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 Bayesian Learning




Regulator Discovery from Gene Expression Time Series of Malaria Parasites: a Hierachical Approach

Neural Information Processing Systems

We introduce a hierarchical Bayesian model for the discovery of putative regulators from gene expression data only. The hierarchy incorporates the knowledge that there are just a few regulators that by themselves only regulate a handful of genes. This is implemented through a so-called spike-and-slab prior, a mixture of Gaussians with different widths, with mixing weights from a hierarchical Bernoulli model. For efficient inference we implemented expectation propagation. Running the model on a malaria parasite data set, we found four genes with significant homology to transcription factors in an amoebe, one RNA regulator and three genes of unknown function (out of the top ten genes considered).


Convex Relaxations of Latent Variable Training

Neural Information Processing Systems

We investigate a new, convex relaxation of an expectation-maximization (EM) variant that approximates a standard objective while eliminating local minima. First, a cautionary result is presented, showing that any convex relaxation of EM over hidden variables must give trivial results if any dependence on the missing values is retained. Although this appears to be a strong negative outcome, we then demonstrate how the problem can be bypassed by using equivalence relations instead ofvalue assignments over hidden variables. In particular, we develop new algorithms for estimating exponential conditional models that only require equivalence relationinformation over the variable values. This reformulation leads to an exact expression for EM variants in a wide range of problems. We then develop a semidefinite relaxation that yields global training by eliminating local minima.


Expectation Maximization and Posterior Constraints

Neural Information Processing Systems

The expectation maximization (EM) algorithm is a widely used maximum likelihood estimationprocedure for statistical models when the values of some of the variables in the model are not observed. Very often, however, our aim is primarily tofind a model that assigns values to the latent variables that have intended meaning for our data and maximizing expected likelihood only sometimes accomplishes this.Unfortunately, it is typically difficult to add even simple a-priori information about latent variables in graphical models without making the models overly complex or intractable. In this paper, we present an efficient, principled way to inject rich constraints on the posteriors of latent variables into the EM algorithm. Our method can be used to learn tractable graphical models that satisfy additional,otherwise intractable constraints. Focusing on clustering and the alignment problem for statistical machine translation, we show that simple, intuitive posteriorconstraints can greatly improve the performance over standard baselines and be competitive with more complex, intractable models.



Catching Up Faster in Bayesian Model Selection and Model Averaging

Neural Information Processing Systems

Bayesian model averaging, model selection and their approximations such as BIC are generally statistically consistent, but sometimes achieve slower rates of convergence thanother methods such as AIC and leave-one-out cross-validation. On the other hand, these other methods can be inconsistent. We identify the catchup phenomenon as a novel explanation for the slow convergence of Bayesian methods. Basedon this analysis we define the switch-distribution, a modification of the Bayesian model averaging distribution. We prove that in many situations model selection and prediction based on the switch-distribution is both consistent and achieves optimal convergence rates, thereby resolving the AIC-BIC dilemma. The method is practical; we give an efficient algorithm.



Supervised Topic Models

Neural Information Processing Systems

We introduce supervised latent Dirichlet allocation (sLDA), a statistical model of labelled documents. The model accommodates a variety of response types. We derive a maximum-likelihood procedure for parameter estimation, which relies on variational approximations to handle intractable posterior expectations. Prediction problems motivate this research: we use the fitted model to predict response values for new documents. We test sLDA on two real-world problems: movie ratings predicted from reviews, and web page popularity predicted from text descriptions. We illustrate the benefits of sLDA versus modern regularized regression, as well as versus an unsupervised LDA analysis followed by a separate regression.