Protecting individual privacy is essential across research domains, from socio-economic surveys to big-tech user data. This need is particularly acute in healthcare, where analyses often involve sensitive patient information. A typical example is comparing treatment efficacy across hospitals or ensuring consistency in diagnostic laboratory calibrations, both requiring privacy-preserving statistical procedures. However, standard equivalence testing procedures for differences in proportions or means, commonly used to assess average equivalence, can inadvertently disclose sensitive information. To address this problem, we develop differentially private equivalence testing procedures that rely on simulation-based calibration, as the finite-sample distribution is analytically intractable. Our approach introduces a unified framework, termed DP-TOST, for conducting differentially private equivalence testing of both means and proportions. Through numerical simulations and real-world applications, we demonstrate that the proposed method maintains type-I error control at the nominal level and achieves power comparable to its non-private counterpart as the privacy budget and/or sample size increases, while ensuring strong privacy guarantees. These findings establish a reliable and practical framework for privacy-preserving equivalence testing in high-stakes fields such as healthcare, among others.

This study presents a conditional flow matching framework for solving physics-constrained Bayesian inverse problems. In this setting, samples from the joint distribution of inferred variables and measurements are assumed available, while explicit evaluation of the prior and likelihood densities is not required. We derive a simple and self-contained formulation of both the unconditional and conditional flow matching algorithms, tailored specifically to inverse problems. In the conditional setting, a neural network is trained to learn the velocity field of a probability flow ordinary differential equation that transports samples from a chosen source distribution directly to the posterior distribution conditioned on observed measurements. This black-box formulation accommodates nonlinear, high-dimensional, and potentially non-differentiable forward models without restrictive assumptions on the noise model. We further analyze the behavior of the learned velocity field in the regime of finite training data. Under mild architectural assumptions, we show that overtraining can induce degenerate behavior in the generated conditional distributions, including variance collapse and a phenomenon termed selective memorization, wherein generated samples concentrate around training data points associated with similar observations. A simplified theoretical analysis explains this behavior, and numerical experiments confirm it in practice. We demonstrate that standard early-stopping criteria based on monitoring test loss effectively mitigate such degeneracy. The proposed method is evaluated on several physics-based inverse problems. We investigate the impact of different choices of source distributions, including Gaussian and data-informed priors. Across these examples, conditional flow matching accurately captures complex, multimodal posterior distributions while maintaining computational efficiency.

Dr. David Blackwell was a mathematician and statistician of the first rank, whose contributions to statistical theory, game theory, and decision theory predated many of the algorithmic breakthroughs that define modern artificial intelligence. This survey examines three of his most consequential theoretical results the Rao Blackwell theorem, the Blackwell Approachability theorem, and the Blackwell Informativeness theorem (comparison of experiments) and traces their direct influence on contemporary AI and machine learning. We show that these results, developed primarily in the 1940s and 1950s, remain technically live across modern subfields including Markov Chain Monte Carlo inference, autonomous mobile robot navigation (SLAM), generative model training, no-regret online learning, reinforcement learning from human feedback (RLHF), large language model alignment, and information design. NVIDIAs 2024 decision to name their flagship GPU architecture (Blackwell) provides vivid testament to his enduring relevance. We also document an emerging frontier: explicit Rao Blackwellized variance reduction in LLM RLHF pipelines, recently proposed but not yet standard practice. Together, Blackwell theorems form a unified framework addressing information compression, sequential decision making under uncertainty, and the comparison of information sources precisely the problems at the core of modern AI.

Accurate classification requires not only high predictive accuracy but also well-calibrated confidence estimates. Yet, modern deep neural networks (DNNs) are often overconfident, primarily due to overfitting on the negative log-likelihood (NLL). While focal loss variants alleviate this issue, they typically reduce accuracy, revealing a persistent trade-off between calibration and predictive performance. Motivated by the complementary strengths of generative and discriminative classifiers, we propose Generative Cross-Entropy (GCE), which maximizes $p(x|y)$ and is equivalent to cross-entropy augmented with a class-level confidence regularizer. Under mild conditions, GCE is strictly proper. Across CIFAR-10/100, Tiny-ImageNet, and a medical imaging benchmark, GCE improves both accuracy and calibration over cross-entropy, especially in the long-tailed scenario. Combined with adaptive piecewise temperature scaling (ATS), GCE attains calibration competitive with focal-loss variants without sacrificing accuracy.

Luminous by Silvia Park and Ode to the Half-Broken by Suzanne Palmer are both thoughtful and well-written science fiction novels, featuring robots in richly realised worlds. But there the similarities end, says Emily H. Wilson Do we relate better to stories about robots with faces and bodies? Robots and whether they will one day deserve to be treated like people - or destroy humanity, or both - have interested writers for well over a century now. In the real world, the robot threat appears to involve the uses of artificial intelligence in misinformation and more direct forms of warfare such as drone attacks. In the world of literature, however, many writers focus on individual robots.

