In this paper we present a sequential investment strategy - a portfolio selection strategy or portfolio optimization technique - that could be used in financial markets. Sequential investment means that at the end of one trading period the investor is allowed to redistribute his current capital among a set of available assets. The investor's goal is to maximize his capital. The portfolio selection is based on historical data collected from the market. Local linear regression base models or experts are used in an ensemble called a committee to model the nextday return of an asset. The committees use different voting strategies to provide the estimate for each asset. The estimates along with historical performances will be used to generate portfolio weights for a given trading period. Numerical results will be presented to show the performance of the portfolio selection strategy.

The linking genotype to phenotype is the fundamental aim of modern genetics. We focus on study of links between gene expression data and phenotype data through integrative analysis. We propose three approaches. 1) The inherent complexity of phenotypes makes high-throughput phenotype profiling a very difficult and laborious process. We propose a method of automated multi-dimensional profiling which uses gene expression similarity. Large-scale analysis show that our method can provide robust profiling that reveals different phenotypic aspects of samples. This profiling technique is also capable of interpolation and extrapolation beyond the phenotype information given in training data. It can be used in many applications, including facilitating experimental design and detecting confounding factors. 2) Phenotype association analysis problems are complicated by small sample size and high dimensionality. Consequently, phenotype-associated gene subsets obtained from training data are very sensitive to selection of training samples, and the constructed sample phenotype classifiers tend to have poor generalization properties. To eliminate these obstacles, we propose a novel approach that generates sequences of increasingly discriminative gene cluster combinations. Our experiments on both simulated and real datasets show robust and accurate classification performance. 3) Many complex phenotypes, such as cancer, are the product of not only gene expression, but also gene interaction. We propose an integrative approach to find gene network modules that activate under different phenotype conditions. Using our method, we discovered cancer subtype-specific network modules, as well as the ways in which these modules coordinate. In particular, we detected a breast-cancer specific tumor suppressor network module with a hub gene, PDGFRL, which may play an important role in this module.

Machine learning methods for solving the equations of dynamical mean-field theory are developed. The method is demonstrated on the three dimensional Hubbard model. The key technical issues are defining a mapping of an input function to an output function, and distinguishing metallic from insulating solutions. Both metallic and Mott insulator solutions can be predicted. The validity of the machine learning scheme is assessed by comparing predictions of full correlation functions, of quasi-particle weight and particle density to values directly computed. The results indicate that with modest further development, machine learning approach may be an attractive computational efficient option for real materials predictions for strongly correlated systems.

Goal: This paper deals with the problems that some EEG signals have no good sparse representation and single channel processing is not computationally efficient in compressed sensing of multi-channel EEG signals. Methods: An optimization model with L0 norm and Schatten-0 norm is proposed to enforce cosparsity and low rank structures in the reconstructed multi-channel EEG signals. Both convex relaxation and global consensus optimization with alternating direction method of multipliers are used to compute the optimization model. Results: The performance of multi-channel EEG signal reconstruction is improved in term of both accuracy and computational complexity. Conclusion: The proposed method is a better candidate than previous sparse signal recovery methods for compressed sensing of EEG signals. Significance: The proposed method enables successful compressed sensing of EEG signals even when the signals have no good sparse representation. Using compressed sensing would much reduce the power consumption of wireless EEG system.

Mixture of Experts (MoE) is a popular framework for modeling heterogeneity in data for regression, classification and clustering. For continuous data which we consider here in the context of regression and cluster analysis, MoE usually use normal experts, that is, expert components following the Gaussian distribution. However, for a set of data containing a group or groups of observations with asymmetric behavior, heavy tails or atypical observations, the use of normal experts may be unsuitable and can unduly affect the fit of the MoE model. In this paper, we introduce new non-normal mixture of experts (NNMoE) which can deal with these issues regarding possibly skewed, heavy-tailed data and with outliers. The proposed models are the skew-normal MoE and the robust $t$ MoE and skew $t$ MoE, respectively named SNMoE, TMoE and STMoE. We develop dedicated expectation-maximization (EM) and expectation conditional maximization (ECM) algorithms to estimate the parameters of the proposed models by monotonically maximizing the observed data log-likelihood. We describe how the presented models can be used in prediction and in model-based clustering of regression data. Numerical experiments carried out on simulated data show the effectiveness and the robustness of the proposed models in terms modeling non-linear regression functions as well as in model-based clustering. Then, to show their usefulness for practical applications, the proposed models are applied to the real-world data of tone perception for musical data analysis, and the one of temperature anomalies for the analysis of climate change data.

In this paper, a nonparametric maximum likelihood (ML) estimator for band-limited (BL) probability density functions (pdfs) is proposed. The BLML estimator is consistent and computationally efficient. To compute the BLML estimator, three approximate algorithms are presented: a binary quadratic programming (BQP) algorithm for medium scale problems, a Trivial algorithm for large-scale problems that yields a consistent estimate if the underlying pdf is strictly positive and BL, and a fast implementation of the Trivial algorithm that exploits the band-limited assumption and the Nyquist sampling theorem ("BLMLQuick"). All three BLML estimators outperform kernel density estimation (KDE) algorithms (adaptive and higher order KDEs) with respect to the mean integrated squared error for data generated from both BL and infinite-band pdfs. Further, the BLMLQuick estimate is remarkably faster than the KD algorithms. Finally, the BLML method is applied to estimate the conditional intensity function of a neuronal spike train (point process) recorded from a rat's entorhinal cortex grid cell, for which it outperforms state-of-the-art estimators used in neuroscience.

