This thesis focuses on the research and development of the Hemodynamic Tissue Signature (HTS) method: an unsupervised machine learning approach to describe the vascular heterogeneity of glioblastomas by means of perfusion MRI analysis. The HTS builds on the concept of habitats. An habitat is defined as a sub-region of the lesion with a particular MRI profile describing a specific physiological behavior. The HTS method delineates four habitats within the glioblastoma: the High Angiogenic Tumor (HAT) habitat, as the most perfused region of the enhancing tumor; the Low Angiogenic Tumor (LAT) habitat, as the region of the enhancing tumor with a lower angiogenic profile; the potentially Infiltrated Peripheral Edema (IPE) habitat, as the non-enhancing region adjacent to the tumor with elevated perfusion indexes; and the Vasogenic Peripheral Edema (VPE) habitat, as the remaining edema of the lesion with the lowest perfusion profile. The results of this thesis have been published in ten scientific contributions, including top-ranked journals and conferences in the areas of Medical Informatics, Statistics and Probability, Radiology & Nuclear Medicine, Machine Learning and Data Mining and Biomedical Engineering. An industrial patent registered in Spain (ES201431289A), Europe (EP3190542A1) and EEUU (US20170287133A1) was also issued, summarizing the efforts of the thesis to generate tangible assets besides the academic revenue obtained from research publications. Finally, the methods, technologies and original ideas conceived in this thesis led to the foundation of ONCOANALYTICS CDX, a company framed into the business model of companion diagnostics for pharmaceutical compounds, thought as a vehicle to facilitate the industrialization of the ONCOhabitats technology.

Independent sociological polls are forbidden in Belarus. Online polls performed without sound scientific rigour do not yield representative results. Yet, both inside and outside Belarus it is of great importance to obtain precise estimates of the ratings of all candidates. These ratings could function as reliable proxies for the election's outcomes. We conduct an independent poll based on the combination of the data collected via Viber and on the streets of Belarus. The Viber and the street data samples consist of almost 45000 and 1150 unique observations respectively. Bayesian regressions with poststratification were build to estimate ratings of the candidates and rates of early voting turnout for the population as a whole and within various focus subgroups. We show that both the officially announced results of the election and early voting rates are highly improbable. With a probability of at least 95%, Sviatlana Tikhanouskaya's rating lies between 75% and 80%, whereas Aliaksandr Lukashenka's rating lies between 13% and 18% and early voting rate predicted by the method ranges from 9% to 13% of those who took part in the election. These results contradict the officially announced outcomes, which are 10.12%, 80.11%, and 49.54% respectively and lie far outside even the 99.9% credible intervals predicted by our model. The only marginal groups of people where the upper bounds of the 99.9% credible intervals of the rating of Lukashenka are above 50% are people older than 60 and uneducated people. For all other marginal subgroups, including rural residents, even the upper bounds of 99.9% credible intervals for Lukashenka are far below 50%. The same is true for the population as a whole. Thus, with a probability of at least 99.9% Lukashenka could not have had enough electoral support to win the 2020 presidential election in Belarus.

Much recent research has shed light on the development of the relation-dependent but content-independent framework for social spammer detection. This is largely because the relation among users is difficult to be altered when spammers attempt to conceal their malicious intents. Our study investigates the spammer detection problem in the context of multi-relation social networks, and makes an attempt to fully exploit the sequences of heterogeneous relations for enhancing the detection accuracy. Specifically, we present the Multi-level Dependency Model (MDM). The MDM is able to exploit user's long-term dependency hidden in their relational sequences along with short-term dependency. Moreover, MDM fully considers short-term relational sequences from the perspectives of individual-level and union-level, due to the fact that the type of short-term sequences is multi-folds. Experimental results on a real-world multi-relational social network demonstrate the effectiveness of our proposed MDM on multi-relational social spammer detection.

