-Gamma is in general the fastest algorithm but provides too dense solutions. The maximum likelihood Gaussian/inverse-Gamma is also very fast but provides in general very sparse solutions. The variational Gaussian/inverse-Gamma mixture model is the most robust and its cost is acceptable even for high resolution images. Further, the presented methodology represents an essential building block that can be directly used in more complex inference tasks, specially designed to analyse MRI-fMRI data; such models include for example analytical variational mixture models with adaptive spatial regularization or better source models for new spatial blind source separation approaches.

Least squares regression can cause impossible estimates such as probabilities that are less than zero and greater than 1.So, when the predicted value is measured as a probability, use Logistic Regression We use the log of the odds rather than the odds directly because an odds ratio cannot be a negative number--but its log can be negative. Notice that we have randomly initialized our coefficients for income and other predictors. These will be adjusted by Solver based on a likelihood function.We will cover them later Column H tells us the predicted probability of the borrower's actual behavior, whether that behavior is repayment or default--not simply, as in Column G, the predicted probability of defaulting on the loan. One property of logarithms is that their sum equals the logarithm of the product of the numbers on which they're based The logarithms of probabilities are always negative numbers, but the closer a probability is to 1.0, the closer its logarithm is to 0.0. I haven't covered cross-validation, which is commonly used to validate a logistic regression equation.If you don't always have a large number of cases to work with, a different approach is to use statistical inference.

Weka makes a large number of classification algorithms available. The large number of machine learning algorithms available is one of the benefits of using the Weka platform to work through your machine learning problems. In this post you will discover how to use 5 top machine learning algorithms in Weka. How To Use Classification Machine Learning Algorithms in Weka Photo by Don Graham, some rights reserved. We are going to take a tour of 5 top classification algorithms in Weka.

Social media has recently emerged as a premier method to disseminate information online. Through these online networks, tens of millions of individuals communicate their thoughts, personal experiences, and social ideals. We therefore explore the potential of social media to predict, even prior to onset, Major Depressive Disorder (MDD) in online personas. We employ a crowdsourced method to compile a list of Twitter users who profess to being diagnosed with depression. Using up to a year of prior social media postings, we utilize a Bag of Words approach to quantify each tweet. Lastly, we leverage several statistical classifiers to provide estimates to the risk of depression. Our work posits a new methodology for constructing our classifier by treating social as a text-classification problem, rather than a behavioral one on social media platforms. By using a corpus of 2.5M tweets, we achieved an 81% accuracy rate in classification, with a precision score of .86. We believe that this method may be helpful in developing tools that estimate the risk of an individual being depressed, can be employed by physicians, concerned individuals, and healthcare agencies to aid in diagnosis, even possibly enabling those suffering from depression to be more proactive about recovering from their mental health.

Semantic word embeddings represent the meaning of a word via a vector, and are created by diverse methods. Many use nonlinear operations on co-occurrence statistics, and have hand-tuned hyperparameters and reweighting methods. This paper proposes a new generative model, a dynamic version of the log-linear topic model of~\citet{mnih2007three}. The methodological novelty is to use the prior to compute closed form expressions for word statistics. This provides a theoretical justification for nonlinear models like PMI, word2vec, and GloVe, as well as some hyperparameter choices. It also helps explain why low-dimensional semantic embeddings contain linear algebraic structure that allows solution of word analogies, as shown by~\citet{mikolov2013efficient} and many subsequent papers. Experimental support is provided for the generative model assumptions, the most important of which is that latent word vectors are fairly uniformly dispersed in space.

We propose a Laplace approximation that creates a stochastic unit from any smooth monotonic activation function, using only Gaussian noise. This paper investigates the application of this stochastic approximation in training a family of Restricted Boltzmann Machines (RBM) that are closely linked to Bregman divergences. This family, that we call exponential family RBM (Exp-RBM), is a subset of the exponential family Harmoniums that expresses family members through a choice of smooth monotonic non-linearity for each neuron. Using contrastive divergence along with our Gaussian approximation, we show that Exp-RBM can learn useful representations using novel stochastic units.

The causal discovery of Bayesian networks is an active and important research area, and it is based upon searching the space of causal models for those which can best explain a pattern of probabilistic dependencies shown in the data. However, some of those dependencies are generated by causal structures involving variables which have not been measured, i.e., latent variables. Some such patterns of dependency "reveal" themselves, in that no model based solely upon the observed variables can explain them as well as a model using a latent variable. That is what latent variable discovery is based upon. Here we did a search for finding them systematically, so that they may be applied in latent variable discovery in a more rigorous fashion.

Artificial intelligence (AI) is intelligence exhibited by machines. In computer science, an ideal "intelligent" machine is a flexible rational agent that perceives its environment and takes actions that maximize its chance of success at some goal.[1] Colloquially, the term "artificial intelligence" is applied when a machine mimics "cognitive" functions that humans associate with other human minds, such as "learning" and "problem solving".[2] As machines become increasingly capable, facilities once thought to require intelligence are removed from the definition. For example, optical character recognition is no longer perceived as an exemplar of "artificial intelligence" having become a routine technology.[3] Capabilities still classified as AI include advanced Chess and Go systems and self-driving cars. AI research is divided into subfields[4] that focus on specific problems or on specific approaches or on the use of a particular tool or towards satisfying particular applications. The central problems (or goals) of AI research include reasoning, knowledge, planning, learning, natural language processing (communication), perception and the ability to move and manipulate objects.[5] General intelligence is among the field's long-term goals.[6] Approaches include statistical methods, computational intelligence, soft computing (e.g. machine learning), and traditional symbolic AI. Many tools are used in AI, including versions of search and mathematical optimization, logic, methods based on probability and economics. The AI field draws upon computer science, mathematics, psychology, linguistics, philosophy, neuroscience and artificial psychology. The field was founded on the claim that human intelligence "can be so precisely described that a machine can be made to simulate it."[7] This raises philosophical arguments about the nature of the mind and the ethics of creating artificial beings endowed with human-like intelligence, issues which have been explored by myth, fiction and philosophy since antiquity.[8] Attempts to create artificial intelligence has experienced many setbacks, including the ALPAC report of 1966, the abandonment of perceptrons in 1970, the Lighthill Report of 1973 and the collapse of the Lisp machine market in 1987. In the twenty-first century AI techniques became an essential part of the technology industry, helping to solve many challenging problems in computer science.[9]