This work studies two interrelated problems - online robust PCA (RPCA) and online low-rank matrix completion (MC). In recent work by Cand\`{e}s et al., RPCA has been defined as a problem of separating a low-rank matrix (true data), $L:=[\ell_1, \ell_2, \dots \ell_{t}, \dots , \ell_{t_{\max}}]$ and a sparse matrix (outliers), $S:=[x_1, x_2, \dots x_{t}, \dots, x_{t_{\max}}]$ from their sum, $M:=L+S$. Our work uses this definition of RPCA. An important application where both these problems occur is in video analytics in trying to separate sparse foregrounds (e.g., moving objects) and slowly changing backgrounds. While there has been a large amount of recent work on both developing and analyzing batch RPCA and batch MC algorithms, the online problem is largely open. In this work, we develop a practical modification of our recently proposed algorithm to solve both the online RPCA and online MC problems. The main contribution of this work is that we obtain correctness results for the proposed algorithms under mild assumptions. The assumptions that we need are: (a) a good estimate of the initial subspace is available (easy to obtain using a short sequence of background-only frames in video surveillance); (b) the $\ell_t$'s obey a `slow subspace change' assumption; (c) the basis vectors for the subspace from which $\ell_t$ is generated are dense (non-sparse); (d) the support of $x_t$ changes by at least a certain amount at least every so often; and (e) algorithm parameters are appropriately set

This paper explores the use of general-purpose machine translation (MT) in assisting the users of computer-aided translation (CAT) systems based on translation memory (TM) to identify the target words in the translation proposals that need to be changed (either replaced or removed) or kept unedited, a task we term as "word-keeping recommendation". MT is used as a black box to align source and target sub-segments on the fly in the translation units (TUs) suggested to the user. Source-language (SL) and target-language (TL) segments in the matching TUs are segmented into overlapping sub-segments of variable length and machine-translated into the TL and the SL, respectively. The bilingual sub-segments obtained and the matching between the SL segment in the TU and the segment to be translated are employed to build the features that are then used by a binary classifier to determine the target words to be changed and those to be kept unedited. In this approach, MT results are never presented to the translator. Two approaches are presented in this work: one using a word-keeping recommendation system which can be trained on the TM used with the CAT system, and a more basic approach which does not require any training. Experiments are conducted by simulating the translation of texts in several language pairs with corpora belonging to different domains and using three different MT systems. We compare the performance obtained to that of previous works that have used statistical word alignment for word-keeping recommendation, and show that the MT-based approaches presented in this paper are more accurate in most scenarios. In particular, our results confirm that the MT-based approaches are better than the alignment-based approach when using models trained on out-of-domain TMs. Additional experiments were performed to check how dependent the MT-based recommender is on the language pair and MT system used for training. These experiments confirm a high degree of reusability of the recommendation models across various MT systems, but a low level of reusability across language pairs.

The modelling of data on a spherical surface requires the consideration of directional probability distributions. To model asymmetrically distributed data on a three-dimensional sphere, Kent distributions are often used. The moment estimates of the parameters are typically used in modelling tasks involving Kent distributions. However, these lack a rigorous statistical treatment. The focus of the paper is to introduce a Bayesian estimation of the parameters of the Kent distribution which has not been carried out in the literature, partly because of its complex mathematical form. We employ the Bayesian information-theoretic paradigm of Minimum Message Length (MML) to bridge this gap and derive reliable estimators. The inferred parameters are subsequently used in mixture modelling of Kent distributions. The problem of inferring the suitable number of mixture components is also addressed using the MML criterion. We demonstrate the superior performance of the derived MML-based parameter estimates against the traditional estimators. We apply the MML principle to infer mixtures of Kent distributions to model empirical data corresponding to protein conformations. We demonstrate the effectiveness of Kent models to act as improved descriptors of protein structural data as compared to commonly used von Mises-Fisher distributions.

Stochastic variational inference (SVI) is emerging as the most promising candidate for scaling inference in Bayesian probabilistic models to large datasets. However, the performance of these methods has been assessed primarily in the context of Bayesian topic models, particularly latent Dirichlet allocation (LDA). Deriving several new algorithms, and using synthetic, image and genomic datasets, we investigate whether the understanding gleaned from LDA applies in the setting of sparse latent factor models, specifically beta process factor analysis (BPFA). We demonstrate that the big picture is consistent: using Gibbs sampling within SVI to maintain certain posterior dependencies is extremely effective. However, we find that different posterior dependencies are important in BPFA relative to LDA. Particularly, approximations able to model intra-local variable dependence perform best.