A COVID-19 vaccine is our best bet for mitigating the ongoing onslaught of the pandemic. However, vaccine is also expected to be a limited resource. An optimal allocation strategy, especially in countries with access inequities and a temporal separation of hot-spots might be an effective way of halting the disease spread. We approach this problem by proposing a novel pipeline VacSIM that dovetails Actor-Critic using Kronecker-Factored Trust Region (ACKTR) model into a Contextual Bandits approach for optimizing the distribution of COVID-19 vaccine. Whereas the ACKTR model suggests better actions and rewards, Contextual Bandits allow online modifications that may need to be implemented on a day-to-day basis in the real world scenario. We evaluate this framework against a naive allocation approach of distributing vaccine proportional to the incidence of COVID-19 cases in five different States across India and demonstrate up to 100,000 additional lives potentially saved and a five-fold increase in the efficacy of limiting the spread over a period of 30 days through the VacSIM approach. We also propose novel evaluation strategies including a standard compartmental model based projections and a causality preserving evaluation of our model. Finally, we contribute a new Open-AI environment meant for the vaccine distribution scenario, and open-source VacSIM for wide testing and applications across the globe.

Due to advances in machine learning and artificial intelligence (AI), a new role is emerging for machines as intelligent assistants to radiologists in their clinical workflows. But what systematic clinical thought processes are these machines using? Are they similar enough to those of radiologists to be trusted as assistants? A live demonstration of such a technology was conducted at the 2016 Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA). The demonstration was presented in the form of a question-answering system that took a radiology multiple choice question and a medical image as inputs. The AI system then demonstrated a cognitive workflow, involving text analysis, image analysis, and reasoning, to process the question and generate the most probable answer. A post demonstration survey was made available to the participants who experienced the demo and tested the question answering system. Of the reported 54,037 meeting registrants, 2,927 visited the demonstration booth, 1,991 experienced the demo, and 1,025 completed a post-demonstration survey. In this paper, the methodology of the survey is shown and a summary of its results are presented. The results of the survey show a very high level of receptiveness to cognitive computing technology and artificial intelligence among radiologists.

Recent researches on robotics have shown significant improvement, spanning from algorithms, mechanics to hardware architectures. Robotics, including manipulators, legged robots, drones, and autonomous vehicles, are now widely applied in diverse scenarios. However, the high computation and data complexity of robotic algorithms pose great challenges to its applications. On the one hand, CPU platform is flexible to handle multiple robotic tasks. GPU platform has higher computational capacities and easy-touse development frameworks, so they have been widely adopted in several applications. On the other hand, FPGA-based robotic accelerators are becoming increasingly competitive alternatives, especially in latency-critical and power-limited scenarios. With specialized designed hardware logic and algorithm kernels, FPGA-based accelerators can surpass CPU and GPU in performance and energy efficiency. In this paper, we give an overview of previous work on FPGA-based robotic accelerators covering different stages of the robotic system pipeline. An analysis of software and hardware optimization techniques and main technical issues is presented, along with some commercial and space applications, to serve as a guide for future work. Therefore, the computation and storage complexity, as well as real-time and power constraints of the robotic system, Over the last decade, we have seen significant progress hinders its wide application in latency-critical or power-limited in the development of robotics, spanning from algorithms, scenarios [13]. Various robotic systems, like Therefore, it is essential to choose a proper compute platform manipulators, legged robots, unmanned aerial vehicles, selfdriving for the robotic system. CPU and GPU are two widely cars have been designed for search and rescue [1], [2], used commercial compute platforms. CPU is designed to exploration [3], [4], package delivery [5], entertainment [6], handle a wide range of tasks quickly and is often used to [7] and more applications and scenarios. These robots are develop novel algorithms. A typical CPU can achieve 10-on the rise of demonstrating their full potential. Take drones, 100 GFLOPS with below 1GOP/J power efficiency [14]. In a type of aerial robots, for example, the number of drones contrast, GPU is designed with thousands of processor cores has grown by 2.83x between 2015 and 2019 based on the running simultaneously, which enable massive parallelism. The typical GPU can perform up to 10 TOPS performance and registered number has reached 1.32 million in 2019, and the become a good candidate for high-performance scenarios. Recently, FFA expects this number will come to 1.59 billion by 2024.

