Diagnosing diseases such as leukemia or anemia requires reliable counts of blood cells. Hematologists usually label and count microscopy images of blood cells manually. In many cases, however, cells in different maturity states are difficult to distinguish, and in combination with image noise and subjectivity, humans are prone to make labeling mistakes. This results in labels that are often not reproducible, which can directly affect the diagnoses. We introduce TIMELY, a probabilistic model that combines pseudotime inference methods with inhomogeneous hidden Markov trees, which addresses this challenge of label inconsistency. We show first on simulation data that TIMELY is able to identify and correct wrong labels with higher precision and recall than baseline methods for labeling correction. We then apply our method to two real-world datasets of blood cell data and show that TIMELY successfully finds inconsistent labels, thereby improving the quality of human-generated labels.

Convolutional Neural Networks (CNN) possess many positive qualities when it comes to spatial raster data. Translation invariance enables CNNs to detect features regardless of their position in the scene. However, in some domains, like geospatial, not all locations are exactly equal. In this work, we propose localized convolutional neural networks that enable convolutional architectures to learn local features in addition to the global ones. We investigate their instantiations in the form of learnable inputs, local weights, and a more general form. They can be added to any convolutional layers, easily end-to-end trained, introduce minimal additional complexity, and let CNNs retain most of their benefits to the extent that they are needed. In this work we address spatio-temporal prediction: test the effectiveness of our methods on a synthetic benchmark dataset and tackle three real-world wind prediction datasets. For one of them, we propose a method to spatially order the unordered data. We compare the recent state-of-the-art spatio-temporal prediction models on the same data. Models that use convolutional layers can be and are extended with our localizations. In all these cases our extensions improve the results, and thus often the state-of-the-art. We share all the code at a public repository.

We train an agent to navigate in 3D environments using a hierarchical strategy including a high-level graph based planner and a local policy. Our main contribution is a data driven learning based approach for planning under uncertainty in topological maps, requiring an estimate of shortest paths in valued graphs with a probabilistic structure. Whereas classical symbolic algorithms achieve optimal results on noise-less topologies, or optimal results in a probabilistic sense on graphs with probabilistic structure, we aim to show that machine learning can overcome missing information in the graph by taking into account rich high-dimensional node features, for instance visual information available at each location of the map. Compared to purely learned neural white box algorithms, we structure our neural model with an inductive bias for dynamic programming based shortest path algorithms, and we show that a particular parameterization of our neural model corresponds to the Bellman-Ford algorithm. By performing an empirical analysis of our method in simulated photo-realistic 3D environments, we demonstrate that the inclusion of visual features in the learned neural planner outperforms classical symbolic solutions for graph based planning.

The Apperception Engine is an unsupervised learning system. Given a sequence of sensory inputs, it constructs a symbolic causal theory that both explains the sensory sequence and also satisfies a set of unity conditions. The unity conditions insist that the constituents of the theory - objects, properties, and laws - must be integrated into a coherent whole. Once a theory has been constructed, it can be applied to predict future sensor readings, retrodict earlier readings, or impute missing readings. In this paper, we evaluate the Apperception Engine in a diverse variety of domains, including cellular automata, rhythms and simple nursery tunes, multi-modal binding problems, occlusion tasks, and sequence induction intelligence tests. In each domain, we test our engine's ability to predict future sensor values, retrodict earlier sensor values, and impute missing sensory data. The engine performs well in all these domains, significantly outperforming neural net baselines and state of the art inductive logic programming systems. These results are significant because neural nets typically struggle to solve the binding problem (where information from different modalities must somehow be combined together into different aspects of one unified object) and fail to solve occlusion tasks (in which objects are sometimes visible and sometimes obscured from view). We note in particular that in the sequence induction intelligence tests, our system achieved human-level performance. This is notable because our system is not a bespoke system designed specifically to solve intelligence tests, but a general-purpose system that was designed to make sense of any sensory sequence.

Smart FinTech has emerged as a new area that synthesizes and transforms AI and finance, and broadly data science, machine learning, economics, etc. Smart FinTech also transforms and drives new economic and financial businesses, services and systems, and plays an increasingly important role in economy, technology and society transformation. This article presents a highly summarized research overview of smart FinTech, including FinTech businesses and challenges, various FinTech-associated data and repositories, FinTech-driven business decision and optimization, areas in smart FinTech, and research methods and techniques for smart FinTech.

