What Does the Hippocampus Compute?: A Precis of the 1993 NIPS Workshop Computational models of the hippocampal-region provide an important method for understanding the functional role of this brain system in learning and memory. The presentations in this workshop focused on how modeling can lead to a unified understanding of the interplay among hippocampal physiology, anatomy, and behavior. One approach can be characterized as "top-down" analyses of the neuropsychology of memory, drawing upon brain-lesion studies in animals and humans. Other models take a "bottom-up" approach, seeking to infer emergent computational and functional properties from detailed analyses of circuit connectivity and physiology (see Gluck & Granger, 1993, for a review). Among the issues discussed were: (1) integration of physiological and behavioral theories of hippocampal function, (2) similarities and differences between animal and human studies, (3) representational vs. temporal properties of hippocampaldependent behaviors, (4) rapid vs. incremental learning, (5) mUltiple vs. unitary memory systems, (5) spatial navigation and memory, and (6) hippocampal interaction with other brain systems.

The model consists of a two-dimensional sheet of leaky integrateand-fire neurons with feedback connectivity consisting of local excitation and surround inhibition. Each neuron is independently driven by homogeneous external noise. Spontaneous symmetry breaking occurs, resulting in the formation of "hotspots" of activity in the network. These localized patterns of excitation appear as clusters that coalesce, disintegrate, or fluctuate in size while simultaneously moving in a random walk constrained by the interaction with other clusters. The emergent cross-correlation functions have a dual structure, with a sharp peak around zero on top of a much broader hill.

This inverse dynamics model allows the use of a faster speech mot.or control scheme, which can be applied to phoneme-tospeech synthesis via musclo-skeletal system dynamics, or to future use in speech recognition. The forward acoustic model, which is the mapping from articulator trajectories t.o the acoustic parameters, was improved by adding velocity and voicing information inputs to distinguish acollst.ic

Sound localization by the barn owl (tyto alba) measured with the search coil technique.

The purpose of this workshop was to discuss both recent experimental findings and computational models of the neurobiological implementation of selective attention. Recent experimental results were presented in two of the four presentations given (C.E. Connor, Washington University and B.C. Motter, SUNY and V.A. Medical Center, Syracuse), while the other two talks were devoted to computational models (E. Connor presented the results of an experiment in which the receptive field profiles of V 4 neurons were mapped during different states of attention in an awake, behaving monkey. The attentional focus was manipulated in this experiment by altering the position of a behaviorally relevant ring-shaped stimulus.

In an effort to understand saccadic eye movements and their relation to visual attention and other forms of eye movements, we - in collaboration with a number of other laboratories - are carrying out a large-scale effort to design and build a complete primate oculomotor system using analog CMOS VLSI technology. Using this technology, a low power, compact, multi-chip system has been built which works in real-time using real-world visual inputs. We describe in this paper the performance of an early version of such a system including a 1-D array of photoreceptors mimicking the retina, a circuit computing the mean location of activity representing the superior colliculus, a saccadic burst generator, and a one degree-of-freedom rotational platform which models the dynamic properties of the primate oculomotor plant. 1 Introduction When we look around our environment, we move our eyes to center and stabilize objects of interest onto our fovea. In order to achieve this, our eyes move in quick jumps with short pauses in between. These quick jumps (up to 750 deg/sec in humans) are known as saccades and are seen in both exploratory eye movements and as reflexive eye movements in response to sudden visual, auditory, or somatosensory stimuli. Since the intent of the saccade is to bring new objects of interest onto the fovea, it can be considered a primitive attentional mechanism.

Human genes are not continuous but rather consist of short coding regions (exons) interspersed with highly variable non-coding regions (introns). We apply HMMs to the problem of modeling exons, introns and detecting splice sites in the human genome. Our most interesting result so far is the detection of particular oscillatory patterns, with a minimal period ofroughly 10 nucleotides, that seem to be characteristic of exon regions and may have significant biological implications.

Previously, we had developed the concept of a Segmental Neural Net (SNN) for phonetic modeling in continuous speech recognition (CSR). This kind of neu ral network technology advanced the state-of-the-art of large-vocabulary CSR, which employs Hidden Marlcov Models (HMM), for the ARPA 1oo0-word Resource Management corpus. More Recently, we started porting the neural net system to a larger, more challenging corpus - the ARPA 20,Ooo-word Wall Street Journal (WSJ) corpus. During the porting, we explored the following research directions to refine the system: i) training context-dependent models with a regularization method; ii) training SNN with projection pursuit; and ii) combining different models into a hybrid system. When tested on both a development set and an independent test set, the resulting neural net system alone yielded a perfonnance at the level of the HMM system, and the hybrid SNN/HMM system achieved a consistent 10-15% word error reduction over the HMM system. This paper describes our hybrid system, with emphasis on the optimization methods employed.

A gradient descent algorithm for parameter estimation which is similar to those used for continuous-time recurrent neural networks was derived for Hodgkin-Huxley type neuron models. Using membrane potential trajectories as targets, the parameters (maximal conductances, thresholds and slopes of activation curves, time constants) were successfully estimated. The algorithm was applied to modeling slow non-spike oscillation of an identified neuron in the lobster stomatogastric ganglion. A model with three ionic currents was trained with experimental data. It revealed a novel role of A-current for slow oscillation below -50 mY. 1 INTRODUCTION Conductance-based neuron models, first formulated by Hodgkin and Huxley [10], are commonly used for describing biophysical mechanisms underlying neuronal behavior.

A fast event-driven software simulator has been developed for simulating large networks of spiking neurons and synapses. The primitive network elements are designed to exhibit biologically realistic behaviors, such as spiking, refractoriness, adaptation, axonal delays, summation of post-synaptic current pulses, and tonic current inputs. The efficient event-driven representation allows large networks to be simulated in a fraction of the time that would be required for a full compartmental-model simulation. Corresponding analog CMOS VLSI circuit primitives have been designed and characterized, so that large-scale circuits may be simulated prior to fabrication. 1 Introduction Artificial neural networks typically use an abstraction of real neuron behaviour, in which the continuously varying mean firing rate of the neuron is presumed to carry the information about the neuron's time-varying state of excitation [1]. This useful simplification allows the neuron's state to be represented as a time-varying continuous-amplitude quantity.