John Pendry is known for creating an invisibility cloak. John Pendry's kitchen is dominated by a huge photograph of what looks like the view through a kaleidoscope: dizzying shards of purple, green, yellow and white. Given that Pendry is famous above all else for inventing an invisibility cloak - a device that can bend light around objects - I wonder if I am looking at something related to that. But no, he tells me, the image simply shows crystals of vitamin C magnified many times. All that invisibility-cloak stuff is in the past, he says, and he has moved on to "more exciting things".

There is a growing demand for efficient data removal to comply with regulations like the GDPR and to mitigate the influence of biased or corrupted data. This has motivated the field of machine unlearning, which aims to eliminate the influence of specific data subsets without the cost of full retraining. In this work, we propose a statistical framework for machine unlearning with generic loss functions and establish theoretical guarantees. For squared loss, especially, we develop Unlearning Least Squares (ULS) and establish its minimax optimality for estimating the model parameter of remaining data when only the pre-trained estimator, forget samples, and a small subsample of the remaining data are available. Our results reveal that the estimation error decomposes into an oracle term and an unlearning cost determined by the forget proportion and the forget model bias. We further establish asymptotically valid inference procedures without requiring full retraining. Numerical experiments and real-data applications demonstrate that the proposed method achieves performance close to retraining while requiring substantially less data access.

Multimodal representation learning is commonly built on a shared-private decomposition, treating latent information as either common to all modalities or specific to one. This binary view is often inadequate: many factors are shared by only subsets of modalities, and ignoring such partial sharing can over-align unrelated signals and obscure complementary information. We propose Hierarchical Contrastive Learning (HCL), a framework that learns globally shared, partially shared, and modality-specific representations within a unified model. HCL combines a hierarchical latent-variable formulation with structural sparsity and a structure-aware contrastive objective that aligns only modalities that genuinely share a latent factor. Under uncorrelated latent variables, we prove identifiability of the hierarchical decomposition, establish recovery guarantees for the loading matrices, and derive parameter estimation and excess-risk bounds for downstream prediction. Simulations show accurate recovery of hierarchical structure and effective selection of task-relevant components. On multimodal electronic health records, HCL yields more informative representations and consistently improves predictive performance.

The classical Gaussian mixture model assumes homogeneity within clusters, an assumption that often fails in real-world data where observations naturally exhibit varying scales or intensities. To address this, we introduce the individual-heterogeneous sub-Gaussian mixture model, a flexible framework that assigns each observation its own heterogeneity parameter, thereby explicitly capturing the heterogeneity inherent in practical applications. Built upon this model, we propose an efficient spectral method that provably achieves exact recovery of the true cluster labels under mild separation conditions, even in high-dimensional settings where the number of features far exceeds the number of samples. Numerical experiments on both synthetic and real data demonstrate that our method consistently outperforms existing clustering algorithms, including those designed for classical Gaussian mixture models.

We introduce the Hiremath Early Detection (HED) Score, a principled, measure-theoretic evaluation criterion for quantifying the time-value of information in systems operating over non-stationary stochastic processes subject to abrupt regime transitions. Existing evaluation paradigms, chiefly the ROC/AUC framework and its downstream variants, are temporally agnostic: they assign identical credit to a detection at t + 1 and a detection at t + tau for arbitrarily large tau. This indifference to latency is a fundamental inadequacy in time-critical domains including cyber-physical security, algorithmic surveillance, and epidemiological monitoring. The HED Score resolves this by integrating a baseline-neutral, exponentially decaying kernel over the posterior probability stream of a target regime, beginning precisely at the onset of the regime shift. The resulting scalar simultaneously encodes detection acuity, temporal lead, and pre-transition calibration quality. We prove that the HED Score satisfies three axiomatic requirements: (A1) Temporal Monotonicity, (A2) Invariance to Pre-Attack Bias, and (A3) Sensitivity Decomposability. We further demonstrate that the HED Score admits a natural parametric family indexed by the Hiremath Decay Constant (lambda_H), whose domain-specific calibration constitutes the Hiremath Standard Table. As an empirical vehicle, we present PARD-SSM (Probabilistic Anomaly and Regime Detection via Switching State-Space Models), which couples fractional Stochastic Differential Equations (fSDEs) with a Switching Linear Dynamical System (S-LDS) inference backend. On the NSL-KDD benchmark, PARD-SSM achieves a HED Score of 0.0643, representing a 388.8 percent improvement over a Random Forest baseline (0.0132), with statistical significance confirmed via block-bootstrap resampling (p < 0.001). We propose the HED Score as the successor evaluation standard to ROC/AUC.