At the American Society for Microbiology annual meeting this past weekend, microbiologist Nick Loman of the University of Birmingham spoke about the promise and perils of artificial intelligence in biology. Although microbial geneticists such as Loman are beginning to harness the computational power of machine learning to analyze their data, Loman cautions that many scientists have plunged ahead with using AI before really understanding its benefits--and limitations. The Scientist sat down with Loman in San Francisco to chat further. The Scientist: Are there areas in biology where there have been large amounts of enthusiasm for these approaches? And what are some of the reasons for that? Nick Loman: Definitely in this kind of -omics space people are getting excited about machine learning simply because these are data sets with millions, billions, even trillions of data points and there was no alternative way to analyze them.

Preview this course - GET COUPON CODE Have you ever thought about what would happen if you combined the power of machine learning and artificial intelligence with financial engineering? Today, you can stop imagining, and start doing. This course will teach you the core fundamentals of financial engineering, with a machine learning twist. We will cover must-know topics in financial engineering, such as: Exploratory data analysis, significance testing, correlations, alpha and beta Time series analysis, simple moving average, exponentially-weighted moving average Holt-Winters exponential smoothing model Efficient Market Hypothesis Random Walk Hypothesis Time series forecasting ("stock price prediction") Modern portfolio theory Efficient frontier / Markowitz bullet Mean-variance optimization Maximizing the Sharpe ratio Convex optimization with Linear Programming and Quadratic Programming Capital Asset Pricing Model (CAPM) Algorithmic trading (VIP only) Statistical Factor Models (VIP only) Regime Detection with Hidden Markov Models (VIP only) In addition, we will look at various non-traditional techniques which stem purely from the field of machine learning and artificial intelligence, such as: Classification models Unsupervised learning Reinforcement learning and Q-learning ***VIP-only sections (get it while it lasts!) You will learn exactly why their methodology is fundamentally flawed and why their results are complete nonsense.

We propose a framework for deep ordinal regression, based on unimodal output distribution and optimal transport loss. Despite being seemingly appropriate, in many recent works the unimodality requirement is either absent, or implemented using soft targets, which do not guarantee unimodal outputs at inference. In addition, we argue that the standard maximum likelihood objective is not suitable for ordinal regression problems, and that optimal transport is better suited for this task, as it naturally captures the order of the classes. Inspired by the well-known Proportional Odds model, we propose to modify its design by using an architectural mechanism which guarantees that the model output distribution will be unimodal. We empirically analyze the different components of our propose approach and demonstrate their contribution to the performance of the model. Experimental results on three real-world datasets demonstrate that our proposed approach performs on par with several recently proposed deep learning approaches for deep ordinal regression with unimodal output probabilities, while having guarantee on the output unimodality. In addition, we demonstrate that the level of prediction uncertainty of the model correlates with its accuracy.

With growing awareness of societal impact of artificial intelligence, fairness has become an important aspect of machine learning algorithms. The issue is that human biases towards certain groups of population, defined by sensitive features like race and gender, are introduced to the training data through data collection and labeling. Two important directions of fairness ensuring research have focused on (i) instance weighting in order to decrease the impact of more biased instances and (ii) adversarial training in order to construct data representations informative of the target variable, but uninformative of the sensitive attributes. In this paper we propose a Fair Adversarial Instance Re-weighting (FAIR) method, which uses adversarial training to learn instance weighting function that ensures fair predictions. Merging the two paradigms, it inherits desirable properties from both -- interpretability of reweighting and end-to-end trainability of adversarial training. We propose four different variants of the method and, among other things, demonstrate how the method can be cast in a fully probabilistic framework. Additionally, theoretical analysis of FAIR models' properties have been studied extensively. We compare FAIR models to 7 other related and state-of-the-art models and demonstrate that FAIR is able to achieve a better trade-off between accuracy and unfairness. To the best of our knowledge, this is the first model that merges reweighting and adversarial approaches by means of a weighting function that can provide interpretable information about fairness of individual instances.

Noisy labeled data is more a norm than a rarity for crowd sourced contents. It is effective to distill noise and infer correct labels through aggregation results from crowd workers. To ensure the time relevance and overcome slow responses of workers, online label aggregation is increasingly requested, calling for solutions that can incrementally infer true label distribution via subsets of data items. In this paper, we propose a novel online label aggregation framework, BiLA, which employs variational Bayesian inference method and designs a novel stochastic optimization scheme for incremental training. BiLA is flexible to accommodate any generating distribution of labels by the exact computation of its posterior distribution. We also derive the convergence bound of the proposed optimizer. We compare BiLA with the state of the art based on minimax entropy, neural networks and expectation maximization algorithms, on synthetic and real-world data sets. Our evaluation results on various online scenarios show that BiLA can effectively infer the true labels, with an error rate reduction of at least 10 to 1.5 percent points for synthetic and real-world datasets, respectively.

Classification is a prevalent task in machine learning. Churn prediction, spam email detection, image classification are just some common examples. There are many different algorithms that can…

We propose answer-set programs that specify and compute counterfactual interventions as a basis for causality-based explanations to the outcomes from classification models. They can be applied with black-box models, and also with models that can be specified as logic programs, such as rule-based classifiers. The main focus is on the specification and computation of maximum-responsibility counterfactual explanations, with responsibility becoming an explanation score for features of entities under classification. We also extend the programs to bring into the picture semantic or domain knowledge. We show how the approach could be extended by means of probabilistic methods, and how the underlying probability distributions could be modified through the use of constraints.

One of the most challenging aspects of real-world reinforcement learning (RL) is the multitude of unpredictable and ever-changing distractions that could divert an agent from what was tasked to do in its training environment. While an agent could learn from reward signals to ignore them, the complexity of the real-world can make rewards hard to acquire, or, at best, extremely sparse. A recent class of self-supervised methods have shown promise that reward-free adaptation under challenging distractions is possible. However, previous work focused on a short one-episode adaptation setting. In this paper, we consider a long-term adaptation setup that is more akin to the specifics of the real-world and propose a geometric perspective on self-supervised adaptation. We empirically describe the processes that take place in the embedding space during this adaptation process, reveal some of its undesirable effects on performance and show how they can be eliminated. Moreover, we theoretically study how actor-based and actor-free agents can further generalise to the target environment by manipulating the geometry of the manifolds described by the actor and critic functions.

Sparse deep learning aims to address the challenge of huge storage consumption by deep neural networks, and to recover the sparse structure of target functions. Although tremendous empirical successes have been achieved, most sparse deep learning algorithms are lacking of theoretical support. On the other hand, another line of works have proposed theoretical frameworks that are computationally infeasible. In this paper, we train sparse deep neural networks with a fully Bayesian treatment under spike-and-slab priors, and develop a set of computationally efficient variational inferences via continuous relaxation of Bernoulli distribution. The variational posterior contraction rate is provided, which justifies the consistency of the proposed variational Bayes method. Notably, our empirical results demonstrate that this variational procedure provides uncertainty quantification in terms of Bayesian predictive distribution and is also capable to accomplish consistent variable selection by training a sparse multi-layer neural network.

We propose a hierarchical Bayesian recurrent state space model for modeling switching network connectivity in resting state fMRI data. Our model allows us to uncover shared network patterns across disease conditions. We evaluate our method on the ADNI2 dataset by inferring latent state patterns corresponding to altered neural circuits in individuals with Mild Cognitive Impairment (MCI). In addition to states shared across healthy and individuals with MCI, we discover latent states that are predominantly observed in individuals with MCI. Our model outperforms current state of the art deep learning method on ADNI2 dataset.