Use real word data to evaluate the performance of the electrocardiographic markers of GEH as features in a machine learning model with Standard ECG features and Risk Factors in Predicting Outcome of patients in a population referred to a tertiary cardiology hospital. Patients forwarded to specific evaluation in a cardiology specialized hospital performed an ECG and a risk factor anamnesis. A series of follow up attendances occurred in periods of 6 months, 12 months and 15 months to check for cardiovascular related events (mortality or new nonfatal cardiovascular events (Stroke, MI, PCI, CS), as identified during 1-year phone follow-ups. The first attendance ECG was measured by a specialist and processed in order to obtain the global electric heterogeneity (GEH) using the Kors Matriz. The ECG measurements, GEH parameters and risk factors were combined for training multiple instances of XGBoost decision trees models. Each instance were optmized for the AUCPR and the instance with higher AUC is chosen as representative to the model. The importance of each parameter for the winner tree model was compared to better understand the improvement from using GEH parameters. The GEH parameters turned out to have statistical significance for this population specially the QRST angle and the SVG. The combined model with the tree parameters class had the best performance. The findings suggest that using VCG features can facilitate more accurate identification of patients who require tertiary care, thereby optimizing resource allocation and improving patient outcomes. Moreover, the decision tree model's transparency and ability to pinpoint critical features make it a valuable tool for clinical decision-making and align well with existing clinical practices.

This work presents an omics-driven modeling pipeline that integrates machine-learning tools to facilitate the dynamic modeling of multiscale biological systems. Random forests and permutation feature importance are proposed to mine omics datasets, guiding feature selection and dimensionality reduction for dynamic modeling. Continuous and differentiable machine-learning functions can be trained to link the reduced omics feature set to key components of the dynamic model, resulting in a hybrid model. As proof of concept, we apply this framework to a high-dimensional proteomics dataset of $\textit{Saccharomyces cerevisiae}$. After identifying key intracellular proteins that correlate with cell growth, targeted dynamic experiments are designed, and key model parameters are captured as functions of the selected proteins using Gaussian processes. This approach captures the dynamic behavior of yeast strains under varying proteome profiles while estimating the uncertainty in the hybrid model's predictions. The outlined modeling framework is adaptable to other scenarios, such as integrating additional layers of omics data for more advanced multiscale biological systems, or employing alternative machine-learning methods to handle larger datasets. Overall, this study outlines a strategy for leveraging omics data to inform multiscale dynamic modeling in systems biology and bioprocess engineering.

Predictive models often face performance degradation due to evolving data distributions, a phenomenon known as data drift. Among its forms, concept drift, where the relationship between explanatory variables and the response variable changes, is particularly challenging to detect and adapt to. Traditional drift detection methods often rely on metrics such as accuracy or variable distributions, which may fail to capture subtle but significant conceptual changes. This paper introduces drifter, an R package designed to detect concept drift, and proposes a novel method called Profile Drift Detection (PDD) that enables both drift detection and an enhanced understanding of the cause behind the drift by leveraging an explainable AI tool - Partial Dependence Profiles (PDPs). The PDD method, central to the package, quantifies changes in PDPs through novel metrics, ensuring sensitivity to shifts in the data stream without excessive computational costs. This approach aligns with MLOps practices, emphasizing model monitoring and adaptive retraining in dynamic environments. The experiments across synthetic and real-world datasets demonstrate that PDD outperforms existing methods by maintaining high accuracy while effectively balancing sensitivity and stability. The results highlight its capability to adaptively retrain models in dynamic environments, making it a robust tool for real-time applications. The paper concludes by discussing the advantages, limitations, and future extensions of the package for broader use cases.

We consider the challenge of black-box optimization within hybrid discrete-continuous and variable-length spaces, a problem that arises in various applications, such as decision tree learning and symbolic regression. We propose DisCo-DSO (Discrete-Continuous Deep Symbolic Optimization), a novel approach that uses a generative model to learn a joint distribution over discrete and continuous design variables to sample new hybrid designs. In contrast to standard decoupled approaches, in which the discrete and continuous variables are optimized separately, our joint optimization approach uses fewer objective function evaluations, is robust against non-differentiable objectives, and learns from prior samples to guide the search, leading to significant improvement in performance and sample efficiency. Our experiments on a diverse set of optimization tasks demonstrate that the advantages of DisCo-DSO become increasingly evident as the complexity of the problem increases. In particular, we illustrate DisCo-DSO's superiority over the state-of-the-art methods for interpretable reinforcement learning with decision trees.

