Dopamine exerts two classes of effect on the sustained neural activity in prefrontal cortex that underlies working memory. Direct release in the cortex increases the contrast of prefrontal neurons, enhancing the robustness of storage. Release of dopamine in the striatum is associated with salient stimuli and makes medium spiny neurons bistable; this modulation of the output of spiny neurons affects prefrontal cortex so as to indirectly gate access to working memory and additionally damp sensitivity to noise. Existing models have treated dopamine in one or other structure, or have addressed basal ganglia gating of working memory exclusive of dopamine effects. In this paper we combine these mechanisms and explore their joint effect. We model a memory-guided saccade task to illustrate how dopamine's actions lead to working memory that is selective for salient input and has increased robustness to distraction.

Biochemical signal-transduction networks are the biological information-processing systems by which individual cells, from neurons to amoebae, perceive and respond to their chemical environments. We introduce a simplified model of a single biochemical relay and analyse its capacity as a communications channel. A diffusible ligand is released by a sending cell and received by binding to a transmembrane receptor protein on a receiving cell. This receptor-ligand interaction creates a nonlinear communications channel with non-Gaussian noise. We model this channel numerically and study its response to input signals of different frequencies in order to estimate its channel capacity. Stochastic effects introduced in both the diffusion process and the receptor-ligand interaction give the channel low-pass characteristics. We estimate the channel capacity using a water-filling formula adapted from the additive white-noise Gaussian channel.

A balanced network leads to contradictory constraints on memory models, as exemplified in previous work on accommodation of synfire chains. Here we show that these constraints can be overcome by introducing a'shadow' inhibitory pattern for each excitatory pattern of the model. This is interpreted as a doublebalance principle, whereby there exists both global balance between average excitatory and inhibitory currents and local balance between the currents carrying coherent activity at any given time frame. This principle can be applied to networks with Hebbian cell assemblies, leading to a high capacity of the associative memory. The number of possible patterns is limited by a combinatorial constraint that turns out to be P 0.06N within the specific model that we employ. This limit is reached by the Hebbian cell assembly network. To the best of our knowledge this is the first time that such high memory capacities are demonstrated in the asynchronous state of models of spiking neurons.

We present a unified view for online classification, regression, and uniclass problems. This view leads to a single algorithmic framework for the three problems. We prove worst case loss bounds for various algorithms for both the realizable case and the non-realizable case. A conversion of our main online algorithm to the setting of batch learning is also discussed. The end result is new algorithms and accompanying loss bounds for the hinge-loss.

Gradient-following learning methods can encounter problems of implementation in many applications, and stochastic variants are frequently used to overcome these difficulties. We derive quantitative learning curves for three online training methods used with a linear perceptron: direct gradient descent, node perturbation, and weight perturbation. The maximum learning rate for the stochastic methods scales inversely with the first power of the dimensionality of the noise injected into the system; with sufficiently small learning rate, all three methods give identical learning curves. These results suggest guidelines for when these stochastic methods will be limited in their utility, and considerations for architectures in which they will be effective.

The classifiers are based on dyadic classification trees (DCTs), which involve adaptively pruned partitions of the feature space. A key aspect of DCTs is their spatial adaptivity, which enables local (rather than global) fitting of the decision boundary. Our risk analysis involves a spatial decomposition of the usual concentration inequalities, leading to a spatially adaptive, data-dependent pruning criterion. For any distribution on (X, Y) whose Bayes decision boundary behaves locally like a Lipschitz smooth function, we show that the DCT error converges to the Bayes error at a rate within a logarithmic factor of the minimax optimal rate.

We consider an online learning scenario in which the learner can make predictions on the basis of a fixed set of experts. We derive upper and lower relative loss bounds for a class of universal learning algorithms involving a switching dynamics over the choice of the experts. On the basis of the performance bounds we provide the optimal a priori discretization for learning the parameter that governs the switching dynamics. We demonstrate the new algorithm in the context of wireless networks.

We demonstrate improvements over a previous chip by moving toward a significantly more versatile device. This includes a larger number of silicon neurons, more sophisticated neurons including voltage dependent charging and relative and absolute refractory periods, and enhanced programmability of neural networks. This chip builds on the basic results achieved on a previous chip and expands its versatility to get closer to a self-contained locomotion controller for walking robots. 1 Introduction Legged locomotion is a system level behavior that engages most senses and activates most muscles in the human body. Understanding of biological systems is exceedingly difficult and usually defies any unifying analysis. Walking behavior is no exception. Theories of walking are likely incomplete, often in ways that are invisible to the scientist studying these behavior in animal or human systems. Biological systems often fill in gaps and details. One way of exposing our incomplete understanding is through the process of synthesis. In this paper we report on continued progress in building the basic elements of a motor pattern generator sufficient to control a legged robot.

We present test results from spike-timing correlation learning experiments carried out with silicon neurons with STDP (Spike Timing Dependent Plasticity) synapses. The weight change scheme of the STDP synapses can be set to either weight-independent or weight-dependent mode. We present results that characterise the learning window implemented for both modes of operation. When presented with spike trains with different types of synchronisation the neurons develop bimodal weight distributions. We also show that a 2-layered network of silicon spiking neurons with STDP synapses can perform hierarchical synchrony detection.

We describe a neuromorphic chip that utilizes transistor heterogeneity, introduced by the fabrication process, to generate orientation maps similar to those imaged in vivo. Our model consists of a recurrent network of excitatory and inhibitory cells in parallel with a push-pull stage. Similar to a previous model the recurrent network displays hotspots of activity that give rise to visual feature maps. Unlike previous work, however, the map for orientation does not depend on the sign of contrast.