Machine Learning (ML) is the branch of Artificial Intelligence in which we use algorithms to learn from data provided to make predictions on unseen data. Recently, the demand for Machine Learning engineers has rapidly grown across healthcare, Finance, e-commerce, etc. According to Glassdoor, the median ML Engineer Salary is $131,290 per annum. In 2021, the global ML market was valued at $15.44 billion. It is expected to grow at a significant compound annual growth rate (CAGR) above 38% until 2029.

One of the virtues of the Bayesianapproachto statistical analysisis that it gives an unambiguous definition of what it means for there to be evidence in favor of or against a particular value of a parameter. This is provided by the following principle. Principle of Evidence: if the posterior probability of an event is greater than (less than, equal to) its prior probability, then there is evidence in favor of (against, no evidence either way of) the event being true. This seems like a very simple and intuitively satisfying way of characterizing evidence and it has long been considered to be quite natural and obvious. For example, Popper (1968) The Logic of Scientific Discovery, Appendix ix "If we are asked to give a criterion of the fact that the evidence y supports or corroborates a statement x, the most obvious reply is: that y increases the probability of x." Achinstein (2001) "for a fact e to be evidence that a hypothesis h is true, it is both necessary and sufficient for e to increase h's probability over its prior probability".

Deep Learning (DL) holds great promise in reshaping the healthcare industry owing to its precision, efficiency, and objectivity. However, the brittleness of DL models to noisy and out-of-distribution inputs is ailing their deployment in the clinic. Most models produce point estimates without further information about model uncertainty or confidence. This paper introduces a new Bayesian DL framework for uncertainty quantification in segmentation neural networks: SUPER-Net: trustworthy medical image Segmentation with Uncertainty Propagation in Encoder-decodeR Networks. SUPER-Net analytically propagates, using Taylor series approximations, the first two moments (mean and covariance) of the posterior distribution of the model parameters across the nonlinear layers. In particular, SUPER-Net simultaneously learns the mean and covariance without expensive post-hoc Monte Carlo sampling or model ensembling. The output consists of two simultaneous maps: the segmented image and its pixelwise uncertainty map, which corresponds to the covariance matrix of the predictive distribution. We conduct an extensive evaluation of SUPER-Net on medical image segmentation of Magnetic Resonances Imaging and Computed Tomography scans under various noisy and adversarial conditions. Our experiments on multiple benchmark datasets demonstrate that SUPER-Net is more robust to noise and adversarial attacks than state-of-the-art segmentation models. Moreover, the uncertainty map of the proposed SUPER-Net associates low confidence (or equivalently high uncertainty) to patches in the test input images that are corrupted with noise, artifacts, or adversarial attacks. Perhaps more importantly, the model exhibits the ability of self-assessment of its segmentation decisions, notably when making erroneous predictions due to noise or adversarial examples.

Perception, localization, planning, and control, high-level functions often organized in a so-called pipeline, are amongst the core building blocks of modern autonomous (ground, air, and underwater) vehicle architectures. These functions are increasingly being implemented using learning-enabled components (LECs), i.e., (software) components leveraging knowledge acquisition and learning processes such as deep learning. Providing quantified component-level assurance as part of a wider (dynamic) assurance case can be useful in supporting both pre-operational approval of LECs (e.g., by regulators), and runtime hazard mitigation, e.g., using assurance-based failover configurations. This paper develops a notion of assurance for LECs based on i) identifying the relevant dependability attributes, and ii) quantifying those attributes and the associated uncertainty, using probabilistic techniques. We give a practical grounding for our work using an example from the aviation domain: an autonomous taxiing capability for an unmanned aircraft system (UAS), focusing on the application of LECs as sensors in the perception function. We identify the applicable quantitative measures of assurance, and characterize the associated uncertainty using a non-parametric Bayesian approach, namely Gaussian process regression. We additionally discuss the relevance and contribution of LEC assurance to system-level assurance, the generalizability of our approach, and the associated challenges.

Spatial data are characterized by their spatial dependence, which is often complex, non-linear, and difficult to capture with a single model. Significant levels of model uncertainty -- arising from these characteristics -- cannot be resolved by model selection or simple ensemble methods. We address this issue by proposing a novel methodology that captures spatially varying model uncertainty, which we call Bayesian spatial predictive synthesis. Our proposal is derived by identifying the theoretically best approximate model under reasonable conditions, which is a latent factor spatially varying coefficient model in the Bayesian predictive synthesis framework. We then show that our proposed method produces exact minimax predictive distributions, providing finite sample guarantees. Two MCMC strategies are implemented for full uncertainty quantification, as well as a variational inference strategy for fast point inference. We also extend the estimation strategy for general responses. Through simulation examples and two real data applications, we demonstrate that our proposed spatial Bayesian predictive synthesis outperforms standard spatial models and advanced machine learning methods in terms of predictive accuracy.

