Automatic segmentation methods based on deep learning have recently demonstrated state-of-the-art performance, outperforming the ordinary methods. Nevertheless, these methods are inapplicable for small datasets, which are very common in medical problems. To this end, we propose a knowledge transfer method between diseases via the Generative Bayesian Prior network. Our approach is compared to a pre-train approach and random initialization and obtains the best results in terms of Dice Similarity Coefficient metric for the small subsets of the Brain Tumor Segmentation 2018 database (BRATS2018).

This paper focuses on "tracing player knowledge" in educational games. Specifically, given a set of concepts or skills required to master a game, the goal is to estimate the likelihood with which the current player has mastery of each of those concepts or skills. The main contribution of the paper is an approach that integrates machine learning and domain knowledge rules to find when the player applied a certain skill and either succeeded or failed. This is then given as input to a standard knowledge tracing module (such as those from Intelligent Tutoring Systems) to perform knowledge tracing. We evaluate our approach in the context of an educational game called "Parallel" to teach parallel and concurrent programming with data collected from real users, showing our approach can predict students skills with a low mean-squared error.

--Melody generation from lyrics has been a challenging research issue in the field of artificial intelligence and music, which enables to learn and discover latent relationship between interesting lyrics and accompanying melody. Unfortunately, the limited availability of paired lyrics-melody dataset with alignment information has hindered the research progress. T o address this problem, we create a large dataset consisting of 12,197 MIDI songs each with paired lyrics and melody alignment through leveraging different music sources where alignment relationship between syllables and music attributes is extracted. Most importantly, we propose a novel deep generative model, conditional Long Short-T erm Memory - Generative Adversarial Network (LSTM-GAN) for melody generation from lyrics, which contains a deep LSTM generator and a deep LSTM discriminator both conditioned on lyrics. In particular, lyrics-conditioned melody and alignment relationship between syllables of given lyrics and notes of predicted melody are generated simultaneously. Experimental results have proved the effectiveness of our proposed lyrics-to-melody generative model, where plausible and tuneful sequences can be inferred from lyrics. I NTRODUCTION Music generation is also referred to as music composition with the process of creating or writing an original piece of music, which is one of human creative activities [1]. Without understanding music rules and concepts well, creating pleasing sounds is impossible. To learn these kinds of rules and concepts such as mathematical relationships between notes, timing, and melody, the earliest study of various music computational techniques related to Artificial Intelligence (AI) has emerged for music composition in the middle of 1950s [2]. Markov models as a representative method of machine learning have been applied to algorithmic composition [3]. However, due to the limited availability of paired lyrics-melody dataset with alignment information, research progress of lyrics-conditioned music generation has been obstructed.

Multimodal learning aims to discover the relationship between multiple modalities. It has become an important research topic due to extensive multimodal applications such as cross-modal retrieval. This paper attempts to address the modality heterogeneity problem based on Gaussian process latent variable models (GPLVMs) to represent multimodal data in a common space. Previous multimodal GPLVM extensions generally adopt individual learning schemes on latent representations and kernel hyperparameters, which ignore their intrinsic relationship. To exploit strong complementarity among different modalities and GPLVM components, we develop a novel learning scheme called Harmonization, where latent model parameters are jointly learned from each other. Beyond the correlation fitting or intra-modal structure preservation paradigms widely used in existing studies, the harmonization is derived in a model-driven manner to encourage the agreement between modality-specific GP kernels and the similarity of latent representations. We present a range of multimodal learning models by incorporating the harmonization mechanism into several representative GPLVM-based approaches. Experimental results on four benchmark datasets show that the proposed models outperform the strong baselines for cross-modal retrieval tasks, and that the harmonized multimodal learning method is superior in discovering semantically consistent latent representation.

Activity and motion analysis has the potential to be used as a diagnostic tool for mental disorders. However, to-date, little work has been performed in turning stratification measures of activity into useful symptom markers. The research presented in this thesis has focused on the identification of objective activity and behaviour metrics that could be useful for the analysis of mental health symptoms in the above mentioned dimensions. Particular attention is given to the analysis of objective differences between disorders, as well as identification of clinical episodes of mania and depression in bipolar patients, and deterioration in borderline personality disorder patients. A principled framework is proposed for mHealth monitoring of psychiatric patients, based on measurable changes in behaviour, represented in physical activity time series, collected via mobile and wearable devices. The framework defines methods for direct computational analysis of symptoms in disorganisation and psychomotor dimensions, as well as measures for indirect assessment of mood, using patterns of physical activity, sleep and circadian rhythms. The approach of computational behaviour analysis, proposed in this thesis, has the potential for early identification of clinical deterioration in ambulatory patients, and allows for the specification of distinct and measurable behavioural phenotypes, thus enabling better understanding and treatment of mental disorders.

