We present The Matrix, a foundational realistic world simulator capable of generating infinitely long 720p high-fidelity real-scene video streams with real-time, responsive control in both first-and third-person perspectives. Trained on limited supervised data from video games like Forza Horizon 5 and Cyberpunk 2077, complemented by large-scale unsupervised footage from real-world settings like Tokyo streets, The Matrix allows users to traverse diverse terrains--deserts, grasslands, water bodies, and urban landscapes--in continuous, uncut hour-long sequences. With speeds of up to 16 FPS, the system supports real-time interactivity and demonstrates zero-shot generalization, translating virtual game environments to real-world contexts where collecting continuous movement data is often infeasible. For example, The Matrix can simulate a BMW X3 driving through an office setting--an environment present in neither gaming data nor real-world sources. This approach showcases the potential of game data to advance robust world models, bridging the gap between simulations and real-world applications in scenarios with limited data.

Neural Combinatorial Optimisation (NCO) is a promising learning-based approach for solving Vehicle Routing Problems (VRPs) without extensive manual design. While existing constructive NCO methods typically follow an appending-based paradigm that sequentially adds unvisited nodes to partial solutions, this rigid approach often leads to suboptimal results. To overcome this limitation, we explore the idea of the insertion-based paradigm and propose Learning to Construct with Insertion-based Paradigm (L2C-Insert), a novel learning-based method for constructive NCO. Unlike traditional approaches, L2C-Insert builds solutions by strategically inserting unvisited nodes at any valid position in the current partial solution, which can significantly enhance the flexibility and solution quality. The proposed framework introduces three key components: a novel model architecture for precise insertion position prediction, an efficient training scheme for model optimization, and an advanced inference technique that fully exploits the insertion paradigm's flexibility. Extensive experiments on both synthetic and real-world instances of the Travelling Salesman Problem (TSP) and Capacitated Vehicle Routing Problem (CVRP) demonstrate that L2C-Insert consistently achieves superior performance across various problem sizes.

Understanding and decoding human brain activity from electroencephalography (EEG) signals is a fundamental problem in neuroscience and artificial intelligence, with applications ranging from cognition and emotion recognition to clinical diagnosis and brain-computer interfaces. While recent EEG foundation models have made progress in generalized brain decoding by leveraging unified architectures and large-scale pretraining, they inherit a scale-agnostic dense modeling paradigm from NLP and vision. This design overlooks an intrinsic property of neural activity--cross-scale spatiotemporal structure. Different EEG task patterns span a broad range of temporal and spatial scales, from brief neural activations to slow-varying rhythms, and from localized cortical activations to large-scale distributed interactions. Ignoring this diversity may lead to suboptimal representations and weakened generalization ability.

Decoding of visual stimuli from noninvasive neuroimaging techniques such as functional magnetic resonance (fMRI) has advanced rapidly in the last years; yet, most high-performing brain decoding models rely on complicated, non-interpretable latent spaces. In this study we present an interpretable brain decoding framework that inserts a semantic bottleneck into BrainDiffuser, a well established, simple and linear decoding pipeline. We firstly produce a $214-\text{dimensional}$ binary interpretable space $\mathcal{L}$ for images, in which each dimension answers to a specific question about the image (e.g., Is there a person?, Is it outdoors?).

Elon Musk became the world's first trillionaire on Friday, following the record-breaking stock market debut of his company SpaceX. With a current estimated net worth of about $1.11tn, according to Bloomberg, Musk sits well above wealthy billionaires topping rich lists, including Google co-founders Larry Page and Sergey Brin, Amazon founder Jeff Bezos, and boss of French luxury goods group LVMH, Bernard Arnault. Musk - who first made waves in the tech industry in the late 1990s - hasn't always topped the rich list though. In January 2020, he was only the 35th richest person in the world, with a fortune of around $28bn. But his wealth took off that year as the value of his two biggest companies - electric carmaker Tesla and space exploration and AI firm SpaceX - began to grow sharply.

