Protein-protein interactions (PPIs) are governed by surface complementarity and hydrophobic interactions at protein interfaces. However, designing diverse and physically realistic protein structure and surfaces that precisely complement target receptors remains a significant challenge in computational protein design. In this work, we introduce PepBridge, a novel framework for the joint design of protein surface and structure that seamlessly integrates receptor surface geometry and biochemical properties. Starting with a receptor surface represented as a 3D point cloud, PepBridge generates complete protein structures through a multi-step process. First, it employs denoising diffusion bridge models (DDBMs) to map receptor surfaces to ligand surfaces. Next, a multi-model diffusion model predicts the corresponding structure, while Shape-Frame Matching Networks ensure alignment between surface geometry and backbone architecture. This integrated approach facilitates surface complementarity, conformational stability, and chemical feasibility. Extensive validation across diverse protein design scenarios demonstrates PepBridge's efficacy in generating structurally viable proteins, representing a significant advancement in the joint design of top-down protein structure.

WiFi sensing has emerged as a compelling contactless modality for human activity monitoring by capturing fine-grained variations in Channel State Information (CSI). Its ability to operate continuously and non-intrusively while preserving user privacy makes it particularly suitable for health monitoring. However, existing WiFi sensing systems struggle to generalize in real-world settings, largely due to datasets collected in controlled environments with homogeneous hardware and fragmented, session-based recordings that fail to reflect continuous daily activity. We present CSI-Bench, a large-scale, in-the-wild benchmark dataset collected using commercial WiFi edge devices across 26 diverse indoor environments with 35 real users.

The current paradigm of test-time scaling relies on generating long reasoning traces ("thinking" more) before producing a response. In agent problems that require interaction, this can be done by generating thinking traces before acting in the world. However, this process does not allow agents to acquire new information from the environment or adapt their behavior over time. In this work, we propose to scale test-time interaction, an untapped dimension of test-time scaling that increases the agent's interaction horizon to enable running rich behaviors such as exploration, backtracking, and dynamic re-planning within a single rollout. To demonstrate the promise of this scaling dimension, we study the domain of web agents.

The growing prevalence of streaming data and increasing concerns over data privacy pose significant challenges for traditional nonparametric regression methods, which are often ill-suited for real-time, privacy-aware learning. In this paper, we tackle these issues by first proposing a novel one-pass online functional stochastic gradient descent algorithm that leverages the Huber loss (H-FSGD), to improve robustness against outliers and heavy-tailed errors in dynamic environments. To further accommodate privacy constraints, we introduce a locally differentially private extension, Private H-FSGD (PH-FSGD), designed to real-time, privacy-preserving estimation. Theoretically, we conduct a comprehensive non-asymptotic convergence analysis of the proposed estimators, establishing finite-sample guarantees and identifying optimal step size schedules that achieve optimal convergence rates. In particular, we provide practical insights into the impact of key hyperparameters, such as step size and privacy budget, on convergence behavior. Extensive experiments validate our theoretical findings, demonstrating that our methods achieve strong robustness and privacy protection without sacrificing efficiency.

Autonomous agentic AI systems powered by vision-language models (VLMs) are rapidly advancing toward real-world deployment, yet their cross-modal reasoning capabilities introduce new attack surfaces for adversarial manipulation that exploit semantic reasoning across modalities. Existing adversarial attacks typically rely on visible pixel perturbations or require privileged model or environment access, making them impractical for stealthy, real-world exploitation. We introduce TRAP, a novel generative adversarial framework that manipulates the agent's decision-making using diffusion-based semantic injections into the vision-language embedding space. Our method combines negative prompt-based degradation with positive semantic optimization, guided by a Siamese semantic network and layout-aware spatial masking. Without requiring access to model internals, TRAP produces visually natural images yet induces consistent selection biases in agentic AI systems. We evaluate TRAP on the Microsoft Common Objects in Context (COCO) dataset, building multi-candidate decision scenarios. Across these scenarios, TRAP consistently induces decision-level preference redirection on leading models, including LLaVA-34B, Gemma3, GPT-4o, and Mistral-3.2,

Open-vocabulary scene graph generation (OVSGG) extends traditional SGG by recognizing novel objects and relationships beyond predefined categories, leveraging the knowledge from pre-trained large-scale models. Existing OVSGG methods always adopt a two-stage pipeline: 1) Infusing knowledge into large-scale models via pre-training on large datasets; 2) Transferring knowledge from pre-trained models with fully annotated scene graphs during supervised fine-tuning. However, due to a lack of explicit interaction modeling, these methods struggle to distinguish between interacting and non-interacting instances of the same object category. This limitation induces critical issues in both stages of OVSGG: it generates noisy pseudo-supervision from mismatched objects during knowledge infusion, and causes ambiguous query matching during knowledge transfer. To this end, in this paper, we propose an interACtion-Centric end-to-end OVSGG framework (ACC) in an interaction-driven paradigm to minimize these mismatches. For interactioncentric knowledge infusion, ACC employs a bidirectional interaction prompt for robust pseudo-supervision generation to enhance the model's interaction knowledge. For interaction-centric knowledge transfer, ACC first adopts interaction-guided query selection that prioritizes pairing interacting objects to reduce interference from non-interacting ones. Then, it integrates interaction-consistent knowledge distillation to bolster robustness by pushing relational foreground away from the background while retaining general knowledge. Extensive experimental results on three benchmarks show that ACC achieves state-of-the-art performance, demonstrating the potential of interaction-centric paradigms for real-world applications.

