In the mammalian visual cortex, orientation-selective'simple cells' which detect straight lines may be adapted to detect curved lines instead. We test a biologically plausible, Hebbian, single-neuron model, which learns oriented receptive fields upon exposure to unstructured (noise) input and maintains orientation selectivity upon exposure to edges or bars of all orientations and positions. This model can also learn arc-shaped receptive fields upon exposure to an environment of only circular rings. Thus, new experiments which try to induce an abnormal (curved) receptive field may provide insight into the plasticity of simple cells. The model suggests that exposing cells to only a single spatial frequency may induce more striking spatial frequency and orientation dependent effects than heretofore observed.

We present a model of catecholamine effects in a network of neural-like elements. We argue that changes in the responsivity of individual elements do not affect their ability to detect a signal and ignore noise. However. the same changes in cell responsivity in a network of such elements do improve the signal detection performance of the network as a whole. We show how this result can be used in a computer simulation of behavior to account for the effect of eNS stimulants on the signal detection performance of human subjects.

It has been known for many years that specific regions of the working cerebral cortex display periodic variations in correlated cellular activity. While the olfactory system has been the focus of much of this work, similar behavior has recently been observed in primary visual cortex. We have developed models of both the olfactory and visual cortex which replicate the observed oscillatory properties of these networks. Using these models we have examined the dependence of oscillatory behavior on single cell properties and network architectures. We discuss the idea that the oscillatory events recorded from cerebral cortex may be intrinsic to the architecture of cerebral cortex as a whole, and that these rhythmic patterns may be important in coordinating neuronal activity during sensory processmg.

The firing patterns of populations of cells in the cat visual cortex can exhibit oscillatory responses in the range of 35 - 85 Hz. Furthermore, groups of neurons many mm's apart can be highly synchronized as long as the cells have similar orientation tuning. We investigate two basic network architectures that incorporate either nearest-neighbor or global feedback interactions and conclude that non-local feedback plays a fundamental role in the initial synchronization and dynamic stability of the oscillations.

A generic model of oscillating cortex, which assumes "minimal" sociative coupling justified by known anatomy, is shown to function as an as memory, using previously developed theory. The network has explicit excitatory neurons with local inhibitory interneuron feedback that forms a set of nonlinear oscillators coupled only by long range excitatofy connections. Using a local Hebb-like learning rule for primary and higher order synapses at the ends of the long range connections, the system learns to store the kinds of oscillation amplitude patterns observed in olfactory and visual cortex. This rule is derived from a more general "projection algorithm" for recurrent analog networks, that analytically guarantees content addressable memory storage of continuous periodic sequences - capacity: N /2 Fourier components for an N node network - no "spurious" attractors. 1 Introduction This is a sketch of recent results stemming from work which is discussed completely in [1, 2, 3]. Patterns of 40 to 80 hz oscillation have been observed in the large scale activity of olfactory cortex [4] and visual neocortex [5], and shown to predict the olfactory and visual pattern recognition responses of a trained animal. It thus appears that cortical computation in general may occur by dynamical interaction of resonant modes, as has been thought to be the case in the olfactory system.

It is well-known that neural responses in particular brain regions are spatially organized, but no general principles have been developed that relate the structure of a brain map to the nature of the associated computation. On parallel computers, maps of a sort quite similar to brain maps arise when a computation is distributed across multiple processors. In this paper we will discuss the relationship between maps and computations on these computers and suggest how similar considerations might also apply to maps in the brain. 1 INTRODUCTION A great deal of effort in experimental and theoretical neuroscience is devoted to recording and interpreting spatial patterns of neural activity. A variety of map patterns have been observed in different brain regions and, presumably, these patterns reflect something about the nature of the neural computations being carried out in these regions. To date, however, there have been no general principles for interpreting the structure of a brain map in terms of properties of the associated computation.

The brain represents the skin surface as a topographic map in the somatosensory cortex. This map has been shown experimentally to be modifiable in a use-dependent fashion throughout life. We present a neural network simulation of the competitive dynamics underlying this cortical plasticity by detailed analysis of receptive field properties of model neurons during simulations of skin coactivation, cortical lesion, digit amputation and nerve section. 1 INTRODUCTION Plasticity of adult somatosensory cortical maps has been demonstrated experimentally in a variety of maps and species (Kass, et al., 1983; Wall, 1988). This report focuses on modelling primary somatosensory cortical plasticity in the adult monkey. We model the long-term consequences of four specific experiments, taken in pairs. With the first pair, behaviorally controlled stimulation of restricted skin surfaces (Jenkins, et al., 1990) and induced cortical lesions (Jenkins and Merzenich, 1987), we demonstrate that Hebbian-type dynamics is sufficient to account for the inverse relationship between cortical magnification (area of cortical map representing a unit area of skin) and receptive field size (skin surface which when stimulated excites a cortical unit) (Sur, et al., 1980; Grajski and Merzenich, 1990). These results are obtained with several variations of the basic model. We conclude that relying solely on cortical magnification and receptive field size will not disambiguate the contributions of each of the myriad circuits known to occur in the brain. With the second pair, digit amputation (Merzenich, et al., 1984) and peripheral nerve cut (without regeneration) (Merzenich, ct al., 1983), we explore the role of local excitatory connections in the model Neural Network Simulation of Somatosensory Representational Plasticity S3

Most complex behaviors appear to be governed by internal motivational states or drives that modify an animal's responses to its environment. It is therefore of considerable interest to understand the neural basis of these motivational states. Drawing upon work on the neural basis of feeding in the marine mollusc Aplysia, we have developed a heterogeneous artificial neural network for controlling the feeding behavior of a simulated insect. We demonstrate that feeding in this artificial insect shares many characteristics with the motivated behavior of natural animals. 1 INTRODUCTION While an animal's external environment certainly plays an extremely important role in shaping its actions, the behavior of even simpler animals is by no means solely reactive. The response of an animal to food, for example, cannot be explained only in terms of the physical stimuli involved. On two different occasions, the very same animal may behave in completely different ways when presented with seemingly identical pieces of food (e.g.

Traditional methods of studying neural coding characterize the encoding of known stimuli in average neural responses. Organisms face nearly the opposite task - decoding short segments of a spike train to extract information about an unknown, time-varying stimulus. Here we present strategies for characterizing the neural code from the point of view of the organism, culminating in algorithms for real-time stimulus reconstruction based on a single sample of the spike train. These methods are applied to the design and analysis of experiments on an identified movement-sensitive neuron in the fly visual system. As far as we know this is the first instance in which a direct "reading" of the neural code has been accomplished.

Neu.·al Network Analysis of Distributed Representations of Dynamical Sensory-Motor rrransformations in the Leech Shawn R. LockerYt Van Fangt and Terrence J. Sejnowski Computational Neurobiology Laboratory Salk Institute for Biological Studies Box 85800, San Diego, CA 92138 ABSTRACT Interneurons in leech ganglia receive multiple sensory inputs and make synaptic contacts with many motor neurons. These "hidden" units coordinate several different behaviors. We used physiological and anatomical constraints to construct a model of the local bending reflex. Dynamical networks were trained on experimentally derived input-output patterns using recurrent back-propagation. Units in the model were modified to include electrical synapses and multiple synaptic time constants.