We propose a novel Bayesian approach to solve stochastic optimization problems that involve finding extrema of noisy, nonlinear functions. Previous work has focused on representing possible functions explicitly, which leads to a two-step procedure of first, doing inference over the function space and second, finding the extrema of these functions. Here we skip the representation step and directly model the distribution over extrema. To this end, we devise a non-parametric conjugate prior based on a kernel regressor. The resulting posterior distribution directly captures the uncertainty over the maximum of the unknown function. We illustrate the effectiveness of our model by optimizing a noisy, high-dimensional, non-convex objective function.

LAGE is a systematic framework developed in Java. The motivation of LAGE is to provide a scalable and parallel solution to reconstruct Gene Regulatory Networks (GRNs) from continuous gene expression data for very large amount of genes. The basic idea of our framework is motivated by the philosophy of divideand-conquer. Specifically, LAGE recursively partitions genes into multiple overlapping communities with much smaller sizes, learns intra-community GRNs respectively before merge them altogether. Besides, the complete information of overlapping communities serves as the byproduct, which could be used to mine meaningful functional modules in biological networks.

The improvement of medical care quality is a significant interest for the future years. The fight against nosocomial infections (NI) in the intensive care units (ICU) is a good example. We will focus on a set of observations which reflect the dynamic aspect of the decision, result of the application of a Medical Decision Support System (MDSS). This system has to make dynamic decision on temporal data. We use dynamic Bayesian network (DBN) to model this dynamic process. It is a temporal reasoning within a real-time environment; we are interested in the Dynamic Decision Support Systems in healthcare domain (MDDSS).

In this paper, we present CrowdSense, an algorithm for estimating the crowd’s majority opinion by querying only a subset of it. CrowdSense works in an online fashion where examples come one at a time and it dynamically samples subsets of labelers based on an exploration/exploitation criterion. The algorithm produces a weighted combination of a subset of the labelers’ votes that approximates the crowd’s opinion. We also present two probabilistic variants of CrowdSense that are based on different assumptions on the joint probability distribution between the labelers’ votes and the majority vote. Our experiments demonstrate that we can reliably approximate the entire crowd’s vote by collecting opinions from a representative subset of the crowd.

We study the mixtures of factorizing probability distributions represented as visible marginal distributions in stochastic layered networks. We take the perspective of kernel transitions of distributions, which gives a unified picture of distributed representations arising from Deep Belief Networks (DBN) and other networks without lateral connections. We describe combinatorial and geometric properties of the set of kernels and products of kernels realizable by DBNs as the network parameters vary. We describe explicit classes of probability distributions, including exponential families, that can be learned by DBNs. We use these submodels to bound the maximal and the expected Kullback-Leibler approximation errors of DBNs from above depending on the number of hidden layers and units that they contain.

In this paper, we focus on computing the prices of secu- rities represented by logical formulas in combinatorial prediction markets when the price function is represented by a Bayesian network. This problem turns out to be a natural extension of the weighted model counting (WMC) problem (Sang, Bearne, and Kautz 2005), which we call generalized weighted model counting (GWMC) problem. In GWMC, we are given a logical formula F and a polynomial-time computable weight function. We are asked to compute the total weight of the valuations that satisfy F. Based on importance sampling, we propose a Monte-Carlo meta-algorithm that has a good theoretical guarantee for formulas in disjunctive normal form (DNF). The meta-algorithm queries an oracle algorithm that computes marginal probabilities in Bayesian networks, and has the following theoretical guarantee. When the weight function can be approximately represented by a Bayesian network for which the oracle algorithm runs in polynomial time, our meta-algorithm becomes a fully polynomial-time randomized approximation scheme (FPRAS).

We consider the problem of evaluating the performance of human contributors for tasks involving answering a series of questions, each of which has a single correct answer. The answers may not be known a priori. We assert that the measure of a contributor’s judgments is the amount by which having these judgments decreases the entropy of our discovering the answer. This quantity is the pointwise mutual information between the judgments and the answer. The expected value of this metric is the mutual information between the contributor and the answer prior, which can be computed using only the prior and the conditional probabil- ities of the contributor’s judgments given a correct answer, without knowing the answers themselves. We also propose using multivariable information measures, such as conditional mutual information, to measure the inter- actions between contributors’ judgments. These metrics have a variety of applications. They can be used as a basis for contributor performance evaluation and incentives. They can be used to measure the efficiency of the judgment collection process. If the collection process allows assignment of contributors to questions, they can also be used to optimize this scheduling.

We propose to improve the accuracy of prediction market forecasts by using Bayesian networks to constrain probabilities among related questions. Prediction markets are already known to increase forecast accuracy compared to single best estimates. Our own flat prediction market substantially beat a baseline linear opinion pool during the first year. One way to improve performance is by expressing relationships among the questions. Elsewhere we describe work on combinatorial markets. Here we show how to use Bayesian networks within a flat market. The general approach is to decompose a target question (hypothesis) into a set of related variables (causal factors and evidence), when the relationship among the variables is known with some confidence. Then the marginal probabilities for the variables in the Bayes net are updated using the market estimates, with the Bayes net enforcing coherence. This paper describes the overall concept, shows the results for a particular model of the potential Greek exit from the European Union, and describes the team’s future research plan.

Scarcity of training data for word sense disambiguation argues for the use of knowledge-based disambiguation methods, which rely on information available in terminological resources. Unfortunately, these resources are not generally optimized to perform word sense disambiguation. On the other hand, there are many examples of ambiguous biomedical words with context in MEDLINE. However, these examples of ambiguity are not labeled with their proper sense. We propose the integration of the UMLS and MEDLINE to create concept profiles which are used to perform knowledge-based word sense disambiguation. Our results show an accuracy of 0.8770 on a biomedical word sense disambiguation data set; this represents a statistically significant improvement over other knowledge-based methods based on the UMLS on this data set.

Gaussian process (GP) predictors are an important component of many Bayesian approaches to machine learning. However, even a straightforward implementation of Gaussian process regression (GPR) requires O(n^2) space and O(n^3) time for a dataset of n examples. Several approximation methods have been proposed, but there is a lack of understanding of the relative merits of the different approximations, and in what situations they are most useful. We recommend assessing the quality of the predictions obtained as a function of the compute time taken, and comparing to standard baselines (e.g., Subset of Data and FITC). We empirically investigate four different approximation algorithms on four different prediction problems, and make our code available to encourage future comparisons.