This paper is concerned with the problem of stochastic control of gene regulatory networks (GRNs) observed indirectly through noisy measurements and with uncertainty in the intervention inputs. The partial observability of the gene states and uncertainty in the intervention process are accounted for by modeling GRNs using the partially-observed Boolean dynamical system (POBDS) signal model with noisy gene expression measurements. Obtaining the optimal infinite-horizon control strategy for this problem is not attainable in general, and we apply reinforcement learning and Gaussian process techniques to find a near-optimal solution. The POBDS is first transformed to a directly-observed Markov Decision Process in a continuous belief space, and the Gaussian process is used for modeling the cost function over the belief and intervention spaces. Reinforcement learning then is used to learn the cost function from the available gene expression data. In addition, we employ sparsification, which enables the control of large partially-observed GRNs. The performance of the resulting algorithm is studied through a comprehensive set of numerical experiments using synthetic gene expression data generated from a melanoma gene regulatory network.

For many internet businesses, presenting a given list of items in an order that maximizes a certain metric of interest (e.g., click-through-rate, average engagement time etc.) is crucial. We approach the aforementioned task from a learning-to-rank perspective which reveals a new problem setup. In traditional learning-to-rank literature, it is implicitly assumed that during the training data generation one has access to the \emph{best or desired} order for the given list of items. In this work, we consider a problem setup where we do not observe the desired ranking. We present two novel solutions: the first solution is an extension of already existing listwise learning-to-rank technique--Listwise maximum likelihood estimation (ListMLE)--while the second one is a generic machine learning based framework that tackles the problem in its entire generality. We discuss several challenges associated with this generic framework, and propose a simple \emph{item-payoff} and \emph{positional-gain} model that addresses these challenges. We provide training algorithms, inference procedures, and demonstrate the effectiveness of the two approaches over traditional ListMLE on synthetic as well as on real-life setting of ranking news articles for increased dwell time.

Twitter provides an open and rich source of data for studying human behaviour at scale and is widely used in social and network sciences. However, a major criticism of Twitter data is that demographic information is largely absent. Enhancing Twitter data with user ages would advance our ability to study social network structures, information flows and the spread of contagions. Approaches toward age detection of Twitter users typically focus on specific properties of tweets, e.g., linguistic features, which are language dependent. In this paper, we devise a language-independent methodology for determining the age of Twitter users from data that is native to the Twitter ecosystem. The key idea is to use a Bayesian framework to generalise ground-truth age information from a few Twitter users to the entire network based on what/whom they follow. Our approach scales to inferring the age of 700 million Twitter accounts with high accuracy.

We analyze the problem of learning a single user's preferences in an active learning setting, sequentially and adaptively querying the user over a finite time horizon. Learning is conducted via choice-based queries, where the user selects her preferred option among a small subset of offered alternatives. These queries have been shown to be a robust and efficient way to learn an individual's preferences. We take a parametric approach and model the user's preferences through a linear classifier, using a Bayesian prior to encode our current knowledge of this classifier. The rate at which we learn depends on the alternatives offered at every time epoch. Under certain noise assumptions, we show that the Bayes-optimal policy for maximally reducing entropy of the posterior distribution of this linear classifier is a greedy policy, and that this policy achieves a linear lower bound when alternatives can be constructed from the continuum. Further, we analyze a different metric called misclassification error, proving that the performance of the optimal policy that minimizes misclassification error is bounded below by a linear function of differential entropy. Lastly, we numerically compare the greedy entropy reduction policy with a knowledge gradient policy under a number of scenarios, examining their performance under both differential entropy and misclassification error.

This post is inspired by a site I found whilst searching for a way to detect sarcasm within sentences. As humans we sometimes struggle detecting sarcasm when we have a lot more contextual information available to us. People are emotive when they speak, they use certain tones and these traits can help us understand when someone is being sarcastic. However we don't always catch it! So how the hell could a computer detect this, when all it has is text.

MOOC Video Collection 777 views Decision Theory: Utility Functions - Stanford University - Duration: 18:16.

Machine learning- to put it mildly- is an incredibly broad and varied field, with multitudes of applications. Thus, writing a list entitled "10 Machine Learning Experts You Need to Know" proves challenging for a number of reasons. Firstly, I've restricted my ten picks to those currently working in the field- if I extended it to those living and passed, I never would have been able to identify only ten worthy of mention. Secondly, this list is in no way ranked- how would I decide which is more remarkable? Third, this is by no means an exhaustive list of people currently making significant contributions to the field of machine learning, or the wider world.

In this paper, we propose PCKID, a novel, robust, kernel function for spectral clustering, specifically designed to handle incomplete data. By combining posterior distributions of Gaussian Mixture Models for incomplete data on different scales, we are able to learn a kernel for incomplete data that does not depend on any critical hyperparameters, unlike the commonly used RBF kernel. To evaluate our method, we perform experiments on two real datasets. PCKID outperforms the baseline methods for all fractions of missing values and in some cases outperforms the baseline methods with up to 25 percentage points.

Nested Chinese Restaurant Process (nCRP) topic models are powerful nonparametric Bayesian methods to extract a topic hierarchy from a given text corpus, where the hierarchical structure is automatically determined by the data. Hierarchical Latent Dirichlet Allocation (hLDA) is a popular instance of nCRP topic models. However, hLDA has only been evaluated at small scale, because the existing collapsed Gibbs sampling and instantiated weight variational inference algorithms either are not scalable or sacrifice inference quality with mean-field assumptions. Moreover, an efficient distributed implementation of the data structures, such as dynamically growing count matrices and trees, is challenging. In this paper, we propose a novel partially collapsed Gibbs sampling (PCGS) algorithm, which combines the advantages of collapsed and instantiated weight algorithms to achieve good scalability as well as high model quality. An initialization strategy is presented to further improve the model quality. Finally, we propose an efficient distributed implementation of PCGS through vectorization, pre-processing, and a careful design of the concurrent data structures and communication strategy. Empirical studies show that our algorithm is 111 times more efficient than the previous open-source implementation for hLDA, with comparable or even better model quality. Our distributed implementation can extract 1,722 topics from a 131-million-document corpus with 28 billion tokens, which is 4-5 orders of magnitude larger than the previous largest corpus, with 50 machines in 7 hours.

A humanoid robot, named Aiko Chihira by its creators at Toshiba and Osaka University, at a 2015 trial in Tokyo's Mitsukoshi department store. Toshiba says it will incorporate speech recognition and synthesis into the robot by 2020. Machines that speak are nothing new. Siri has been answering questions from iPhone users since 2011, and text-to-voice programs have been around even longer. People with speaking disabilities--most famously, Stephen Hawking--have used computers to generate speech for decades.