Natural Immune system plays a vital role in the survival of the all living being. It provides a mechanism to defend itself from external predates making it consistent systems, capable of adapting itself for survival incase of changes. The human immune system has motivated scientists and engineers for finding powerful information processing algorithms that has solved complex engineering tasks. This paper explores one of the various possibilities for solving problem in a Multiagent scenario wherein multiple robots are deployed to achieve a goal collectively. The final goal is dependent on the performance of individual robot and its survival without having to lose its energy beyond a predetermined threshold value by deploying an evolutionary computational technique otherwise called the artificial immune system that imitates the biological immune system.

We study statistical detection of grayscale objects in noisy images. The object of interest is of unknown shape and has an unknown intensity, that can be varying over the object and can be negative. No boundary shape constraints are imposed on the object, only a weak bulk condition for the object's interior is required. We propose an algorithm that can be used to detect grayscale objects of unknown shapes in the presence of nonparametric noise of unknown level. Our algorithm is based on a nonparametric multiple testing procedure. We establish the limit of applicability of our method via an explicit, closed-form, non-asymptotic and nonparametric consistency bound. This bound is valid for a wide class of nonparametric noise distributions. We achieve this by proving an uncertainty principle for percolation on finite lattices.

We present a case study of artificial intelligence techniques applied to the control of production printing equipment. Like many other real-world applications, this complex domain requires high-speed autonomous decision-making and robust continual operation. To our knowledge, this work represents the first successful industrial application of embedded domain-independent temporal planning. Our system handles execution failures and multi-objective preferences. At its heart is an on-line algorithm that combines techniques from state-space planning and partial-order scheduling. We suggest that this general architecture may prove useful in other applications as more intelligent systems operate in continual, on-line settings. Our system has been used to drive several commercial prototypes and has enabled a new product architecture for our industrial partner. When compared with state-of-the-art off-line planners, our system is hundreds of times faster and often finds better plans. Our experience demonstrates that domain-independent AI planning based on heuristic search can flexibly handle time, resources, replanning, and multiple objectives in a high-speed practical application without requiring hand-coded control knowledge.

Hierarchical clustering based on pairwise similarities is a common tool used in a broad range of scientific applications. However, in many problems it may be expensive to obtain or compute similarities between the items to be clustered. This paper investigates the hierarchical clustering of N items based on a small subset of pairwise similarities, significantly less than the complete set of N(N-1)/2 similarities. First, we show that if the intracluster similarities exceed intercluster similarities, then it is possible to correctly determine the hierarchical clustering from as few as 3N log N similarities. We demonstrate this order of magnitude savings in the number of pairwise similarities necessitates sequentially selecting which similarities to obtain in an adaptive fashion, rather than picking them at random. We then propose an active clustering method that is robust to a limited fraction of anomalous similarities, and show how even in the presence of these noisy similarity values we can resolve the hierarchical clustering using only O(N log^2 N) pairwise similarities.

A computational challenge to validate the candidate disease genes identified in a high-throughput genomic study is to elucidate the associations between the set of candidate genes and disease phenotypes. The conventional gene set enrichment analysis often fails to reveal associations between disease phenotypes and the gene sets with a short list of poorly annotated genes, because the existing annotations of disease causative genes are incomplete. We propose a network-based computational approach called rcNet to discover the associations between gene sets and disease phenotypes. Assuming coherent associations between the genes ranked by their relevance to the query gene set, and the disease phenotypes ranked by their relevance to the hidden target disease phenotypes of the query gene set, we formulate a learning framework maximizing the rank coherence with respect to the known disease phenotype-gene associations. An efficient algorithm coupling ridge regression with label propagation, and two variants are introduced to find the optimal solution of the framework. We evaluated the rcNet algorithms and existing baseline methods with both leave-one-out cross-validation and a task of predicting recently discovered disease-gene associations in OMIM. The experiments demonstrated that the rcNet algorithms achieved the best overall rankings compared to the baselines. To further validate the reproducibility of the performance, we applied the algorithms to identify the target diseases of novel candidate disease genes obtained from recent studies of GWAS, DNA copy number variation analysis, and gene expression profiling. The algorithms ranked the target disease of the candidate genes at the top of the rank list in many cases across all the three case studies. The rcNet algorithms are available as a webtool for disease and gene set association analysis at http://compbio.cs.umn.edu/dgsa_rcNet.

