Latent Diffusion Models (LDMs) have markedly advanced the quality of image inpainting and local editing. However, the inherent latent compression often introduces pixel-level inconsistencies, such as chromatic shifts, texture mismatches, and visible seams along editing boundaries. Existing remedies, including backgroundconditioned latent decoding and pixel-space harmonization, usually fail to fully eliminate these artifacts in practice and do not generalize well across different latent representations or tasks. We introduce PixPerfect, a pixel-level refinement framework that delivers seamless, high-fidelity local edits across diverse LDM architectures and tasks. PixPerfect leverages (i) a differentiable discriminative pixel space that amplifies and suppresses subtle color and texture discrepancies, (ii) a comprehensive artifact simulation pipeline that exposes the refiner to realistic local editing artifacts during training, and (iii) a direct pixel-space refinement scheme that ensures broad applicability across diverse latent representations and tasks. Extensive experiments on inpainting, object removal, and insertion benchmarks demonstrate that PixPerfect substantially enhances perceptual fidelity and downstream editing performance, establishing a new standard for robust and high-fidelity localized image editing.

Network traffic classification is essential for network management and security. In recent years, deep learning (DL) algorithms have emerged as essential tools for classifying complex traffic. However, they rely heavily on high-quality labeled training data. In practice, traffic data is often noisy due to human error or inaccurate automated labeling, which could render classification unreliable and lead to severe consequences. Although some studies have alleviated the label noise issue in specific scenarios, they are difficult to generalize to general traffic classification tasks due to the inherent semantic complexity of traffic data.

Clinical reasoning in medicine is a hypothesis-driven process where physicians refine diagnoses from limited information through targeted history, physical examination, and diagnostic investigations. In contrast, current medical benchmarks for large language models (LLMs) primarily assess knowledge recall through single-turn questions, where complete clinical information is provided upfront. To address this gap, we introduce VivaBench, a multi-turn benchmark that evaluates sequential clinical reasoning in LLM agents. Our dataset comprises 1152 physiciancurated clinical vignettes structured as interactive scenarios that simulate a viva voce examination in medical training, requiring agents to actively probe for relevant findings, select appropriate investigations, and synthesize information across multiple steps to reach a diagnosis. We evaluated several state-of-the-art LLMs and found that while models demonstrate competence in diagnosing conditions within well-described clinical presentations, their performance degrades significantly when required to navigate diagnostic uncertainty. Our analysis identified several failure modes that mirror common issues in clinical practice, including: (1) fixation on initial hypotheses, (2) excessive investigation ordering, (3) premature diagnostic closure, and (4) missing critical conditions. These patterns reveal fundamental limitations in how current LLMs manage uncertainty and gather information sequentially. Through VivaBench, we provide a standardized benchmark for evaluating conversational medical AI systems for real-world clinical decision support. Beyond medical applications, we contribute to the larger corpus of research on agentic AI by demonstrating how sequential reasoning trajectories can diverge in complex decision-making environments.

Federated learning (FL) is now recognized as a key framework for communicationefficient collaborative learning. Most theoretical and empirical studies, however, rely on the assumption that clients have access to pre-collected data sets, with limited investigation into scenarios where clients continuously collect data. In many real-world applications, particularly when data is generated by physical or biological processes, client data streams are often modeled by non-stationary Markov processes.

Quantification learning is the task of predicting the label distribution of a set of instances. We study this problem in the context of graph-structured data, where the instances are vertices. Previously, this problem has only been addressed via node clustering methods. In this paper, we extend the popular Adjusted Classify & Count (ACC) method to graphs. We show that the prior probability shift assumption upon which ACC relies is often not applicable to graph quantification problems. To address this issue, we propose structural importance sampling (SIS), the first graph quantification method that is applicable under (structural) covariate shift. Additionally, we propose Neighborhood-aware ACC, which improves quantification in the presence of non-homophilic edges. We show the effectiveness of our techniques on multiple graph quantification tasks.

