Signal processing and classification algorithms often have limited applicability resulting from an inaccurate model of the signal's underlying structure.We present here an efficient, Bayesian algorithm for modeling a signal composed of the superposition of brief, Poisson-distributed functions. This methodology is applied to the specific problem of modeling and classifying extracellular neural waveforms which are composed of a superposition of an unknown number of action potentials CAPs). Previous approaches have had limited success due largely to the problems of determining the spike shapes, deciding how many are shapes distinct, and decomposing overlapping APs. A Bayesian solution to each of these problems is obtained by inferring a probabilistic model of the waveform. This approach quantifies the uncertainty of the form and number of the inferred AP shapes and is used to obtain an efficient method for decomposing complex overlaps. This algorithm can extract many times more information than previous methods and facilitates the extracellular investigation of neuronal classes and of interactions within neuronal circuits.

Mozer, 1991; Bharucha, 1992), the models rarely explain the way in which musical representations are constructed and learned.

Although the visual and auditory systems share the same basic tasks of informing an organism about its environment, most connectionist workon hearing to date has been devoted to the very different problem of speech recognition. VVe believe that the most fundamental task of the auditory system is the analysis of acoustic signals into components corresponding to individual sound sources, which Bregman has called auditory scene analysis. Computational and connectionist work on auditory scene analysis is reviewed, and the outline of a general model that includes these approaches is described.

We apply HMMs to the problem of modeling exons, intronsand detecting splice sites in the human genome. Our most interesting result so far is the detection of particular oscillatory patterns,with a minimal period ofroughly 10 nucleotides, that seem to be characteristic of exon regions and may have significant biological implications.

Biological neurons have a variety of intrinsic properties because of the large number of voltage dependent currents that control their activity. Neuromodulatory substances modify both the balance of conductances that determine intrinsic properties and the strength of synapses. These mechanisms alter circuit dynamics, and suggest that functional circuits exist only in the modulatory environment in which they operate. 1 INTRODUCTION Many studies of artificial neural networks employ model neurons and synapses that are considerably simpler than their biological counterparts.

Alan Lapedes Complex Systems Group (TI3) LANL, MS B213 Los Alamos N.M. 87545 and The Santa Fe Institute, Santa Fe, New Mexico Evan Steeg Department of Computer Science University of Toronto, Toronto, Canada Robert Farber Complex Systems Group (TI3) LANL, MS B213 Los Alamos N.M. 87545 Abstract We use two co-evolving neural networks to determine new classes of protein secondary structure which are significantly more predictable fromlocal amino sequence than the conventional secondary structure classification. Accurate prediction of the conventional secondary structure classes: alpha helix, beta strand, and coil, from primary sequence has long been an important problem in computational molecularbiology. Neural networks have been a popular method to attempt to predict these conventional secondary structure classes.Accuracy has been disappointingly low. The algorithm presentedhere uses neural networks to similtaneously examine both sequence and structure data, and to evolve new classes of secondary structure that can be predicted from sequence with significantly higher accuracy than the conventional classes. These new classes have both similarities to, and differences with the conventional alphahelix, beta strand and coil.

The fundamental backpropagation (BP) algorithm for training artificial neuralnetworks is cast as a deterministic nonmonotone perturbed gradientmethod. Under certain natural assumptions, such as the series of learning rates diverging while the series of their squares converging, it is established that every accumulation point of the online BP iterates is a stationary point of the BP error function. Theresults presented cover serial and parallel online BP, modified BP with a momentum term, and BP with weight decay. 1 INTRODUCTION

A fast event-driven software simulator has been developed for simulating largenetworks of spiking neurons and synapses. The primitive network elements are designed to exhibit biologically realistic behaviors, such as spiking, refractoriness, adaptation, axonal delays, summation of post-synaptic current pulses, and tonic current inputs.The efficient event-driven representation allows large networks to be simulated in a fraction of the time that would be required for a full compartmental-model simulation. Corresponding analogCMOS VLSI circuit primitives have been designed and characterized, so that large-scale circuits may be simulated prior to fabrication. 1 Introduction Artificial neural networks typically use an abstraction of real neuron behaviour, in which the continuously varying mean firing rate of the neuron is presumed to carry the information about the neuron's time-varying state of excitation [1]. This useful simplification allows the neuron's state to be represented as a time-varying continuous-amplitude quantity. However, spike timing is known to be important in many biological systems.

In an effort to understand saccadic eye movements and their relation tovisual attention and other forms of eye movements, we - in collaboration with a number of other laboratories - are carrying outa large-scale effort to design and build a complete primate oculomotor system using analog CMOS VLSI technology. Using this technology, a low power, compact, multi-chip system has been built which works in real-time using real-world visual inputs. We describe in this paper the performance of an early version of such a system including a 1-D array of photoreceptors mimicking the retina, a circuit computing the mean location of activity representing thesuperior colliculus, a saccadic burst generator, and a one degree-of-freedom rotational platform which models the dynamic properties of the primate oculomotor plant. 1 Introduction When we look around our environment, we move our eyes to center and stabilize objects of interest onto our fovea. In order to achieve this, our eyes move in quick jumps with short pauses in between. These quick jumps (up to 750 deg/sec in humans) areknown as saccades and are seen in both exploratory eye movements and as reflexive eye movements in response to sudden visual, auditory, or somatosensory stimuli.Since the intent of the saccade is to bring new objects of interest onto the fovea, it can be considered a primitive attentional mechanism.

In recent years, NIPS has heard neural networks generate tunes and harmonize chorales. With a large amount of music becoming available in computer readable form, real data can be used to train connectionist models. At the beginning of this workshop, Andreas Weigend focused on architectures to capture structure on multiple time scales.