Privacy-preserving machine learning algorithms are crucial for the increasingly common setting in which personal data, such as medical or financial records, are analyzed. We provide general techniques to produce privacy-preserving approximations of classifiers learned via (regularized) empirical risk minimization (ERM). These algorithms are private under the $\epsilon$-differential privacy definition due to Dwork et al. (2006). First we apply the output perturbation ideas of Dwork et al. (2006), to ERM classification. Then we propose a new method, objective perturbation, for privacy-preserving machine learning algorithm design. This method entails perturbing the objective function before optimizing over classifiers. If the loss and regularizer satisfy certain convexity and differentiability criteria, we prove theoretical results showing that our algorithms preserve privacy, and provide generalization bounds for linear and nonlinear kernels. We further present a privacy-preserving technique for tuning the parameters in general machine learning algorithms, thereby providing end-to-end privacy guarantees for the training process. We apply these results to produce privacy-preserving analogues of regularized logistic regression and support vector machines. We obtain encouraging results from evaluating their performance on real demographic and benchmark data sets. Our results show that both theoretically and empirically, objective perturbation is superior to the previous state-of-the-art, output perturbation, in managing the inherent tradeoff between privacy and learning performance.

Inspired by biological vision systems, the over-complete local features with huge cardinality are increasingly used for face recognition during the last decades. Accordingly, feature selection has become more and more important and plays a critical role for face data description and recognition. In this paper, we propose a trainable feature selection algorithm based on the regularized frame for face recognition. By enforcing a sparsity penalty term on the minimum squared error (MSE) criterion, we cast the feature selection problem into a combinatorial sparse approximation problem, which can be solved by greedy methods or convex relaxation methods. Moreover, based on the same frame, we propose a sparse Ho-Kashyap (HK) procedure to obtain simultaneously the optimal sparse solution and the corresponding margin vector of the MSE criterion. The proposed methods are used for selecting the most informative Gabor features of face images for recognition and the experimental results on benchmark face databases demonstrate the effectiveness of the proposed methods.

This study is focused on the development of the cortex-like visual object recognition system. We propose a general framework, which consists of three hierarchical levels (modules). These modules functionally correspond to the V1, V4 and IT areas. Both bottom-up and top-down connections between the hierarchical levels V4 and IT are employed. The higher the degree of matching between the input and the preferred stimulus, the shorter the response time of the neuron. Therefore information about a single stimulus is distributed in time and is transmitted by the waves of spikes. The reciprocal connections and waves of spikes implement predictive coding: an initial hypothesis is generated on the basis of information delivered by the first wave of spikes and is tested with the information carried by the consecutive waves. The development is considered as extraction and accumulation of features in V4 and objects in IT. Once stored a feature can be disposed, if rarely activated. This cause update of feature repository. Consequently, objects in IT are also updated. This illustrates the growing process and dynamical change of topological structures of V4, IT and connections between these areas.

We present a novel variant of decision making based on the mathematical theory of separable Hilbert spaces. This mathematical structure captures the effect of superposition of composite prospects, including many incorporated intentions, which allows us to describe a variety of interesting fallacies and anomalies that have been reported to particularize the decision making of real human beings. The theory characterizes entangled decision making, non-commutativity of subsequent decisions, and intention interference. We demonstrate how the violation of the Savage's sure-thing principle, known as the disjunction effect, can be explained quantitatively as a result of the interference of intentions, when making decisions under uncertainty. The disjunction effects, observed in experiments, are accurately predicted using a theorem on interference alternation that we derive, which connects aversion-to-uncertainty to the appearance of negative interference terms suppressing the probability of actions. The conjunction fallacy is also explained by the presence of the interference terms. A series of experiments are analysed and shown to be in excellent agreement with a priori evaluation of interference effects. The conjunction fallacy is also shown to be a sufficient condition for the disjunction effect and novel experiments testing the combined interplay between the two effects are suggested.

Under what conditions is an edge present in a social network at time t likely to decay or persist by some future time t + Delta(t)? Previous research addressing this issue suggests that the network range of the people involved in the edge, the extent to which the edge is embedded in a surrounding structure, and the age of the edge all play a role in edge decay. This paper uses weighted data from a large-scale social network built from cell-phone calls in an 8-week period to determine the importance of edge weight for the decay/persistence process. In particular, we study the relative predictive power of directed weight, embeddedness, newness, and range (measured as outdegree) with respect to edge decay and assess the effectiveness with which a simple decision tree and logistic regression classifier can accurately predict whether an edge that was active in one time period continues to be so in a future time period. We find that directed edge weight, weighted reciprocity and time-dependent measures of edge longevity are highly predictive of whether we classify an edge as persistent or decayed, relative to the other types of factors at the dyad and neighborhood level.