Neural networks have seen limited use in prediction for high-dimensional data with small sample sizes, because they tend to overfit and require tuning many more hyperparameters than existing off-the-shelf machine learning methods. With small modifications to the network architecture and training procedure, we show that dense neural networks can be a practical data analysis tool in these settings. The proposed method, Ensemble by Averaging Sparse-Input Hierarchical networks (EASIER-net), appropriately prunes the network structure by tuning only two L1-penalty parameters, one that controls the input sparsity and another that controls the number of hidden layers and nodes. The method selects variables from the true support if the irrelevant covariates are only weakly correlated with the response; otherwise, it exhibits a grouping effect, where strongly correlated covariates are selected at similar rates. On a collection of real-world datasets with different sizes, EASIER-net selected network architectures in a data-adaptive manner and achieved higher prediction accuracy than off-the-shelf methods on average.

Motivation: Real-world data often contain measurements with both continuous and discrete values. Despite the availability of many libraries, data sets with mixed data types require intensive pre-processing steps, and it remains a challenge to describe the relationships between variables. The data understanding phase is an important step in the data mining process, however, without making any assumptions on the data, the search space is super-exponential in the number of variables. Methods: We propose graphical hypergeometric networks (HNet), a method to test associations across variables for significance using statistical inference. The aim is to determine a network using only the significant associations in order to shed light on the complex relationships across variables. HNet processes raw unstructured data sets and outputs a network that consists of (partially) directed or undirected edges between the nodes (i.e., variables). To evaluate the accuracy of HNet, we used well known data sets and in addition generated data sets with known ground truth. The performance of HNet is compared to Bayesian structure learning. Results: We demonstrate that HNet showed high accuracy and performance in the detection of node links. In the case of the Alarm data set we can demonstrate on average an MCC score of 0.33 + 0.0002 (P<1x10-6), whereas Bayesian structure learning resulted in an average MCC score of 0.52 + 0.006 (P<1x10-11), and randomly assigning edges resulted in a MCC score of 0.004 + 0.0003 (P=0.49). Conclusions: HNet can process raw unstructured data sets, allows analysis of mixed data types, it easily scales up in number of variables, and allows detailed examination of the detected associations. Availability: https://erdogant.github.io/hnet/

Transfer learning research attempts to make model induction transferable across different domains. This method assumes that specific information regarding to which domain each instance belongs is known. This paper helps to extend the capability of transfer learning for linear regression problems to situations where the domain information is uncertain or unknown; in fact, the framework can be extended to classification problems. For normal datasets, we assume that some latent domain information is available for transfer learning. The instances in each domain can be inferred by different parameters. We obtain this domain information from the distribution of the regression coefficients corresponding to the explanatory variable $x$ as well as the response variable $y$ based on a Dirichlet process, which is more reasonable. As a result, we transfer not only variable $x$ as usual but also variable $y$, which is challenging since the testing data have no response value. Previous work mainly overcomes the problem via pseudo-labelling based on transductive learning, which introduces serious bias. We provide a novel framework for analysing the problem and considering this general situation: the joint distribution of variable $x$ and variable $y$. Furthermore, our method controls the bias well compared with previous work. We perform linear regression on the new feature space that consists of different latent domains and the target domain, which is from the testing data. The experimental results show that the proposed model performs well on real datasets.

Recent advances in biological research have seen the emergence of high-throughput technologies with numerous applications that allow the study of biological mechanisms at an unprecedented depth and scale. A large amount of genomic data is now distributed through consortia like The Cancer Genome Atlas (TCGA), where specific types of biological information on specific type of tissue or cell are available. In cancer research, the challenge is now to perform integrative analyses of high-dimensional multi-omic data with the goal to better understand genomic processes that correlate with cancer outcomes, e.g. elucidate gene networks that discriminate a specific cancer subgroups (cancer sub-typing) or discovering gene networks that overlap across different cancer types (pan-cancer studies). In this paper, we propose a novel mixed graphical model approach to analyze multi-omic data of different types (continuous, discrete and count) and perform model selection by extending the Birth-Death MCMC (BDMCMC) algorithm initially proposed by \citet{stephens2000bayesian} and later developed by \cite{mohammadi2015bayesian}. We compare the performance of our method to the LASSO method and the standard BDMCMC method using simulations and find that our method is superior in terms of both computational efficiency and the accuracy of the model selection results. Finally, an application to the TCGA breast cancer data shows that integrating genomic information at different levels (mutation and expression data) leads to better subtyping of breast cancers.

