Clinical researchers use disease progression modeling algorithms to predict future patient status and characterize progression patterns. One approach for disease progression modeling is to describe patient status using a small number of states that represent distinctive distributions over a set of observed measures. Hidden Markov models (HMMs) and its variants are a class of models that both discover these states and make predictions concerning future states for new patients. HMMs can be trained using longitudinal observations of subjects from large-scale cohort studies, clinical trials, and electronic health records. Despite the advantages of using the algorithms for discovering interesting patterns, it still remains challenging for medical experts to interpret model outputs, complex modeling parameters, and clinically make sense of the patterns. To tackle this problem, we conducted a design study with physician scientists, statisticians, and visualization experts, with the goal to investigate disease progression pathways of certain chronic diseases, namely type 1 diabetes (T1D), Huntington's disease, Parkinson's disease, and chronic obstructive pulmonary disease (COPD). As a result, we introduce DPVis which seamlessly integrates model parameters and outcomes of HMMs into interpretable, and interactive visualizations. In this study, we demonstrate that DPVis is successful in evaluating disease progression models, visually summarizing disease states, interactively exploring disease progression patterns, and designing and comparing clinically relevant subgroup cohorts by introducing a case study on observation data from clinical studies of T1D.

Many expensive black-box optimisation problems are sensitive to their inputs. In these problems it makes more sense to locate a region of good designs, than a single, possible fragile, optimal design. Expensive black-box functions can be optimised effectively with Bayesian optimisation, where a Gaussian process is a popular choice as a prior over the expensive function. We propose a method for robust optimisation using Bayesian optimisation to find a region of design space in which the expensive function's performance is insensitive to the inputs whilst retaining a good quality. This is achieved by sampling realisations from a Gaussian process modelling the expensive function and evaluating the improvement for each realisation. The expectation of these improvements can be optimised cheaply with an evolutionary algorithm to determine the next location at which to evaluate the expensive function. We describe an efficient process to locate the optimum expected improvement. We show empirically that evaluating the expensive function at the location in the candidate sweet spot about which the model is most uncertain or at random yield the best convergence in contrast to exploitative schemes. We illustrate our method on six test functions in two, five, and ten dimensions, and demonstrate that it is able to outperform a state-of-the-art approach from the literature.

Safe autonomous driving in urban areas requires robust algorithms to avoid collisions with other traffic participants with limited perception ability. Current deployed approaches relying on Autonomous Emergency Braking (AEB) systems are often overly conservative. In this work, we formulate the problem as a partially observable Markov decision process (POMDP), to derive a policy robust to uncertainty in the pedestrian location. We investigate how to integrate such a policy with an AEB system that operates only when a collision is unavoidable. In addition, we propose a rigorous evaluation methodology on a set of well defined scenarios. We show that combining the two approaches provides a robust autonomous braking system that reduces unnecessary braking caused by using the AEB system on its own.

In recent years, there has been an exponential growth in the number of complex documents and texts that require a deeper understanding of machine learning methods to be able to accurately classify texts in many applications. Many machine learning approaches have achieved surpassing results in natural language processing. The success of these learning algorithms relies on their capacity to understand complex models and non-linear relationships within data. However, finding suitable structures, architectures, and techniques for text classification is a challenge for researchers. In this paper, a brief overview of text classification algorithms is discussed. This overview covers different text feature extractions, dimensionality reduction methods, existing algorithms and techniques, and evaluations methods. Finally, the limitations of each technique and their application in the real-world problem are discussed.

Navigating urban environments represents a complex task for automated vehicles. They must reach their goal safely and efficiently while considering a multitude of traffic participants. We propose a modular decision making algorithm to autonomously navigate intersections, addressing challenges of existing rule-based and reinforcement learning (RL) approaches. We first present a safe RL algorithm relying on a model-checker to ensure safety guarantees. To make the decision strategy robust to perception errors and occlusions, we introduce a belief update technique using a learning based approach. Finally, we use a scene decomposition approach to scale our algorithm to environments with multiple traffic participants. We empirically demonstrate that our algorithm outperforms rule-based methods and reinforcement learning techniques on a complex intersection scenario.

