Selective suppression of transmission at feedback synapses during learning is proposed as a mechanism for combining associative feedback with self-organization of feed forward synapses. Experimental data demonstrates cholinergic suppression of synaptic transmission in layer I (feedback synapses), and a lack of suppression in layer IV (feedforward synapses). A network with this feature uses local rules to learn mappings which are not linearly separable. During learning, sensory stimuli and desired response are simultaneously presented as input. Feedforward connections form self-organized representations of input, while suppressed feedback connections learn the transpose of feedforward connectivity. During recall, suppression is removed, sensory input activates the self-organized representation, and activity generates the learned response.

Most current methods for prediction of protein secondary structure use a small window of the protein sequence to predict the structure of the central amino acid. We describe a new method for prediction of the non-local structure called,8-sheet, which consists of two or more,8-strands that are connected by hydrogen bonds. Since,8-strands are often widely separated in the protein chain, a network with two windows is introduced. After training on a set of proteins the network predicts the sheets well, but there are many false positives. By using a global energy function the,8-sheet prediction is combined with a local prediction of the three secondary structures a-helix,,8-strand and coil.

There is currently considerable interest in developing general nonlinear density models based on latent, or hidden, variables. Such models have the ability to discover the presence of a relatively small number of underlying'causes' which, acting in combination, give rise to the apparent complexity of the observed data set. Unfortunately, to train such models generally requires large computational effort. In this paper we introduce a novel latent variable algorithm which retains the general nonlinear capabilities of previous models but which uses a training procedure based on the EM algorithm. We demonstrate the performance of the model on a toy problem and on data from flow diagnostics for a multiphase oil pipeline.

We present results on the use of neural network based autoassociators which act as novelty or anomaly detectors to detect imminent motor failures. The autoassociator is trained to reconstruct spectra obtained from the healthy motor. In laboratory tests, we have demonstrated that the trained autoassociator has a small reconstruction error on measurements recorded from healthy motors but a larger error on those recorded from a motor with a fault. We have designed and built a motor monitoring system using an autoassociator for anomaly detection and are in the process of testing the system at three industrial and commercial sites.

There are two neural network algorithms at its cme: the first network is trained to find individual characters in an alphamuneric field, while the second one perfmns the classification. Both networks were trained on Gabor projections of the ociginal pixel images, which resulted in higher recognition rates and greater noise immunity. Compared to its purely numeric counterpart (Shusurovich and Thrasher, 1995), this version of the system has a significant applicatim specific postprocessing module. The system has been implemented in specialized parallel hardware, which allows it to run at 80 char/sec/board. It has been installed at the Driver and Vehicle Licensing Agency (DVLA) in the United Kingdom.

For example, it is trivial to record hours of heartbeats from hundreds of patients. However, it is expensive to hire cardiologists to label each of the recorded beats. One response to the expense of class labels is to squeeze the most information possible out of each labeled example. Regularization and cross-validation both have this goal. A second response is to start with a small set of labeled examples and request labels of only those currently unlabeled examples that are expected to provide a significant improvement in the behavior of the classifier (Lewis & Catlett, 1994; Freund et al., 1993). A third response is to tap into a largely ignored potential source of information; namely, unlabeled examples. This response is supported by the theoretical work of Castelli and Cover (1995) which suggests that unlabeled examples have value in learning classification problems.

Our research works towards this broad goal from a Machine Learning perspective. We are particularly interested in investigating how an intelligent agent can choose an action in an adversarial environment. We assume that the agent has a specific goal to achieve. We conduct this investigation in a framework where teams of agents compete in a game of robotic soccer. The real system of model cars remotely controlled from off-board computers is under development.

The existence of significant delays in sensorimotor feedback pathways has led several researchers to suggest that the cerebellum might function as a forward model of the motor plant in order to predict the sensory consequences of motor commands before actual feedback is available; e.g., (Ito, 1984; Keeler, 1990; Miall et ai., 1993). While we agree that there are many potential roles for forward models in motor control systems, as discussed, e.g., in (Wolpert et al., 1995), we present a hypothesis about how the cerebellum could participate in regulating movement in the presence of significant feedback delays without resorting to a forward model. We show how a very simplified version of the adjustable pattern generator (APG) model being developed by Houk and colleagues (Berthier et al., 1993; Houk et al., 1995) can learn to control endpoint positioning of a nonlinear spring-mass system with significant delays in both afferent and efferent pathways. Although much simpler than a multilink dynamic arm, control of this spring-mass system involves some of the challenges critical in the control of a more realistic motor system and serves to illustrate the principles we propose. Preliminary results appear in (Buckingham et al., 1995).

This research has been motivated by the dominance of the suboptimal symmetric phase in online learning of two-layer feedforward networks trained by gradient descent [2]. This trapping is emphasized for inappropriate small learning rates but exists in all training scenarios, effecting the learning process considerably. We Adaptive Back-Propagation in Online Learning of Multilayer Networks 329 proposed an adaptive back-propagation training algorithm [Eq.

In recent years, the interest of investors has shifted to computerized asset allocation (portfolio management) to exploit the growing dynamics of the capital markets. In this paper, asset allocation is formalized as a Markovian Decision Problem which can be optimized by applying dynamic programming or reinforcement learning based algorithms. Using an artificial exchange rate, the asset allocation strategy optimized with reinforcement learning (Q-Learning) is shown to be equivalent to a policy computed by dynamic programming. The approach is then tested on the task to invest liquid capital in the German stock market. Here, neural networks are used as value function approximators. The resulting asset allocation strategy is superior to a heuristic benchmark policy. This is a further example which demonstrates the applicability of neural network based reinforcement learning to a problem setting with a high dimensional state space.