The goal of Machine Learning to automatically learn from data, extract knowledge and to make decisions without any human intervention. Such automatic (aML) approaches show impressive success. Recent results even demonstrate intriguingly that deep learning applied for automatic classification of skin lesions is on par with the performance of dermatologists, yet outperforms the average. As human perception is inherently limited, such approaches can discover patterns, e.g. that two objects are similar, in arbitrarily high-dimensional spaces what no human is able to do. Humans can deal only with limited amounts of data, whilst big data is beneficial for aML; however, in health informatics, we are often confronted with a small number of data sets, where aML suffer of insufficient training samples and many problems are computationally hard. Here, interactive machine learning (iML) may be of help, where a human-in-the-loop contributes to reduce the complexity of NP-hard problems. A further motivation for iML is that standard black-box approaches lack transparency, hence do not foster trust and acceptance of ML among end-users. Rising legal and privacy aspects, e.g. with the new European General Data Protection Regulations, make black-box approaches difficult to use, because they often are not able to explain why a decision has been made. In this paper, we present some experiments to demonstrate the effectiveness of the human-in-the-loop approach, particularly in opening the black-box to a glass-box and thus enabling a human directly to interact with an learning algorithm. We selected the Ant Colony Optimization framework, and applied it on the Traveling Salesman Problem, which is a good example, due to its relevance for health informatics, e.g. for the study of protein folding. From studies of how humans extract so much from so little data, fundamental ML-research also may benefit.

We consider structure discovery of undirected graphical models from observational data. Inferring likely structures from few examples is a complex task often requiring the formulation of priors and sophisticated inference procedures. Popular methods rely on estimating a penalized maximum likelihood of the precision matrix. However, in these approaches structure recovery is an indirect consequence of the data-fit term, the penalty can be difficult to adapt for domain-specific knowledge, and the inference is computationally demanding. By contrast, it may be easier to generate training samples of data that arise from graphs with the desired structure properties. We propose here to leverage this latter source of information as training data to learn a function, parametrized by a neural network that maps empirical covariance matrices to estimated graph structures. Learning this function brings two benefits: it implicitly models the desired structure or sparsity properties to form suitable priors, and it can be tailored to the specific problem of edge structure discovery, rather than maximizing data likelihood. Applying this framework, we find our learnable graph-discovery method trained on synthetic data generalizes well: identifying relevant edges in both synthetic and real data, completely unknown at training time. We find that on genetics, brain imaging, and simulation data we obtain performance generally superior to analytical methods.

In Bayesian statistics, probabilities are interpreted as degrees of belief. For any set of mutually exclusive and exhaustive events, one expresses the state of knowledge as a probability distribution over that set. The probability of an event then describes the personal confidence that this event will happen or has happened. As a consequence, probabilities are subjective properties reflecting the amount of knowledge an observer has about the events; a different observer might know which event happened and assign different probabilities. If an observer gains information, she updates the probabilities she had assigned before. If the set of possible mutually exclusive and exhaustive events is infinite, it is generally impossible to store all entries of the corresponding probability distribution on a computer or communicate it through a channel with finite bandwidth. One therefore needs to approximate the probability distribution which describes one's belief. Given a limited set X of approximative beliefs q(s) on a quantity s, what is the best belief to approximate the actual belief as expressed by the probability p(s)? In the literature, it is sometimes claimed that the best approximation is given by the q X that minimizes the Kullback-Leibler divergence ("approximation" KL) [1] KL(p, q) () p(s) p(s) ln (1) q(s)

Latent tree models are graphical models defined on trees, in which only a subset of variables is observed. They were first discussed by Judea Pearl as tree-decomposable distributions to generalise star-decomposable distributions such as the latent class model. Latent tree models, or their submodels, are widely used in: phylogenetic analysis, network tomography, computer vision, causal modeling, and data clustering. They also contain other well-known classes of models like hidden Markov models, Brownian motion tree model, the Ising model on a tree, and many popular models used in phylogenetics. We offer here a concise introduction to the theory of latent tree models. We emphasise the role of tree metrics in the structural description of this model class, in designing learning algorithms, and in understanding fundamental limits of what and when can be learned. We present Gaussian and general Markov models as subclasses of latent tree models that admits tractable and rigorous analysis. A leaf of T is a vertex of degree one, an internal vertex is a vertex which is not a leaf, and an inner edge is an edge whose both ends are internal vertices. Given a treeT define a rooted tree as a directed graph obtained from T by picking one of its verticesr and directing all edges away fromr . The vertexr is called the root. Trees will be always leaf-labeled with the labelling set{ 1,...,m}, where m is the number of leaves. An undirected tree is trivalent if each internal vertex has degree precisely three. A rooted tree is a binary rooted tree if each internal vertex has precisely two children. In many applications rooted trees are depicted without using arrows, where direction is made implicit by drawing the root on the top and the leaves on the bottom; see Figure 1(c). Two special types of undirected trees are: a star tree with one internal vertex and a trivalent tree on four leaves called a quartet tree; see Figure 1(a) and (b). A forest is a collection of trees. Forests here are also leaf-labeled with the labelling set is{ 1,...,m}, which means that each tree in this collection is leaf-labeled and the corresponding collection of labelling sets forms a set partition of { 1,...,m}. We define three graph operations on trees (forests). Removing an edge means removing that edge from the edge set. Contracting an edge u v means removingu,v from the vertex set, adding a new vertexw and edges such thatw is adjacent to all vertices which were adjacent tou or v. Suppressing a vertex of degree two means removing that vertex and replacing the two edges incident to that vertex by a single edge. 1 2 3 4 5 1 2 3 4 (a) (b) (c) Figure 1: (a) An undirected star tree with five leaves, (b) a quartet tree, (c) a binary rooted tree.