Predicting disease risk from DNA presents an unprecedented emerging challenge as biobanks approach population scale sizes (N > 106 individuals) with ultra-highdimensional features (L > 105 genotypes). Current methods, often linear and reliant on summary statistics, fail to capture complex genetic interactions and discard valuable individual-level information. We introduce PRSformer, a scalable deep learning architecture designed for end-to-end, multitask disease prediction directly from million-scale individual genotypes. PRSformer employs neighborhood attention, achieving linear O(L) complexity per layer, making Transformers tractable for genome-scale inputs. Crucially, PRSformer utilizes a stacking of these efficient attention layers, progressively increasing the effective receptive field to model local dependencies (e.g., within linkage disequilibrium blocks) before integrating information across wider genomic regions. This design, tailored for genomics, allows PRSformer to learn complex, potentially non-linear and long-range interactions directly from raw genotypes. We demonstrate PRSformer's effectiveness using a unique large private cohort (N 5M) for predicting 18 autoimmune and inflammatory conditions using L 140k variants. PRSformer significantly outperforms highly optimized linear models trained on the same individual-level data and state-of-the-art summary-statistic-based methods (LDPred2) derived from the same cohort, quantifying the benefits of non-linear modeling and multitask learning at scale. Furthermore, experiments reveal that the advantage of non-linearity emerges primarily at large sample sizes (N > 1M), and that a multi-ancestry trained model improves generalization, establishing PRSformer as a new framework for deep learning in population-scale genomics.

Series Section Electron Microscopy (ssEM) has emerged as a pivotal technology for deciphering nanoscale biological architectures. Three-dimensional (3D) registration is a critical step in ssEM, tasked with rectifying axial misalignments and nonlinear distortions introduced during serial sectioning. The core scientific challenge lies in achieving distortion mitigation without erasing the natural morphological deformations of biological tissues, thereby enabling faithful reconstruction of 3D ultrastructural organization. In this study, we present a paradigm-shifting optimization framework that rethinks 3D registration through the lens of manifold trajectory optimization. We propose the first continuous trajectory dynamics formulation for 3D registration and introduce a novel optimization strategy. Specifically, we introduce a dual optimization objective that inherently balances global trajectory smoothness with local structural preservation, while developing a solver that combines Gauss-Seidel iteration with Neural ODEs to systematically integrate biophysical priors with data-driven deformation compensation. Extensive experiments on multiple datasets spanning diverse tissue types demonstrate our method's superior performance in structural restoration accuracy and cross-tissue robustness.

Synthetic image detectors (SIDs) are a key defense against the risks posed by the growing realism of images from text-to-image (T2I) models. Red teaming improves SID's effectiveness by identifying and exploiting their failure modes via misclassified synthetic images. However, existing red-teaming solutions (i) require white-box access to SIDs, which is infeasible for proprietary state-of-the-art detectors, and (ii) generate image-specific attacks through expensive online optimization. To address these limitations, we propose PolyJuice, the first black-box, imageagnostic red-teaming method for SIDs, based on an observed distribution shift in the T2I latent space between samples correctly and incorrectly classified by the SID. PolyJuice generates attacks by (i) identifying the direction of this shift through a lightweight offline process that only requires black-box access to the SID, and (ii) exploiting this direction by universally steering all generated images towards the SID's failure modes. PolyJuice-steered T2I models are significantly more effective at deceiving SIDs (up to 84%) compared to their unsteered counterparts. We also show that the steering directions can be estimated efficiently at lower resolutions and transferred to higher resolutions using simple interpolation, reducing computational overhead. Finally, tuning SID models on PolyJuice-augmented datasets notably enhances the performance of the detectors (up to 30%).

The sparse additive model (SpAM) offers a trade-off between interpretability and flexibility, and hence is a powerful model for high-dimensional research. This paper focuses on the variable selection, i.e., the univariate function selection problem in SpAM. We establish the minimax separation rates from both the perspectives of sparse multiple testing (FDR + FNR control) and support recovery (wrong recovery probability control). We further study how adaptation to unknown smoothness affects the minimax separation rate, and propose an adaptive selection procedure. Finally, we discuss the difference between estimation and selection in SpAM: Procedures achieving optimal function estimation may fail to achieve optimal univariate function selection.

Removing the limit on simultaneous drone use by one person is aimed at optimizing logistics and infrastructure inspections, and at making damage assessment and search operations more effective during disasters. The transport ministry has lifted the upper limit on the number of drones that can be operated by a single pilot at the same time, officials said. Previously, the number was set at five. Removing the limit is aimed at optimizing logistics and infrastructure inspections, and at making damage assessment and search operations more effective during disasters. In March 2025, the ministry set guidelines for using multiple drones at once.