In this work, we propose KeRNS: an algorithm for episodic reinforcement learning in non-stationary Markov Decision Processes (MDPs) whose state-action set is endowed with a metric. Using a non-parametric model of the MDP built with time-dependent kernels, we prove a regret bound that scales with the covering dimension of the state-action space and the total variation of the MDP with time, which quantifies its level of non-stationarity. Our method generalizes previous approaches based on sliding windows and exponential discounting used to handle changing environments. We further propose a practical implementation of KeRNS, we analyze its regret and validate it experimentally.

This article explores the use of machine learning models to build a market generator. The underlying idea is to simulate artificial multi-dimensional financial time series, whose statistical properties are the same as those observed in the financial markets. In particular, these synthetic data must preserve the probability distribution of asset returns, the stochastic dependence between the different assets and the autocorrelation across time. The article proposes then a new approach for estimating the probability distribution of backtest statistics. The final objective is to develop a framework for improving the risk management of quantitative investment strategies, in particular in the space of smart beta, factor investing and alternative risk premia.

Restricted Boltzmann machines (RBMs) with low-precision synapses are much appealing with high energy efficiency. However, training RBMs with binary synapses is challenging due to the discrete nature of synapses. Recently Huang proposed one efficient method to train RBMs with binary synapses by using a combination of gradient ascent and the message passing algorithm under the variational inference framework. However, additional heuristic clipping operation is needed. In this technical note, inspired from Huang's work , we propose one alternative optimization method using the Bayesian learning rule, which is one natural gradient variational inference method. As opposed to Huang's method, we update the natural parameters of the variational symmetric Bernoulli distribution rather than the expectation parameters. Since the natural parameters take values in the entire real domain, no additional clipping is needed. Interestingly, the algorithm in \cite{huang2019data} could be viewed as one first-order approximation of the proposed algorithm, which justifies its efficacy with heuristic clipping.

Deep reinforcement learning has been successfully applied to many control tasks, but the application of such controllers in safetycritical scenarios has been limited due to safety concerns. Rigorous testing of these controllers is challenging, particularly when they operate in probabilistic environments due to, for example, hardware faults or noisy sensors. We propose MOSAIC, an algorithm for measuring the safety of deep reinforcement learning controllers in stochastic settings. Our approach is based on the iterative construction of a formal abstraction of a controller's execution in an environment, and leverages probabilistic model checking of Markov decision processes to produce probabilistic guarantees on safe behaviour over a finite time horizon. It produces bounds on the probability of safe operation of the controller for different initial configurations and identifies regions where correct behaviour can be guaranteed. We implement and evaluate our approach on controllers trained for several benchmark control problems.

Ideal point estimation and dimensionality reduction have long been utilized to simplify and cluster complex, high-dimensional political data (e.g., roll-call votes and surveys) for use in analysis and visualization. These methods often work by finding the directions or principal components (PCs) on which either the data varies the most or respondents make the fewest decision errors. However, these PCs, which usually reflect the left-right political spectrum, are sometimes uninformative in explaining significant differences in the distribution of the data (e.g., how to categorize a set of highly-moderate voters). To tackle this issue, we adopt an emerging analysis approach, called contrastive learning. Contrastive learning-e.g., contrastive principal component analysis (cPCA)-works by first splitting the data by predefined groups, and then deriving PCs on which the target group varies the most but the background group varies the least. As a result, cPCA can often find `hidden' patterns, such as subgroups within the target group, which PCA cannot reveal when some variables are the dominant source of variations across the groups. We contribute to the field of contrastive learning by extending it to multiple correspondence analysis (MCA) to enable an analysis of data often encountered by social scientists---namely binary, ordinal, and nominal variables. We demonstrate the utility of contrastive MCA (cMCA) by analyzing three different surveys: The 2015 Cooperative Congressional Election Study, 2012 UTokyo-Asahi Elite Survey, and 2018 European Social Survey. Our results suggest that, first, for the cases when ordinary MCA depicts differences between groups, cMCA can further identify characteristics that divide the target group; second, for the cases when MCA does not show clear differences, cMCA can successfully identify meaningful directions and subgroups, which traditional methods overlook.