Almost all models of orientation and direction selectivity in visual cortex are based on feedforward connection schemes, where geniculate input provides all excitation to both pyramidal and inhibitory neurons. The latter neurons then suppress the response of the former for non-optimal stimuli. However, anatomical studies show that up to 90 % of the excitatory synaptic input onto any cortical cell is provided by other cortical cells. The massive excitatory feedback nature of cortical circuits is embedded in the canonical microcircuit of Douglas &. Martin (1991). We here investigate analytically and through biologically realistic simulations the functioning of a detailed model of this circuitry, operating in a hysteretic mode. In the model, weak geniculate input is dramatically amplified by intracortical excitation, while inhibition has a dual role: (i) to prevent the early geniculate-induced excitation in the null direction and (ii) to restrain excitation and ensure that the neurons fire only when the stimulus is in their receptive-field.

The TNM staging system has been used since the early 1960's to predict breast cancer patient outcome. In an attempt to increase prognostic accuracy, many putative prognostic factors have been identified. Because the TNM stage model can not accommodate these new factors, the proliferation of factors in breast cancer has lead to clinical confusion. What is required is a new computerized prognostic system that can test putative prognostic factors and integrate the predictive factors with the TNM variables in order to increase prognostic accuracy. Using the area under the curve of the receiver operating characteristic, we compare the accuracy of the following predictive models in terms of five year breast cancer-specific survival: pTNM staging system, principal component analysis, classification and regression trees, logistic regression, cascade correlation neural network, conjugate gradient descent neural, probabilistic neural network, and backpropagation neural network. Several statistical models are significantly more ac- 1064 Harry B. Burke, David B. Rosen, Philip H. Goodman

The localization and orientation to various novel or interesting events in the environment is a critical sensorimotor ability in all animals, predator or prey. In mammals, the superior colliculus (SC) plays a major role in this behavior, the deeper layers exhibiting topographically mapped responses to visual, auditory, and somatosensory stimuli. Sensory information arriving from different modalities should then be represented in the same coordinate frame. Auditory cues, in particular, are thought to be computed in head-based coordinates which must then be transformed to retinal coordinates. In this paper, an analog VLSI implementation for auditory localization in the azimuthal plane is described which extends the architecture proposed for the barn owl to a primate eye movement system where further transformation is required. This transformation is intended to model the projection in primates from auditory cortical areas to the deeper layers of the primate superior colliculus. This system is interfaced with an analog VLSI-based saccadic eye movement system also being constructed in our laboratory.

Songbirds learn to imitate a tutor song through auditory and motor learning. We have developed a theoretical framework for song learning that accounts for response properties of neurons that have been observed in many of the nuclei that are involved in song learning. Specifically, we suggest that the anteriorforebrain pathway, which is not needed for song production in the adult but is essential for song acquisition, provides synaptic perturbations and adaptive evaluations for syllable vocalization learning. A computer model based on reinforcement learning was constructed that could replicate a real zebra finch song with 90% accuracy based on a spectrographic measure. The second generation of the birdsong model replicated the tutor song with 96% accuracy.

One of the fundamental properties that both neural networks and the central nervous system share is the ability to learn and generalize from examples. While this property has been studied extensively in the neural network literature it has not been thoroughly explored in human perceptual and motor learning. We have chosen a coordinate transformation system-the visuomotor map which transforms visual coordinates into motor coordinates-to study the generalization effects of learning new input-output pairs. Using a paradigm of computer controlled altered visual feedback, we have studied the generalization of the visuomotor map subsequent to both local and context-dependent remappings. A local remapping of one or two input-output pairs induced a significant global, yet decaying, change in the visuomotor map, suggesting a representation for the map composed of units with large functional receptive fields. Our study of context-dependent remappings indicated that a single point in visual space can be mapped to two different finger locations depending on a context variable-the starting point of the movement. Furthermore, as the context is varied there is a gradual shift between the two remappings, consistent with two visuomotor modules being learned and gated smoothly with the context. 1 Introduction The human central nervous system (CNS) receives sensory inputs from a multitude of modalities, each tuned to extract different forms of information from the 1126 Zoubin Ghahramani, Daniel M. Wolpert, Michael 1. Jordan

The macaque lateral geniculate nucleus (LGN) exhibits an intricate lamination pattern, which changes midway through the nucleus at a point coincident with small gaps due to the blind spot in the retina. We present a three-dimensional model of morphogenesis in which local cell interactions cause a wave of development of neuronal receptive fields to propagate through the nucleus and establish two distinct lamination patterns. We examine the interactions between the wave and the localized singularities due to the gaps, and find that the gaps induce the change in lamination pattern. We explore critical factors which determine general LGN organization.

A biological neuron can be viewed as a device that maps a multidimensional temporal event signal (dendritic postsynaptic activations) into a unidimensional temporal event signal (action potentials). We have designed a network, the Spatio-Temporal Event Mapping (STEM) architecture, which can learn to perform this mapping for arbitrary biophysical models of neurons. Such a network appropriately trained, called a STEM cell, can be used in place of a conventional compartmental model in simulations where only the transfer function is important, such as network simulations. The STEM cell offers advantages over compartmental models in terms of computational efficiency, analytical tractabili1ty, and as a framework for VLSI implementations of biological neurons.

An analogue VLSI neural network has been designed and tested to perform cardiac morphology classification tasks. Analogue techniques were chosen to meet the strict power and area requirements of an Implantable Cardioverter Defibrillator (ICD) system. The robustness of the neural network architecture reduces the impact of noise, drift and offsets inherent in analogue approaches. The network is a 10:6:3 multi-layer percept ron with on chip digital weight storage, a bucket brigade input to feed the Intracardiac Electrogram (ICEG) to the network and has a winner take all circuit at the output. The network was trained in loop and included a commercial ICD in the signal processing path. The system has successfully distinguished arrhythmia for different patients with better than 90% true positive and true negative detections for dangerous rhythms which cannot be detected by present ICDs. The chip was implemented in 1.2um CMOS and consumes less than 200n W maximum average power in an area of 2.2 x 2.2mm2.

We describe a framework for real-time tracking of facial expressions that uses neurally-inspired correlation and interpolation methods. A distributed view-based representation is used to characterize facial state, and is computed using a replicated correlation network. The ensemble response of the set of view correlation scores is input to a network based interpolation method, which maps perceptual state to motor control states for a simulated 3-D face model. Activation levels of the motor state correspond to muscle activations in an anatomically derived model. By integrating fast and robust 2-D processing with 3-D models, we obtain a system that is able to quickly track and interpret complex facial motions in real-time.

We implement and study a computational model of Stevens' [19921 theory of the pathogenesis of schizophrenia. This theory hypothesizes that the onset of schizophrenia is associated with reactive synaptic regeneration occurring in brain regions receiving degenerating temporal lobe projections. Concentrating on one such area, the frontal cortex, we model a frontal module as an associative memory neural network whose input synapses represent incoming temporal projections. We analyze how, in the face of weakened external input projections, compensatory strengthening of internal synaptic connections and increased noise levels can maintain memory capacities (which are generally preserved in schizophrenia). However, These compensatory changes adversely lead to spontaneous, biased retrieval of stored memories, which corresponds to the occurrence of schizophrenic delusions and hallucinations without any apparent external trigger, and for their tendency to concentrate on just few central themes. Our results explain why these symptoms tend to wane as schizophrenia progresses, and why delayed therapeutical intervention leads to a much slower response.