Decision trees are a popular machine learning method, known for their inherent explainability. In Explainable AI, decision trees can be used as surrogate models for complex black box AI models or as approximations of parts of such models. A key challenge of this approach is determining how accurately the extracted decision tree represents the original model and to what extent it can be trusted as an approximation of their behavior. In this work, we investigate the use of the Probably Approximately Correct (PAC) framework to provide a theoretical guarantee of fidelity for decision trees extracted from AI models. Based on theoretical results from the PAC framework, we adapt a decision tree algorithm to ensure a PAC guarantee under certain conditions. We focus on binary classification and conduct experiments where we extract decision trees from BERT-based language models with PAC guarantees. Our results indicate occupational gender bias in these models.

In this paper, we focus on data from Randomized Controlled Experiments which guarantee causal interpretation of the outcomes. Class and treatment imbalance are important problems in uplift modeling/HTE, but classical undersampling or oversampling based approaches are hard to apply in this case since they distort the predicted effect. Calibration methods have been proposed in the past, however, they do not guarantee correct predictions. In this work, we propose an approach alternative to undersampling, based on flipping the class value of selected records. We show that the proposed approach does not distort the predicted effect and does not require calibration. The method is especially useful for models based on class variable transformation (modified outcome models). We address those models separately, designing a transformation scheme which guarantees correct predictions and addresses also the problem of treatment imbalance which is especially important for those models. Experiments fully confirm our theoretical results. Additionally, we demonstrate that our method is a viable alternative also for standard classification problems.

Efficient and effective service delivery in Public Administration (PA) relies on the development and utilization of key performance indicators (KPIs) for evaluating and measuring performance. This paper presents an innovative framework for KPI construction within performance evaluation systems, leveraging Random Forest algorithms and variable importance analysis. The proposed approach identifies key variables that significantly influence PA performance, offering valuable insights into the critical factors driving organizational success. By integrating variable importance analysis with expert consultation, relevant KPIs can be systematically developed, ensuring that improvement strategies address performance-critical areas. The framework incorporates continuous monitoring mechanisms and adaptive phases to refine KPIs in response to evolving administrative needs. This study aims to enhance PA performance through the application of machine learning techniques, fostering a more agile and results-driven approach to public administration.

Cable broadband networks are one of the few "last-mile" broadband technologies widely available in the U.S. Unfortunately, they have poor reliability after decades of deployment. The cable industry proposed a framework called Proactive Network Maintenance (PNM) to diagnose the cable networks. However, there is little public knowledge or systematic study on how to use these data to detect and localize cable network problems. Existing tools in the public domain have prohibitive high false-positive rates. In this paper, we propose CableMon, the first public-domain system that applies machine learning techniques to PNM data to improve the reliability of cable broadband networks. CableMon tackles two key challenges faced by cable ISPs: accurately detecting failures, and distinguishing whether a failure occurs within a network or at a subscriber's premise. CableMon uses statistical models to generate features from time series data and uses customer trouble tickets as hints to infer abnormal/failure thresholds for these generated features. Further, CableMon employs an unsupervised learning model to group cable devices sharing similar anomalous patterns and effectively identify impairments that occur inside a cable network and impairments occur at a subscriber's premise, as these two different faults require different types of technical personnel to repair them. We use eight months of PNM data and customer trouble tickets from an ISP and experimental deployment to evaluate CableMon's performance. Our evaluation results show that CableMon can effectively detect and distinguish failures from PNM data and outperforms existing public-domain tools.

Many important datasets contain samples that are missing one or more feature values. Maintaining the interpretability of machine learning models in the presence of such missing data is challenging. Singly or multiply imputing missing values complicates the model's mapping from features to labels. On the other hand, reasoning on indicator variables that represent missingness introduces a potentially large number of additional terms, sacrificing sparsity. We solve these problems with M-GAM, a sparse, generalized, additive modeling approach that incorporates missingness indicators and their interaction terms while maintaining sparsity through l0 regularization. We show that M-GAM provides similar or superior accuracy to prior methods while significantly improving sparsity relative to either imputation or naive inclusion of indicator variables.

Traditional studies of memory for meaningful narratives focus on specific stories and their semantic structures but do not address common quantitative features of recall across different narratives. We introduce a statistical ensemble of random trees to represent narratives as hierarchies of key points, where each node is a compressed representation of its descendant leaves, which are the original narrative segments. Recall is modeled as constrained by working memory capacity from this hierarchical structure. Our analytical solution aligns with observations from large-scale narrative recall experiments. Specifically, our model explains that (1) average recall length increases sublinearly with narrative length, and (2) individuals summarize increasingly longer narrative segments in each recall sentence. Additionally, the theory predicts that for sufficiently long narratives, a universal, scale-invariant limit emerges, where the fraction of a narrative summarized by a single recall sentence follows a distribution independent of narrative length.