Qualitative probabilistic networks (QPNs) combine the conditional independence assumptions of Bayesian networks with the qualitative properties of positive and negative dependence. They formalise various intuitive properties of positive dependence to allow inferences over a large network of variables. However, we will demonstrate in this paper that, due to an incorrect symmetry property, many inferences obtained in non-binary QPNs are not mathematically true. We will provide examples of such incorrect inferences and briefly discuss possible resolutions.

Artificial Intelligence (AI) is a fast-growing area of study that stretching its presence to many business and research domains. Machine learning, deep learning, and natural language processing (NLP) are subsets of AI to tackle different areas of data processing and modelling. This review article presents an overview of AI impact on education outlining with current opportunities. In the education domain, student feedback data is crucial to uncover the merits and demerits of existing services provided to students. AI can assist in identifying the areas of improvement in educational infrastructure, learning management systems, teaching practices and study environment. NLP techniques play a vital role in analyzing student feedback in textual format. This research focuses on existing NLP methodologies and applications that could be adapted to educational domain applications like sentiment annotations, entity annotations, text summarization, and topic modelling. Trends and challenges in adopting NLP in education were reviewed and explored. Contextbased challenges in NLP like sarcasm, domain-specific language, ambiguity, and aspect-based sentiment analysis are explained with existing methodologies to overcome them. Research community approaches to extract the semantic meaning of emoticons and special characters in feedback which conveys user opinion and challenges in adopting NLP in education are explored.

This dissertation focuses on modern causal inference under uncertainty and data restrictions, with applications to neoadjuvant clinical trials, distributed data networks, and robust individualized decision making. In the first project, we propose a method under the principal stratification framework to identify and estimate the average treatment effects on a binary outcome, conditional on the counterfactual status of a post-treatment intermediate response. Under mild assumptions, the treatment effect of interest can be identified. We extend the approach to address censored outcome data. The proposed method is applied to a neoadjuvant clinical trial and its performance is evaluated via simulation studies. In the second project, we propose a tree-based model averaging approach to improve the estimation accuracy of conditional average treatment effects at a target site by leveraging models derived from other potentially heterogeneous sites, without them sharing subject-level data. The performance of this approach is demonstrated by a study of the causal effects of oxygen therapy on hospital survival rates and backed up by comprehensive simulations. In the third project, we propose a robust individualized decision learning framework with sensitive variables to improve the worst-case outcomes of individuals caused by sensitive variables that are unavailable at the time of decision. Unlike most existing work that uses mean-optimal objectives, we propose a robust learning framework by finding a newly defined quantile- or infimum-optimal decision rule. From a causal perspective, we also generalize the classic notion of (average) fairness to conditional fairness for individual subjects. The reliable performance of the proposed method is demonstrated through synthetic experiments and three real-data applications.

Counterfactual explanations utilize feature perturbations to analyze the outcome of an original decision and recommend an actionable recourse. We argue that it is beneficial to provide several alternative explanations rather than a single point solution and propose a probabilistic paradigm to estimate a diverse set of counterfactuals. Specifically, we treat the perturbations as random variables endowed with prior distribution functions. This allows sampling multiple counterfactuals from the posterior density, with the added benefit of incorporating inductive biases, preserving domain specific constraints and quantifying uncertainty in estimates. More importantly, we leverage Bayesian hierarchical modeling to share information across different subgroups of a population, which can both improve robustness and measure fairness. A gradient based sampler with superior convergence characteristics efficiently computes the posterior samples. Experiments across several datasets demonstrate that the counterfactuals estimated using our approach are valid, sparse, diverse and feasible.

Applying deep learning to science is a new trend in recent years which leads DL engineering to become an important problem. Although training data preparation, model architecture design, and model training are the normal processes to build DL models, all of them are complex and costly. Therefore, reusing the open-sourced pre-trained model is a practical way to bypass this hurdle for developers. Given a specific task, developers can collect massive pre-trained deep neural networks from public sources for re-using. However, testing the performance (e.g., accuracy and robustness) of multiple DNNs and recommending which model should be used is challenging regarding the scarcity of labeled data and the demand for domain expertise. In this paper, we propose a labeling-free (LaF) model selection approach to overcome the limitations of labeling efforts for automated model reusing. The main idea is to statistically learn a Bayesian model to infer the models' specialty only based on predicted labels. We evaluate LaF using 9 benchmark datasets including image, text, and source code, and 165 DNNs, considering both the accuracy and robustness of models. The experimental results demonstrate that LaF outperforms the baseline methods by up to 0.74 and 0.53 on Spearman's correlation and Kendall's $\tau$, respectively.