With the rapid development in online education, knowledge tracing (KT) has become a fundamental problem which traces students' knowledge status and predicts their performance on new questions. Questions are often numerous in online education systems, and are always associated with much fewer skills. However, the previous literature fails to involve question information together with high-order question-skill correlations, which is mostly limited by data sparsity and multi-skill problems. From the model perspective, previous models can hardly capture the long-term dependency of student exercise history, and cannot model the interactions between student-questions, and student-skills in a consistent way. In this paper, we propose a Graph-based Interaction model for Knowledge Tracing (GIKT) to tackle the above probems. More specifically, GIKT utilizes graph convolutional network (GCN) to substantially incorporate question-skill correlations via embedding propagation. Besides, considering that relevant questions are usually scattered throughout the exercise history, and that question and skill are just different instantiations of knowledge, GIKT generalizes the degree of students' master of the question to the interactions between the student's current state, the student's history related exercises, the target question, and related skills. Experiments on three datasets demonstrate that GIKT achieves the new state-of-the-art performance, with at least 1% absolute AUC improvement.

Plants are fundamentally important to life. Key research areas in plant science include plant species identification, weed classification using hyper spectral images, monitoring plant health and tracing leaf growth, and the semantic interpretation of leaf information. Botanists easily identify plant species by discriminating between the shape of the leaf, tip, base, leaf margin and leaf vein, as well as the texture of the leaf and the arrangement of leaflets of compound leaves. Because of the increasing demand for experts and calls for biodiversity, there is a need for intelligent systems that recognize and characterize leaves so as to scrutinize a particular species, the diseases that affect them, the pattern of leaf growth, and so on. We review several image processing methods in the feature extraction of leaves, given that feature extraction is a crucial technique in computer vision. As computers cannot comprehend images, they are required to be converted into features by individually analysing image shapes, colours, textures and moments. Images that look the same may deviate in terms of geometric and photometric variations. In our study, we also discuss certain machine learning classifiers for an analysis of different species of leaves.

Imitation learning (IL) aims to mimic the behavior of an expert policy in a sequential decision-making problem given only demonstrations. In this paper, we focus on understanding the minimax statistical limits of IL in episodic Markov Decision Processes (MDPs). We first consider the setting where the learner is provided a dataset of $N$ expert trajectories ahead of time, and cannot interact with the MDP. Here, we show that the policy which mimics the expert whenever possible is in expectation $\lesssim \frac{|\mathcal{S}| H^2 \log (N)}{N}$ suboptimal compared to the value of the expert, even when the expert follows an arbitrary stochastic policy. Here $\mathcal{S}$ is the state space, and $H$ is the length of the episode. Furthermore, we establish a suboptimality lower bound of $\gtrsim |\mathcal{S}| H^2 / N$ which applies even if the expert is constrained to be deterministic, or if the learner is allowed to actively query the expert at visited states while interacting with the MDP for $N$ episodes. To our knowledge, this is the first algorithm with suboptimality having no dependence on the number of actions, under no additional assumptions. We then propose a novel algorithm based on minimum-distance functionals in the setting where the transition model is given and the expert is deterministic. The algorithm is suboptimal by $\lesssim \min \{ H \sqrt{|\mathcal{S}| / N} ,\ |\mathcal{S}| H^{3/2} / N \}$, showing that knowledge of transition improves the minimax rate by at least a $\sqrt{H}$ factor.

This paper shows that dropout training in Generalized Linear Models is the minimax solution of a two-player, zero-sum game where an adversarial nature corrupts a statistician's covariates using a multiplicative nonparametric errors-in-variables model. In this game---known as a Distributionally Robust Optimization problem---nature's least favorable distribution is dropout noise, where nature independently deletes entries of the covariate vector with some fixed probability $\delta$. Our decision-theoretic analysis shows that dropout training---the statistician's minimax strategy in the game---indeed provides out-of-sample expected loss guarantees for distributions that arise from multiplicative perturbations of in-sample data. This paper also provides a novel, parallelizable, Unbiased Multi-Level Monte Carlo algorithm to speed-up the implementation of dropout training. Our algorithm has a much smaller computational cost compared to the naive implementation of dropout, provided the number of data points is much smaller than the dimension of the covariate vector.