Large language models (LLMs) have revolutionized natural language processing and are increasingly applied to other sequential data types, including genetic sequences. However, adapting LLMs to genetics presents significant challenges. Capturing complex genomic interactions requires modeling long-range global dependencies within DNA sequences, where interactions often span over 10,000 base pairs, even within a single gene. This poses substantial computational demands under conventional model architectures and training paradigms. Additionally, traditional LLM training approaches are suboptimal for DNA sequences: autoregressive training, while efficient for training, only supports unidirectional sequence understanding. However, DNA is inherently bidirectional.

The first ever halftime show at a FIFA World Cup final has been curated by Coldplay's Chris Martin and will feature performances from global superstars.

Nature is always performing chemistry experiments, and in the dark and sticky corners of its forests and jungles, it creates compounds that have hyper-specific effects on the human mind. Many people of different ages and cultural backgrounds have eaten this mushroom and experienced the same hallucination. They report seeing elf-like figures that parkour around on clothes, on furniture, and on walls. These little people seem to like dancing and performing acrobatics. Large groups of them will march in formation. This "lilliputian hallucination" can last for a day, and closing your eyes is no escape.

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PCWorld analyzes how Anthropic's powerful Fable 5 AI model faces accessibility issues and data retention controversies, while Apple's revamped Siri offers practical integration. Apple's AI features include iCloud data analysis, email composition, and Private Cloud Compute for privacy, making AI tools accessible to millions of users. Despite Fable 5's advanced capabilities, Apple's approach appears more likely to deliver meaningful AI benefits for everyday tasks and decision-making. Anthropic's first Mythos-class Claude model, Fable 5, hit the world like an atom bomb this week, and that's barely an exaggeration. But Apple's rebooted Siri could be the AI moment that actually reaches everyone else. A modified version of Mythos, the benchmark-shattering Claude model that's scary-good at cybersecurity and worryingly knowledgeable about bioweapons, Fable 5 comes wrapped in so many safeguards that it reportedly refuses even the most basic chats about biology .

Claire chatted to Edward Mehr from Machina Labs about their RoboCraftsman that shapes complex metal parts for the aerospace, defence, and automotive industries. Edward Mehr is an entrepreneur and engineer specializing in advanced manufacturing, robotics, and artificial intelligence. As the Co-Founder and CEO of Machina Labs, he leads efforts to integrate AI-driven robotics into flexible, on-demand production systems. Under his leadership, Machina Labs is reshaping how industries such as aerospace, defence, and automotive approach metal forming and modern manufacturing. Before founding Machina Labs, Ed worked at leading technology companies, including Relativity Space, Averon, SpaceX, Google, and Microsoft.

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Large Language Models (LLMs) offer substantial promise for clinical natural language processing (NLP); however, a lack of standardized benchmarking methodologies limits their objective evaluation and practical translation. To address this gap, we introduce ClinBench, an open-source, multi-model, multi-domain benchmarking framework. ClinBench is designed for the rigorous evaluation of LLMs on important structured information extraction tasks (e.g., tumor staging, histologic diagnoses, atrial fibrillation, and social determinants of health) from unstructured clinical notes. The framework standardizes the evaluation pipeline by: (i) operating on consistently structured input datasets; (ii) employing dynamic, YAML-based prompting for uniform task definition; and (iii) enforcing output validation via JSON schemas, supporting robust comparison across diverse LLM architectures. We demonstrate ClinBench through a large-scale study of 11 prominent LLMs (e.g., GPT-4o series, LLaMA3 variants, Mixtral) across three clinical domains using configurations of public datasets (TCGA for lung cancer, MIMIC-IV-ECG for atrial fibrillation, and MIMIC notes for SDOH). Our results reveal significant performance-efficiency trade-offs. For example, when averaged across the four benchmarked clinical extraction tasks, GPT-3.5-turbo

France-Germany jet plans crash: Can Europe end reliance on US for security? France and Germany have announced this week that they are ditching a landmark project to jointly develop a sixth-generation fighter jet. French President Emmanuel Macron confirmed on Monday that the project is being terminated, in what is being seen as a major blow to efforts to boost defence cooperation between European Union states, a key issue amid uncertainty cast by United States President Donald Trump over the readiness of the US to help defend its NATO allies. Since 2019, the US president has been flirting with the idea of obtaining Greenland . His remarks about his desire for the island, a self-governing territory which is part of the Kingdom of Denmark, built to a crescendo at the start of this year, with European leaders signalling their displeasure with the idea and Trump even threatening additional trade tariffs on those countries standing in his way.

Craig Federighi, Apple's SVP of engineering, said the new Siri will resist attempts at romance. Siri AI will fend off users' attempts at romancing it, according to Craig Federighi, Apple's SVP of engineering. As MacRumors has reported, Federighi clarified that the upgraded Siri for iOS 27 won't suck up to you like other AIs in an interview with the podcast, along with Apple marketing chief Greg Joswiak. Quite the opposite because as you may know, if you use many of the existing chat bots, they're really focused on engagement to a large degree. They kind of wanna pull you in, Federighi replied when asked about the possibility of Siri becoming a user's AI partner.