Self-knowledge distillation (SKD) enables single-model training by distilling knowledge from the model's own output, eliminating the need for a separate teacher network required in conventional distillation methods. However, current SKD methods focus mainly on replicating common features in the student model, neglecting the extraction of key features that significantly enhance student learning. Inspired by this, we devise a self-knowledge distillation framework entitled Self-Distillation training via Proximal Gradient Optimization or SDPGO, which utilizes gradient information to identify and assign greater weight to features that significantly impact classification performance, enabling the network to learn the most relevant features during training. Specifically, the proposed framework refines the gradient information into a dynamically changing weighting factor to evaluate the distillation knowledge via the dynamic weight adjustment scheme. Meanwhile, we devise the sequential iterative learning module to dynamically optimize knowledge transfer by leveraging historical predictions and real-time gradients, stabilizing training through mini-batch-based KL divergence refinement while adaptively prioritizing task-critical features for efficient self-distillation. Comprehensive experiments on image classification, object detection, and semantic segmentation demonstrate that our method consistently surpasses recent state-of-the-art knowledge distillation techniques.

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Spatio-Temporal Graph Neural Networks (STGNNs) have emerged as a powerful tool for modeling dynamic graph-structured data across diverse domains. However, they often fail to generalize in Spatio-Temporal Out-of-Distribution (STOOD) scenarios, where both temporal dynamics and spatial structures evolve beyond the training distribution. To address this problem, we propose an innovative Spatio-Temporal Retrieval-Augmented Pattern Learning framework, STRAP, which enhances model generalization by integrating retrieval-augmented learning into the STGNN continue learning pipeline. The core of STRAP is a compact and expressive pattern library that stores representative spatio-temporal patterns enriched with historical, structural, and semantic information, which is obtained and optimized during the training phase. During inference, STRAP retrieves relevant patterns from this library based on similarity to the current input and injects them into the model via a plug-and-play prompting mechanism. This not only strengthens spatio-temporal representations but also mitigates catastrophic forgetting. Moreover, STRAP introduces a knowledge-balancing objective to harmonize new information with retrieved knowledge. Extensive experiments across multiple real-world streaming graph datasets show that STRAP consistently outperforms state-of-the-art STGNN baselines on STOOD tasks, demonstrating its robustness, adaptability, and strong generalization capability without task-specific fine-tuning.

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Vision-Language Foundation Models (VLMs), trained on large-scale multimodal datasets, have driven significant advances in Artificial Intelligence (AI) by enabling rich cross-modal reasoning. Despite their success in general domains, applying these models to medical imaging remains challenging due to the limited availability of diverse imaging modalities and multilingual clinical data. Most existing medical VLMs are trained on a subset of imaging modalities and focus primarily on high-resource languages, thus limiting their generalizability and clinical utility. To address these limitations, we introduce a novel Vietnamese-language multimodal medical dataset consisting of 2,757 whole-body PET/CT volumes from independent patients and their corresponding full-length clinical reports. This dataset is designed to fill two pressing gaps in medical AI development: (1) the lack of PET/CT imaging data in existing VLMs training corpora, which hinders the development of models capable of handling functional imaging tasks; and (2) the underrepresentation of low-resource languages, particularly the Vietnamese language, in medical vision-language research.

While large transformer models excel in predictive performance, their lack of interpretability restricts their usefulness in high-stakes domains. To remedy this, we propose the Generalized Induction-Head Model (GIM), an interpretable model for next-token prediction inspired by the observation of "induction heads" in LLMs. GIM is a retrieval-based module that identifies similar sequences in the input context by combining exact n-gram matching and fuzzy matching based on a neural similarity metric. We evaluate GIM in two settings: language modeling and fMRI response prediction. In language modeling, GIM improves next-token prediction by up to 25%p over interpretable baselines, significantly narrowing the gap with black-box LLMs. In an fMRI setting, GIM improves neural response prediction by 20% and offers insights into the language selectivity of the brain. GIM represents a significant step toward uniting interpretability and performance across domains.

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Prompt learning has emerged as a promising paradigm for adapting pre-trained vision-language models (VLMs) to few-shot whole slide image (WSI) classification by aligning visual features with textual representations, thereby reducing annotation cost and enhancing model generalization. Nevertheless, existing methods typically rely on slide-level prompts and fail to capture the subtype-specific phenotypic variations of histological entities (e.g., nuclei, glands) that are critical for cancer diagnosis. To address this gap, we propose Multi-scale Attribute-enhanced Prompt Learning (MAPLE), a hierarchical framework for few-shot WSI classification that jointly integrates multi-scale visual semantics and performs prediction at both the entity and slide levels. Specifically, we first leverage large language models (LLMs) to generate entity-level prompts that can help identify multi-scale histological entities and their phenotypic attributes, as well as slide-level prompts to capture global visual descriptions. Then, an entity-guided cross-attention module is proposed to generate entity-level features, followed by aligning with their corresponding subtype-specific attributes for fine-grained entity-level prediction. To enrich entity representations, we further develop a cross-scale entity graph learning module that can update these representations by capturing their semantic correlations within and across scales. The refined representations are then aggregated into a slide-level representation and aligned with the corresponding prompts for slide-level prediction. Finally, we combine both entity-level and slide-level outputs to produce the final prediction results. Results on three cancer cohorts confirm the effectiveness of our approach in addressing few-shot pathology diagnosis tasks.

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Spatial transcriptomics (ST) technologies provide gene expression measurements with spatial resolution, enabling the dissection of tissue structure and function. A fundamental challenge in ST analysis is clustering spatial spots into coherent functional regions. While existing models effectively integrate expression and spatial signals, they largely overlook sequence-level biological priors encoded in the DNA sequences of expressed genes. To bridge this gap, we propose SAINT (Sequence-Aware Integration for Nucleotide-informed Transcriptomics), a unified framework that augments spatial representation learning with nucleotide-derived features. We construct sequence-augmented datasets across 14 tissue sections from three widely used ST benchmarks (DLPFC, HBC, and MBA), retrieving reference DNA sequences for each expressed gene and encoding them using a pretrained Nucleotide Transformer. For each spot, gene-level embeddings are aggregated via expression-weighted and attention-based pooling, then fused with spatial-expression representations through a late fusion module. Extensive experiments demonstrate that SAINT consistently improves clustering performance across multiple datasets.