Human genes are not continuous but rather consist of short coding regions (exons) interspersed with highly variable non-coding regions (introns). We apply HMMs to the problem of modeling exons, introns and detecting splice sites in the human genome. Our most interesting result so far is the detection of particular oscillatory patterns, with a minimal period ofroughly 10 nucleotides, that seem to be characteristic of exon regions and may have significant biological implications.

Online cursive handwriting recognition is currently one of the most intriguing challenges in pattern recognition. This study presents a novel approach to this problem which is composed of two complementary phases. The first is dynamic encoding of the writing trajectory into a compact sequence of discrete motor control symbols. In this compact representation we largely remove the redundancy of the script, while preserving most of its intelligible components. In the second phase these control sequences are used to train adaptive probabilistic acyclic automata (PAA) for the important ingredients of the writing trajectories, e.g.

This paper presents a simple algorithm to learn trajectories with a continuous time, continuous activation version of the Boltzmann machine. The algorithm takes advantage of intrinsic Brownian noise in the network to easily compute gradients using entirely local computations. The algorithm may be ideal for parallel hardware implementations. This paper presents a learning algorithm to train continuous stochastic networks to respond with desired trajectories in the output units to environmental input trajectories. This is a task, with potential applications to a variety of problems such as stochastic modeling of neural processes, artificial motor control, and continuous speech recognition.

We introduce a new approach for online recognition of handwritten words written in unconstrained mixed style. The preprocessor performs a word-level normalization by fitting a model of the word structure using the EM algorithm. Words are then coded into low resolution "annotated images" where each pixel contains information about trajectory direction and curvature. The recognizer is a convolution network which can be spatially replicated. From the network output, a hidden Markov model produces word scores. The entire system is globally trained to minimize word-level errors. 1 Introduction Natural handwriting is often a mixture of different "styles", lower case printed, upper case, and cursive.

To control such complex systems it is computationally more efficient to decompose the problem into smaller subtasks, with different control strategies for different operating points. When detailed information about the plant is available, gain scheduling has proven a successful method for designing a global control (Shamma and Athans, 1992). The system is partitioned by choosing several operating points and a linear model for each operating point. A controller is designed for each linear model and a method for interpolating or'scheduling' the gains of the controllers is chosen. The control problem becomes even more challenging when the system to be controlled is non-stationary, and the mode of the system is not explicitly observable.

This paper describes probabilistic methods for novelty detection when using pattern recognition methods for fault monitoring of dynamic systems. The problem of novelty detection is particularly acute when prior knowledge and training data only allow one to construct an incomplete classification model. Allowance must be made in model design so that the classifier will be robust to data generated by classes not included in the training phase. For diagnosis applications one practical approach is to construct both an input density model and a discriminative class model. Using Bayes' rule and prior estimates of the relative likelihood of data of known and unknown origin the resulting classification equations are straightforward.

Spotting tasks require detection of target patterns from a background of richly varied non-target inputs. The performance measure of interest for these tasks, called the figure of merit (FOM), is the detection rate for target patterns when the false alarm rate is in an acceptable range. A new approach to training spotters is presented which computes the FOM gradient for each input pattern and then directly maximizes the FOM using backpropagation. This eliminates the need for thresholds during training. It also uses network resources to model Bayesian a posteriori probability functions accurately only for patterns which have a significant effect on the detection accuracy over the false alarm rate of interest.

We propose a learning algorithm for a variable memory length Markov process. Human communication, whether given as text, handwriting, or speech, has multi characteristic time scales. On short scales it is characterized mostly by the dynamics that generate theprocess, whereas on large scales, more syntactic and semantic informationis carried. For that reason the conventionally used fixed memory Markov models cannot capture effectively the complexity of such structures. On the other hand using long memory modelsuniformly is not practical even for as short memory as four.

We describe the relationship between certain reinforcement learning (RL) methods based on dynamic programming (DP) and a class of unorthodox Monte Carlo methods for solving systems of linear equations proposed in the 1950's. These methods recast the solution of the linear system as the expected value of a statistic suitably defined over sample paths of a Markov chain. The significance of our observations lies in arguments (Curtiss, 1954) that these Monte Carlo methods scale better with respect to state-space size than do standard, iterative techniques for solving systems of linear equations. This analysis also establishes convergence rate estimates. Because methods used in RL systems for approximating the evaluation function of a fixed control policy also approximate solutions to systems of linear equations, the connection to these Monte Carlo methods establishes that algorithms very similar to TD algorithms (Sutton, 1988) are asymptotically more efficient in a precise sense than other methods for evaluating policies. Further, all DPbased RL methods have some of the properties of these Monte Carlo algorithms, that although RL is often perceived towhich suggests be slow, for sufficiently large problems, it may in fact be more efficient than other known classes of methods capable of producing the same results.

Several factors Chapter 2 describes a small fragment Chapters 8, 9, and 10 describe have led to the increase in interest in of probability and information recent research on more isolated this field, which is heavily influenced theory, including brief coverage of aspects of parsing and language analysis.