Modern foundation models are trained on diverse datasets to enhance generalization across tasks and domains. A central challenge in this process is determining how to effectively mix and sample data from multiple sources. This naturally leads to a multi-task learning (MTL) perspective. While prior work in MTL has emphasized mitigating gradient conflicts, we observe that large-scale pretraining scenarios--such as multilingual or multi-domain training--often exhibit little to no gradient conflict. Motivated by this observation, we propose PiKE (Positive gradient interaction-based K-task weights Estimator), an adaptive data mixing algorithm that dynamically adjusts sampling weights during training. PiKE exploits non-conflicting gradient interactions to minimize a near-tight upper bound on the average loss decrease at each step, while incurring negligible computational overhead. We provide theoretical convergence guarantees and show that PiKE outperforms static and non-adaptive mixing baselines. Furthermore, we extend PiKE to promote balanced learning across tasks. Extensive experiments on largescale language model pretraining confirm that PiKE achieves faster convergence and improved downstream performance compared to existing approaches.

Physiological signals are often corrupted by motion artifacts, baseline drift, and other low-SNR disturbances, which pose significant challenges for analysis. Additionally, these signals exhibit strong non-stationarity, with sharp peaks and abrupt changes that evolve continuously, making them difficult to represent using traditional time-domain or filtering methods. To address these issues, a novel waveletbased approach for physiological signal analysis is presented, aiming to capture multi-scale time-frequency features in various physiological signals. Leveraging this technique, two large-scale pretrained models specific to EMG and ECG are introduced for the first time, achieving superior performance and setting new baselines in downstream tasks. Additionally, a unified multi-modal framework is constructed by integrating pretrained EEG model, where each modality is guided through its dedicated branch and fused via learnable weighted fusion. This design effectively addresses challenges such as low signal-to-noise ratio, high inter-subject variability, and device mismatch, outperforming existing methods on multi-modal tasks. The proposed wavelet-based architecture lays a solid foundation for analysis of diverse physiological signals, while the multi-modal design points to nextgeneration physiological signal processing with potential impact on wearable health monitoring, clinical diagnostics, and broader biomedical applications.

Point cloud completion, aiming to reconstruct missing part from incomplete point clouds, is a pivotal task in 3D computer vision. Traditional supervised approaches often necessitate complete point clouds for training supervision, which are not readily accessible in real-world applications. Recent studies have attempted to mitigate this dependency by employing self-supervise mechanisms. However, these approaches frequently yield suboptimal results due to the absence of complete structure in the point cloud data during training. To address these issues, in this paper, we propose an effective framework to complete the point cloud under the guidance of self learned complete structure. A key contribution of our work is the development of a novel self-supervised complete structure reconstruction module, which can learn the complete structure explicitly from incomplete point clouds and thus eliminate the reliance on training data from complete point clouds. Additionally, we introduce a contrastive learning approach at both the clusterand instance-level to extract shape features guided by the complete structure and to capture style features, respectively. This dual-level learning design ensures that the generated point clouds are both shape-completed and detail-preserving. Extensive experiments on both synthetic and real-world datasets demonstrate that our approach significantly outperforms state-of-the-art self-supervised methods.

Weak-to-strong generalization refers to the phenomenon where a stronger model trained under supervision from a weaker one can outperform its teacher. While prior studies aim to explain this effect, most theoretical insights are limited to abstract frameworks or linear/random feature models. In this paper, we provide a formal analysis of weak-to-strong generalization from a linear CNN (weak) to a two-layer ReLUCNN (strong). We consider structured data composed of labeldependent signals of varying difficulty and label-independent noise, and analyze gradient descent dynamics when the strong model is trained on data labeled by the pretrained weak model. Our analysis identifies two regimes--data-scarce and data-abundant--based on the signal-to-noise characteristics of the dataset, and reveals distinct mechanisms of weak-to-strong generalization. In the datascarce regime, generalization occurs via benign overfitting or fails via harmful overfitting, depending on the amount of data, and we characterize the transition boundary. In the data-abundant regime, generalization emerges in the early phase through label correction, but we observe that overtraining can subsequently degrade performance.