A computer code can simulate a system's propagation of variation from random inputs to output measures of quality. Our aim here is to estimate a critical output tail probability or quantile without a large Monte Carlo experiment. Instead, we build a statistical surrogate for the input-output relationship with a modest number of evaluations and then sequentially add further runs, guided by a criterion to improve the estimate. We compare two criteria in the literature. Moreover, we investigate two practical questions: how to design the initial code runs and how to model the input distribution. Hence, we close the gap between the theory of sequential design and its application.

Multiple seasonal patterns play a key role in time series forecasting, especially for business time series where seasonal effects are often dramatic. Previous approaches including Fourier decomposition, exponential smoothing, and seasonal autoregressive integrated moving average (SARIMA) models do not reflect the distinct characteristics of each period in seasonal patterns, such as the unique behavior of specific days of the week in business data. We propose a multi-dimensional hierarchical model. Intermediate parameters for each seasonal period are first estimated, and a mixture of intermediate parameters is then taken, resulting in a model that successfully reflects the interactions between multiple seasonal patterns. Although this process reduces the data available for each parameter, a robust estimation can be obtained through a hierarchical Bayesian model implemented in Stan. Through this model, it becomes possible to consider both the characteristics of each seasonal period and the interactions among characteristics from multiple seasonal periods. Our new model achieved considerable improvements in prediction accuracy compared to previous models, including Fourier decomposition, which Prophet uses to model seasonality patterns. A comparison was performed on a real-world dataset of pallet transport from a national-scale logistic network.

The worldwide growth of maritime traffic and the development of the Automatic Identification System (AIS) has led to advances in monitoring systems for preventing vessel accidents and detecting illegal activities. In this work, we describe research gaps and challenges in machine learning for vessel behavior change and event detection, considering several constraints imposed by real-time data streams and the maritime monitoring domain. As a starting point, we investigate how unsupervised and semi-supervised change detection methods may be employed for identifying shifts in vessel behavior, aiming to detect and label unusual events.

This study suggests a new approach to EEG data classification by exploring the idea of using evolutionary computation to both select useful discriminative EEG features and optimise the topology of Artificial Neural Networks. An evolutionary algorithm is applied to select the most informative features from an initial set of 2550 EEG statistical features. Optimisation of a Multilayer Perceptron (MLP) is performed with an evolutionary approach before classification to estimate the best hyperparameters of the network. Deep learning and tuning with Long Short-Term Memory (LSTM) are also explored, and Adaptive Boosting of the two types of models is tested for each problem. Three experiments are provided for comparison using different classifiers: one for attention state classification, one for emotional sentiment classification, and a third experiment in which the goal is to guess the number a subject is thinking of. The obtained results show that an Adaptive Boosted LSTM can achieve an accuracy of 84.44%, 97.06%, and 9.94% on the attentional, emotional, and number datasets, respectively. An evolutionary-optimised MLP achieves results close to the Adaptive Boosted LSTM for the two first experiments and significantly higher for the number-guessing experiment with an Adaptive Boosted DEvo MLP reaching 31.35%, while being significantly quicker to train and classify. In particular, the accuracy of the nonboosted DEvo MLP was of 79.81%, 96.11%, and 27.07% in the same benchmarks. Two datasets for the experiments were gathered using a Muse EEG headband with four electrodes corresponding to TP9, AF7, AF8, and TP10 locations of the international EEG placement standard. The EEG MindBigData digits dataset was gathered from the TP9, FP1, FP2, and TP10 locations.

In this work we develop a distributed least squares approximation (DLSA) method, which is able to solve a large family of regression problems (e.g., linear regression, logistic regression, Cox's model) on a distributed system. By approximating the local objective function using a local quadratic form, we are able to obtain a combined estimator by taking a weighted average of local estimators. The resulting estimator is proved to be statistically as efficient as the global estimator. In the meanwhile it requires only one round of communication. We further conduct the shrinkage estimation based on the DLSA estimation by using an adaptive Lasso approach. The solution can be easily obtained by using the LARS algorithm on the master node. It is theoretically shown that the resulting estimator enjoys the oracle property and is selection consistent by using a newly designed distributed Bayesian Information Criterion (DBIC). The finite sample performance as well as the computational efficiency are further illustrated by extensive numerical study and an airline dataset. The airline dataset is 52GB in memory size. The entire methodology has been implemented by Python for a de-facto standard Spark system. By using the proposed DLSA algorithm on the Spark system, it takes 26 minutes to obtain a logistic regression estimator whereas a full likelihood algorithm takes 15 hours to reaches an inferior result.