The prescriptions were placed in rat dom Materials and Methods CASE 6.--A 42-year-old woman had a order and in a standardized format to Ten patients with infectious meningitis three-day history of headache, nausea, and disguise the identities of the individual were selected by a physician who was not fever.

CONGEN: the constrained generation of chemical structures.

PUFF is now in routine use in Presbyterian Hospital, Pacific Medical Center (PMC), in San Francisco. The program produces a report, intended for patient records, that explains the clinical significance of measured quantitative test results and gives a diagnosis of the presence and severity of pulmonary disease in terms of the measured data, referral diagnosis, and patient history. "Rules", or statements of the form "IF condition THEN conclusion ", are used by the physiologist and the computer system to specify the system operation. The sequence of rules used to interpret the case also specifies a line of reasoning about the case, or the detailed explanation of the interpretation of the case. The use of rules for this type of knowledge based system is taken from the results of applied Artificial Intelligence research. In a 144 case prospective evaluation, there was a 91% overall rate of agreement between the rule based system diagnoses and the diagnoses of the designing physiologist; there was a 89% rate of agreement between the system diagnoses and diagnoses of a second independent physiologist.

References 67 October 27, 1977 1 Introduction This application addresses the continuation of research on the applications of artificial intelligence (Al) (1) to experimental molecular genetics. It is an extension of a longstanding effort to cultivate attention to ongoing laboratory research as a domain of explorations in artificial intelligence. Our major effort in this field had been in the DENDRNL project, with analytical organic chemistry as the object discipline.

The performance of a computer-based clinical consultation system is evaluated. The program, called MYCIN, is designed to function as an aid for infectious disease diagnosis are therapy selection, with an initial emphasis on bacteremias. The evaluation methodology is discussed, as well as the difficulties encountered in attempting to evaluate clinical judgments. Specialists in infectious diseases judged MYCIN's final therapy recommendation, and intermediate conclusions about the significance of the infection and identity of infecting organisms. The evaluation techniques described may be useful in assessing the performance of other clinical decision aids. Results of the evaluation show that the program's therapy recommendations meet Stanford experts' standards of acceptable practice 90.9% of the time (Table II), with some variation noted both among individual experts and between Stanford experts and others (Tables I and II).

In collaboration with other members of the MOLGEN project, the author developed a representation system called the "Unit Package" which became operational in July 1977. In some cases (and usually in ignorance), this work has duplicated other representation work that was happening at about the same time. The Unit Package is now being used by several other projects including two away from Stanford. It is written in INTERLISP and runs under the TENEX and TOPS20 operating systems. It is an interactive system for building knowledge-based programs. It also provides a substantial virtual memory so that knowledge bases of several thousand nodes can created without sacrificing the IlTrERLISP environment.

This is traditionally done with tne aid of a computer programmer acting as intermediary. The dire_t transfer of knowledge from an expert to the system requires a natural-language processor capable of handling a substantial subset of English. The development of such a natural-language processor is a long-term goal of automating knowledge acquisition; faciliting the interface between the expert and the system is a first step toward this goal. This paper describes BAUBAb, a program designed and implemented for hYCIN (Shortliffe 1974), a medical consultation system for infectious disease diagnosis and therapy selection. EAUdAb is concerned with the problem of parsing - recognizing natural language sentences aad encoding tnem into MICIN's internal representation. For this purpose, it uses a semantic grammar in whicft tne non-terminal symools denote semantic categories (e.g., infections and symptoms), or conceptual categories wnicn are common tools of knowledge representation in artificial intelligence (e.g.

For This paper and the following one' describe the current effort most applications the familiar geometric point group is chosen to provide the CONG EN (for constrained structure generation) .22 In some spectroscopic applications It is necessary to take program with stereochemical capabilities.* This paper is primarily internal motion into account and specify a nonrigid symmetry concerned with the chemical and mathematical theory group.2b For applications in dynamic stereochemistry it is necessary to this effort. The following paper is concerned primarily necessary to consider the group of all permutations of identical with novel algorithms and the computer implementation.7 atoms and often several subgroups.3 Symmetry groups that A third paper considers the theory in greater mathematical include the point group and operations that invert chiral centers detail with some extensions to other topics.' are useful both in constructing chirality functions4 and in specifying the pseudochirality of a structure.5

We view this process as occurring in several stages, which together form a data hierarchy (Figure 3.1). The hierarchy offers an overview of DSS function and suggests a task partitioning suitable for a contract net approach.

The discussion centers on a specific video terminal designed and constructed by the authors. This terminal is based on the Intel 8080 microprocessor and is equipped with software sufficient to emiflate the characteristics of standard video terminals required by eral available screen -oriented text editors in common use at sites throughout the ARPAnet (such as E [Samuel, 1978] and TV-Edit [kanerva, 1975]). Screen-oriented editors2 differ from other editors In their use of high-speed video terminals to display the contents of large sections of a file being edited. As editing operations are performed, the display Is revised to indicate their effects on the file (i.e., editing operates In a What you see is what you get mode). Such editors require ter.linals capable of primitive text-processing operations, such as inserting a character in a line of text by shifting the existing characters. In addition to such capabilities, the terminal is typically expected to support 8-bit transmission (instead of the usual 7 bits plus parity), selectable modes for displaying characters (e.g., normal or inverse video, blinking, or dual intensity), and an 80-character line width.