Deception plays a key role in adversarial or strategic interactions for the purpose of self-defence and survival. This paper introduces a general framework and solution to address deception. Most existing approaches for deception consider obfuscating crucial information to rational adversaries with abundant memory and computation resources. In this paper, we consider deceiving adversaries with bounded rationality and in terms of expected rewards. This problem is commonly encountered in many applications especially involving human adversaries. Leveraging the cognitive bias of humans in reward evaluation under stochastic outcomes, we introduce a framework to optimally assign resources of a limited quantity to optimally defend against human adversaries. Modeling such cognitive biases follows the so-called prospect theory from behavioral psychology literature. Then we formulate the resource allocation problem as a signomial program to minimize the defender's cost in an environment modeled as a Markov decision process. We use police patrol hour assignment as an illustrative example and provide detailed simulation results based on real-world data.

Data driven soft sensor design has recently gained immense popularity, due to advances in sensory devices, and a growing interest in data mining. While partial least squares (PLS) is traditionally used in the process literature for designing soft sensors, the statistical literature has focused on sparse learners, such as Lasso and relevance vector machine (RVM), to solve the high dimensional data problem. In the current study, predictive performances of three regression techniques, PLS, Lasso and RVM were assessed and compared under various offline and online soft sensing scenarios applied on datasets from five real industrial plants, and a simulated process. In offline learning, predictions of RVM and Lasso were found to be superior to those of PLS when a large number of time-lagged predictors were used. Online prediction results gave a slightly more complicated picture. It was found that the minimum prediction error achieved by PLS under moving window (MW), or just-in-time learning scheme was decreased up to ~5-10% using Lasso, or RVM. However, when a small MW size was used, or the optimum number of PLS components was as low as ~1, prediction performance of PLS surpassed RVM, which was found to yield occasional unstable predictions. PLS and Lasso models constructed via online parameter tuning generally did not yield better predictions compared to those constructed via offline tuning. We present evidence to suggest that retaining a large portion of the available process measurement data in the predictor matrix, instead of preselecting variables, would be more advantageous for sparse learners in increasing prediction accuracy. As a result, Lasso is recommended as a better substitute for PLS in soft sensors; while performance of RVM should be validated before online application.

Since the advent of the horseshoe priors for regularization, global-local shrinkage methods have proved to be a fertile ground for the development of Bayesian methodology in machine learning, specifically for high-dimensional regression and classification problems. They have achieved remarkable success in computation, and enjoy strong theoretical support. Most of the existing literature has focused on the linear Gaussian case; see Bhadra et al. (2019) for a systematic survey. The purpose of the current article is to demonstrate that the horseshoe regularization is useful far more broadly, by reviewing both methodological and computational developments in complex models that are more relevant to machine learning applications. Specifically, we focus on methodological challenges in horseshoe regularization in nonlinear and non-Gaussian models; multivariate models; and deep neural networks. We also outline the recent computational developments in horseshoe shrinkage for complex models along with a list of available software implementations that allows one to venture out beyond the comfort zone of the canonical linear regression problems.

Structure learning of Bayesian networks has always been a challenging problem. Nowadays, massive-size networks with thousands or more of nodes but fewer samples frequently appear in many areas. We develop a divide-and-conquer framework, called partition-estimation-fusion (PEF), for structure learning of such big networks. The proposed method first partitions nodes into clusters, then learns a subgraph on each cluster of nodes, and finally fuses all learned subgraphs into one Bayesian network. The PEF method is designed in a flexible way so that any structure learning method may be used in the second step to learn a subgraph structure as either a DAG or a CPDAG. In the clustering step, we adapt the hierarchical clustering method to automatically choose a proper number of clusters. In the fusion step, we propose a novel hybrid method that sequentially add edges between subgraphs. Extensive numerical experiments demonstrate the competitive performance of our PEF method, in terms of both speed and accuracy compared to existing methods. Our method can improve the accuracy of structure learning by 20% or more, while reducing running time up to two orders-of-magnitude.

Graph structured data are abundant in the real world. Among different graph types, directed acyclic graphs (DAGs) are of particular interests to machine learning researchers, as many machine learning models are realized as computations on DAGs, including neural networks and Bayesian networks. In this paper, we study deep generative models for DAGs, and propose a novel DAG variational autoencoder (D-VAE). To encode DAGs into the latent space, we leverage graph neural networks. We propose a DAG-style asynchronous message passing scheme that allows encoding the computations defined by DAGs, rather than using existing simultaneous message passing schemes to encode the graph structures. We demonstrate the effectiveness of our proposed D-VAE through two tasks: neural architecture search and Bayesian network structure learning. Experiments show that our model not only generates novel and valid DAGs, but also produces a smooth latent space that facilitates searching for DAGs with better performance through Bayesian optimization.