Large-sample data became prevalent as data acquisition became cheaper and easier. While a large sample size has theoretical advantages for many statistical methods, it presents computational challenges. Sketching, or compression, is a well-studied approach to address these issues in regression settings, but considerably less is known about its performance in classification settings. Here we consider the computational issues due to large sample size within the discriminant analysis framework. We propose a new compression approach for reducing the number of training samples for linear and quadratic discriminant analysis, in contrast to existing compression methods which focus on reducing the number of features. We support our approach with a theoretical bound on the misclassification error rate compared to the Bayes classifier. Empirical studies confirm the significant computational gains of the proposed method and its superior predictive ability compared to random sub-sampling.

Bayesian method is capable of capturing real world uncertainties/incompleteness and properly addressing the over-fitting issue faced by deep neural networks. In recent years, Bayesian Neural Networks (BNNs) have drawn tremendous attentions of AI researchers and proved to be successful in many applications. However, the required high computation complexity makes BNNs difficult to be deployed in computing systems with limited power budget. In this paper, an efficient BNN inference flow is proposed to reduce the computation cost then is evaluated by means of both software and hardware implementations. A feature decomposition and memorization (\texttt{DM}) strategy is utilized to reform the BNN inference flow in a reduced manner. About half of the computations could be eliminated compared to the traditional approach that has been proved by theoretical analysis and software validations. Subsequently, in order to resolve the hardware resource limitations, a memory-friendly computing framework is further deployed to reduce the memory overhead introduced by \texttt{DM} strategy. Finally, we implement our approach in Verilog and synthesise it with 45 $nm$ FreePDK technology. Hardware simulation results on multi-layer BNNs demonstrate that, when compared with the traditional BNN inference method, it provides an energy consumption reduction of 73\% and a 4$\times$ speedup at the expense of 14\% area overhead.

In this paper we propose Policy Synthesis under probabilistic Constraints (PSyCo), a systematic engineering method for synthesizing safe policies under probabilistic constraints with reinforcement learning and Bayesian model checking. As an implementation of PSyCo we introduce Safe Neural Evolutionary Strategies (SNES). SNES leverages Bayesian model checking while learning to adjust the Lagrangian of a constrained optimization problem derived from a PSyCo specification. We empirically evaluate SNES' ability to synthesize feasible policies in settings with formal safety requirements.

Inferring models, predicting the future, and estimating the entropy rate of discrete-time, discrete-event processes is well-worn ground. However, a much broader class of discrete-event processes operates in continuous-time. Here, we provide new methods for inferring, predicting, and estimating them. The methods rely on an extension of Bayesian structural inference that takes advantage of neural network's universal approximation power. Based on experiments with complex synthetic data, the methods are competitive with the state-of-the-art for prediction and entropy-rate estimation.

Generative Adversarial Networks (GANs) is a novel class of deep generative models which has recently gained significant attention. GANs learns complex and high-dimensional distributions implicitly over images, audio, and data. However, there exists major challenges in training of GANs, i.e., mode collapse, non-convergence and instability, due to inappropriate design of network architecture, use of objective function and selection of optimization algorithm. Recently, to address these challenges, several solutions for better design and optimization of GANs have been investigated based on techniques of re-engineered network architectures, new objective functions and alternative optimization algorithms. To the best of our knowledge, there is no existing survey that has particularly focused on broad and systematic developments of these solutions. In this study, we perform a comprehensive survey of the advancements in GANs design and optimization solutions proposed to handle GANs challenges. We first identify key research issues within each design and optimization technique and then propose a new taxonomy to structure solutions by key research issues. In accordance with the taxonomy, we provide a detailed discussion on different GANs variants proposed within each solution and their relationships. Finally, based on the insights gained, we present the promising research directions in this rapidly growing field.

In the variational relevance vector machine, the gamma distribution is representative as a hyperprior over the noise precision of automatic relevance determination prior. Instead of the gamma hyperprior, we propose to use the inverse gamma hyperprior with a shape parameter close to zero and a scale parameter not necessary close to zero. This hyperprior is associated with the concept of a weakly informative prior. The effect of this hyperprior is investigated through regression to non-homogeneous data. Because it is difficult to capture the structure of such data with a single kernel function, we apply the multiple kernel method, in which multiple kernel functions with different widths are arranged for input data. We confirm that the degrees of freedom in a model is controlled by adjusting the scale parameter and keeping the shape parameter close to zero. A candidate for selecting the scale parameter is the predictive information criterion. However the estimated model using this criterion seems to cause over-fitting. This is because the multiple kernel method makes the model a situation where the dimension of the model is larger than the data size. To select an appropriate scale parameter even in such a situation, we also propose an extended prediction information criterion. It is confirmed that a multiple kernel relevance vector regression model with good predictive accuracy can be obtained by selecting the scale parameter minimizing extended prediction information criterion.