There is growing interest in using machine learning (ML) to support clinical diagnosis, but most approaches rely on static, fully observed datasets and fail to reflect the sequential, resource-aware reasoning clinicians use in practice. Diagnosis remains complex and error prone, especially in high-pressure or resource-limited settings, underscoring the need for frameworks that help clinicians make timely and cost-effective decisions. We propose ACTMED (Adaptive Clinical Test selection via Model-based Experimental Design), a diagnostic framework that integrates Bayesian Experimental Design (BED) with large language models (LLMs) to better emulate real-world diagnostic reasoning. At each step, ACTMED selects the test expected to yield the greatest reduction in diagnostic uncertainty for a given patient. LLMs act as flexible simulators, generating plausible patient state distributions and supporting belief updates without requiring structured, task-specific training data. Clinicians can remain in the loop; reviewing test suggestions, interpreting intermediate outputs, and applying clinical judgment throughout. We evaluate ACTMED on real-world datasets and show it can optimize test selection to improve diagnostic accuracy, interpretability, and resource use. This represents a step toward transparent, adaptive, and clinician-aligned diagnostic systems that generalize across settings with reduced reliance on domain-specific data.

Flexible docking, which predicts the binding conformations of both proteins and small molecules by modeling their structural flexibility, plays a vital role in structure-based drug design. Although recent generative approaches, particularly diffusion-based models, have shown promising results, they require iterative sampling to generate candidate structures and depend on separate scoring functions for pose selection. This leads to an inefficient pipeline that is difficult to scale in real-world drug discovery workflows. To overcome these challenges, we introduce FIGRDock, a fast and accurate flexible docking framework that understands complicated interactions between molecules and proteins with a regression-based approach. FIGRDock leverages initial docking poses from conventional tools to distill interaction-aware distance patterns, which serve as explicit structural conditions to directly guide the prediction of the final protein-ligand complex via a regression model. This one-shot inference paradigm enables rapid and precise pose prediction without reliance on multi-step sampling or external scoring stages. Experimental results show that FIGRDock achieves up to 100 faster inference than diffusion-based docking methods, while consistently surpassing them in accuracy across standard benchmarks. These results suggest that FIGRDock has the potential to offer a scalable and efficient solution for flexible docking, advancing the pace of structure-based drug discovery.

While Large Language Models (LLMs) demonstrate strong performance across domains, their long-context capabilities are limited by transient neural activations causing information decay and unstructured feed-forward network (FFN) weights leading to semantic fragmentation. Inspired by the brain's working memory and cortical modularity, we propose PaceLLM, featuring two innovations: (1) a Persistent Activity (PA) Mechanism that mimics prefrontal cortex (PFC) neurons' persistent firing by introducing an activation-level memory bank to dynamically retrieve, reuse, and update critical FFN states, addressing contextual decay; and (2) Cortical Expert (CE) Clustering that emulates task-adaptive neural specialization to reorganize FFN weights into semantic modules, establishing cross-token dependencies and mitigating fragmentation.

Invariant object recognition-the ability to identify objects despite changes in appearance-is a hallmark of visual processing in the brain, yet its understanding remains a central challenge in systems neuroscience. Artificial neural networks trained to predict neural responses to visual stimuli ("digital twins") could provide a powerful framework for studying such complex computations in silico. However, while current models accurately capture single-neuron responses within individual visual areas, their ability to reproduce how populations of neurons represent object identity, and how these representations transform across the cortical hierarchy, remains largely unexplored. Here we examine key functional signatures observed experimentally and find that current models account for hierarchical changes in basic single-neuron properties, such as receptive field size, but fail to capture more complex population-level phenomena, particularly invariant object representations. To address this gap, we introduce a biologically inspired hierarchical readout scheme that mirrors cortical anatomy, modeling each visual area as a projection from a distinct depth within a shared core network. This approach significantly improves the prediction of population-level representational transformations, outperforming standard models that use only the final layer, as well as alternatives with modified architecture, regularization, and loss function. Our results suggest that incorporating anatomical information provides a strong inductive bias in digital twin models, enabling them to better capture general principles of brain function.

Elon Musk becomes world's first trillionaire as SpaceX soars in stock market debut Elon Musk on Friday became the world's first trillionaire after shares in his SpaceX rocket company soared during the biggest-ever stock market debut. The Tesla and SpaceX founder comfortably cemented his status as the world's richest man, with his total net worth standing at $1.11tn (£828bn) according to the Bloomberg rich list. It came as the rocket, telecommunications and artificial intelligence (AI) company listed on the Nasdaq stock exchange with a value of $2.2tn. The company said its shares would be offered at $135 each, but trading opened at $150 and briefly reached $176.50 in a show of investor enthusiasm for potential business related to space and companies associated with Musk. SpaceX shares closed on Friday at about $161.