In the last few months, I have had several people contact me about their enthusiasm for venturing into the world of data science and using Machine Learning (ML) techniques to probe statistical regularities and build impeccable data-driven products. However, I've observed that some actually lack the necessary mathematical intuition and framework to get useful results. This is the main reason I decided to write this blog post. Recently, there has been an upsurge in the availability of many easy-to-use machine and deep learning packages such as scikit-learn, Weka, Tensorflow etc. Machine Learning theory is a field that intersects statistical, probabilistic, computer science and algorithmic aspects arising from learning iteratively from data and finding hidden insights which can be used to build intelligent applications. Despite the immense possibilities of Machine and Deep Learning, a thorough mathematical understanding of many of these techniques is necessary for a good grasp of the inner workings of the algorithms and getting good results. There are many reasons why the mathematics of Machine Learning is important and I'll highlight some of them below: The main question when trying to understand an interdisciplinary field such as Machine Learning is the amount of maths necessary and the level of maths needed to understand these techniques.

The simplest solutions are usually the most powerful ones, and Naive Bayes is a good proof of that. In spite of the great advances of the Machine Learning in the last years, it has proven to not only be simple but also fast, accurate and reliable. It has been successfully used for many purposes, but it works particularly well with natural language processing (NLP) problems. Naive Bayes is a family of probabilistic algorithms that take advantage of probability theory and Bayes' Theorem to predict the category of a sample (like a piece of news or a customer review). They are probabilistic, which means that they calculate the probability of each category for a given sample, and then output the category with the highest one.

We consider the multi armed bandit problem in non-stationary environments. Based on the Bayesian method, we propose a variant of Thompson Sampling which can be used in both rested and restless bandit scenarios. Applying discounting to the parameters of prior distribution, we describe a way to systematically reduce the effect of past observations. Further, we derive the exact expression for the probability of picking sub-optimal arms. By increasing the exploitative value of Bayes' samples, we also provide an optimistic version of the algorithm. Extensive empirical analysis is conducted under various scenarios to validate the utility of proposed algorithms. A comparison study with various state-of-the-arm algorithms is also included.

The combination of argumentation and probability paves the way to new accounts of qualitative and quantitative uncertainty, thereby offering new theoretical and applicative opportunities. Due to a variety of interests, probabilistic argumentation is approached in the literature with different frameworks, pertaining to structured and abstract argumentation, and with respect to diverse types of uncertainty, in particular the uncertainty on the credibility of the premises, the uncertainty about which arguments to consider, and the uncertainty on the acceptance status of arguments or statements. Towards a general framework for probabilistic argumentation, we investigate a labelling-oriented framework encompassing a basic setting for rule-based argumentation and its (semi-) abstract account, along with diverse types of uncertainty. Our framework provides a systematic treatment of various kinds of uncertainty and of their relationships and allows us to retrieve (by derivation) multiple statements (sometimes assumed) or results from the literature.

Pretty much all of the common statistical models we use, with the exception of OLS Linear Models, use Maximum Likelihood estimation. If you've ever learned any of these, you've heard that some of the statistics that compare model fit in competing models require that models be nested (specifically, the likelihood ratio test, based on model deviance). This is particularly important while you're trying to do model building. You need to know which model fits better. This can get really confusing because we often talk about variables being nested.

In this paper, a generalized multivariate Student-t mixture model is developed for classification and clustering of Low Probability of Intercept radar waveforms. A Low Probability of Intercept radar signal is characterized by a pulse compression waveform which is either frequency-modulated or phase-modulated. The proposed model can classify and cluster different modulation types such as linear frequency modulation, non linear frequency modulation, polyphase Barker, polyphase P1, P2, P3, P4, Frank and Zadoff codes. The classification method focuses on the introduction of a new prior distribution for the model hyper-parameters that gives us the possibility to handle sensitivity of mixture models to initialization and to allow a less restrictive modeling of data. Inference is processed through a Variational Bayes method and a Bayesian treatment is adopted for model learning, supervised classification and clustering. Moreover, the novel prior distribution is not a well-known probability distribution and both deterministic and stochastic methods are employed to estimate its expectations. Some numerical experiments show that the proposed method is less sensitive to initialization and provides more accurate results than the previous state of the art mixture models.